This article addresses the perspectives and limits of the ever expanding research agenda of various forms of (active or passive) resistance to EU policy change. While taking stock of existing research on Euroscepticism, social movements, Europeanisation and non-compliance, the paper seeks to go beyond their limitations and proposes a broader analytical framework. This framework shall serve to study resistance to policy change in the EU in three constitutive dimensions: its causes, its forms and its effects. We formulate four hypotheses: 1/ a “positive-negative integration hypothesis” analysing the nature of change as a motivation for agents to resist; 2/ a “disposition hypothesis” relating to the perception and framing of change; 3/ an “arena shifting hypothesis” examining the institutional possibilities for resisting at the national or EU political arena; and 4/ a twofold “concentration hypothesis” looking at the extent to which the concentration of resistance in one or few Member States is likely to affect further integration under different decision making regimes (unanimity or qualified majority).