ABSTRACT: BACKGROUND: Gastrointestinal symptoms are not an uncommon manifestation of an influenza virusinfection. In the present study, we aimed to investigate the presence of influenza viruses inthe stools of adult patients consulting their general practitioner for uncomplicated acutediarrhea (AD) and the proportion of concurrent infections by enteric and influenza viruses. METHOD: A case-control study was conducted from December 2010 to April 2011. Stool specimenswere collected and tested for influenza viruses A (seasonal A/H3N2 and pandemic A/H1N1)and B, and for four enteric viruses (astrovirus, group A rotavirus, human enteric adenovirus,norovirus of genogroups I - NoVGI - and genogroup II - NoVGII). RESULTS: General practitioners enrolled 138 cases and 93 controls. Of the 138 stool specimenscollected, 92 (66.7%) were positive for at least one of the four enteric viruses analysed and 10(7.2%) tested positive for one influenza virus. None of these 10 influenza positive patientsreported respiratory symptoms. In five influenza-positive patients (3.6%), we also detectedone enteric virus, with 4 of them being positive for influenza B (2 had co-detection withNoVGI, 1 with NoVGII, and 1 with astrovirus). None of the 93 controls tested positive forone of the enteric and/or other influenza viruses we investigated. CONCLUSIONS: In this study we showed that the simultaneous detection of influenza and enteric viruses is nota rare event. We have also reported, for the first time in general practice, the presence ofseasonal and pandemic influenza viruses in the stools of adult patients consulting foruncomplicated AD. A simultaneous investigation of enteric and influenza viruses in patientscomplaining of gastrointestinal symptoms could be useful for future studies to better identifythe agents responsible for AD.