Ca2+ oscillations mediated by the synergistic excitatory actions of GABA(A) and NMDA receptors in the neonatal hippocampus. - Archive ouverte HAL Access content directly
Journal Articles Neuron Year : 1997

Ca2+ oscillations mediated by the synergistic excitatory actions of GABA(A) and NMDA receptors in the neonatal hippocampus.

Abstract

We asked whether GABA(A) and NMDA receptors may act in synergy in neonatal hippocampal slices, at a time when GABA exerts a depolarizing action. The GABA(A) receptor agonist isoguvacine reduced the voltage-dependent Mg2+ block of single NMDA channels recorded in cell-attached configuration from P(2-5) CA3 pyramidal neurons and potentiated the Ca2+ influx through NMDA channels. The synaptic response evoked by electrical stimulation of stratum radiatum was mediated by a synergistic interaction between GABA(A) and NMDA receptors. Network-driven Giant Depolarizing Potentials, which are a typical feature of the neonatal hippocampal network, provided coactivation of GABA(A) and NMDA receptors and were associated with spontaneous and synchronous Ca2+ increases in CA3 pyramidal neurons. Thus, at the early stages of development, GABA is a major excitatory transmitter that acts in synergy with NMDA receptors. This provides in neonatal neurons a hebbian stimulation that may be involved in neuronal plasticity and network formation in the developing hippocampus.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

inserm-00522468 , version 1 (30-09-2010)

Identifiers

  • HAL Id : inserm-00522468 , version 1
  • PUBMED : 9052795

Cite

Xavier Leinekugel, Igor Medina, Ilgham Khalilov, Yezekiel Ben-Ari, Roustem Khazipov. Ca2+ oscillations mediated by the synergistic excitatory actions of GABA(A) and NMDA receptors in the neonatal hippocampus.. Neuron, 1997, 18 (2), pp.243-55. ⟨inserm-00522468⟩

Collections

INSERM
63 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More