Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone. - Archive ouverte HAL Access content directly
Journal Articles Journal of Cystic Fibrosis Year : 2010

Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone.

Abstract

Bone loss is an important clinical issue in patients with cystic fibrosis (CF). Whether the cystic fibrosis transmembrane conductance regulator (CFTR) plays a direct role in bone cell function is yet unknown. In this study, we provide evidence that inhibition of CFTR-Cl(-) channel function results in a significant decrease of osteoprotegerin (OPG) secretion accompanied with a concomitant increase of prostaglandin (PG) E(2) secretion of primary human osteoblast cultures (n=5). Our data therefore suggest that in bone cells of CF patients, the loss of CFTR activity may result in an increased inflammation-driven bone resorption (through both the reduced OPG and increased PGE(2) production), and thus might contribute to the early bone loss reported in young children with CF.
Embargoed file
Embargoed file
Visibility date is undetermined

Dates and versions

inserm-00501818 , version 1 (12-07-2010)

Identifiers

Cite

Louis Le Heron, Christine Guillaume, Frédéric Velard, Julien Braux, Lhousseine Touqui, et al.. Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone.. Journal of Cystic Fibrosis, 2010, 9 (1), pp.69-72. ⟨10.1016/j.jcf.2009.11.005⟩. ⟨inserm-00501818⟩
140 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More