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Article Dans Une Revue Alimentary Pharmacology and Therapeutics Année : 2008

Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndrome.

Résumé

BACKGROUND: Relationships between pain threshold during rectal distension and both symptoms intensity and alteration in quality of life (QoL) in irritable bowel syndrome (IBS) patients have been poorly evaluated. AIM: To evaluate relationships between rectal sensitivity, IBS symptom intensity and QoL in a multicentre prospective study. METHODS: Rectal threshold for moderate pain was measured during rectal distension in IBS patients (Rome II), while IBS symptoms intensity was assessed by a validated questionnaire and QoL by the Functional Digestive Disorder Quality of Life questionnaire. RESULTS: Sixty-eight patients (44.2 +/- 12.7 years, 48 women) were included. The mean rectal distending volume for moderate pain was 127 +/- 35 mL while 45 patients (66%) had rectal hypersensitivity (pain threshold <140 mL). Rectal threshold was not significantly related either to overall IBS intensity score (r = -0.66, P = 0.62) or to its different components, or to FDDQL score (r = 0.30, P = 0.14). Among FDDQL domains, only anxiety (r = 0.30, P = 0.01) and coping (r = 0.31, P = 0.009) were significantly related with pain threshold. CONCLUSIONS: In this study, two-thirds of IBS patients exhibited rectal hypersensitivity. No significant correlation was found between rectal threshold and either symptom intensity or alteration in QoL.
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Dates et versions

inserm-00320128 , version 1 (09-06-2009)

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Jean-Marc Sabaté, Michel Veyrac, François Mion, Laurent Siproudhis, Philippe Ducrotté, et al.. Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndrome.: rectal sensitivity, IBS severity and QoL. Alimentary Pharmacology and Therapeutics, 2008, 28 (4), pp.484-90. ⟨10.1111/j.1365-2036.2008.03759.x⟩. ⟨inserm-00320128⟩
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