Deliverable 4.1 is a report on the mapping of the European gene-based and cell therapies landscape. This deliverable provides an update to the earlier deliverable, D.4.8 Initial Landscape Mapping, which was submitted in the first reporting period. D4.8 reported the mapping, performed by EuroGCT, of the European landscapes associated with gene and cell therapy related product development pathways including ethical, legal, regulatory and societal issues (ELSI). Related, D4.7 Information collation, also submitted in the first reporting period, detailed our methodology for information collection and curation. The work reported in D4.7 and D4.8 resulted in creation of a development framework for a practical tool entitled “Development pathways for bringing gene and cell therapies from the lab to patients” with the short website name of “Research Pathways” (see D4.8). This tool was organised as a Web tree, into which general information on the development pathways for bringing gene and cell therapies from the lab to patients (hereafter the “Research Pathways Tree”) was organised. The Research Pathways Tree also included the organised information (mapping/inventory of information) of the practical steps required for cell and gene therapy development in Europe as well as links on relevant and existing information and guidance. The present report, D4.1, therefore moves beyond the initial mapping to focus on implementation of these processes. This has required a combination of actions: Identification of the detailed information required to populate the Research Pathways Tree was described in D4.8; in this reporting period, we have: 1) created original EuroGCT resources around development pathways for bringing gene and cell therapies from the lab to patients, the Research Pathways Tree (see D4.8 Annex 1 for details), 2) co-developed resources through collaboration, 3) selected and signposted to existing high quality resources (based on the methodology detailed in D4.7), and 4) launched an updated ‘Research Pathways’ database featuring improved navigability and information organisation. In the following sections, we provide the details of each action we have taken, our thought processes and some challenges we have come across. The outputs are published on the EuroGCT website in the Research Pathways section (www.eurogct.org/research-pathways) as a searchable and filterable database and will continually be updated throughout the course of the project. (See also: D4.2).