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            <title xml:lang="en">Synthesis of a 200-member library of squaric acid N-hydroxylamide amides.</title>
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                <forename type="first">Julie</forename>
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            <idno type="halRefHtml">&lt;i&gt;Bioorganic and Medicinal Chemistry Letters&lt;/i&gt;, 2008, 18 (18), pp.4968-71. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.bmcl.2008.08.025"&gt;&amp;#x27E8;10.1016/j.bmcl.2008.08.025&amp;#x27E9;&lt;/a&gt;</idno>
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                <title xml:lang="en">Synthesis of a 200-member library of squaric acid N-hydroxylamide amides.</title>
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                    <forename type="first">Benoît</forename>
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                    <surname>Déprez</surname>
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                    <forename type="first">Rébecca</forename>
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                <title level="j">Bioorganic and Medicinal Chemistry Letters</title>
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                  <biblScope unit="volume">18</biblScope>
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              <p>We report here the parallel synthesis of 200 compounds based on squaric acid template. These compounds are obtained via a one-step solution-phase procedure starting from three squaric acid N-hydroxylamide esters precursors. The set of diverse reagents qualified (amines, anilines, amino-alcohols and amino-esters) makes this strategy suitable for the search of biologically active compounds. The library was screened on the zinc metalloenzyme ADAMTS-5 and hits with IC(50) in the range of 1-50 microM were identified.</p>
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