High incidence of ace-1 duplicated haplotypes in resistant Culex pipiens mosquitoes from Algeria - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Insect Biochemistry and Molecular Biology Année : 2011

High incidence of ace-1 duplicated haplotypes in resistant Culex pipiens mosquitoes from Algeria

Résumé

The status of genes conferring resistance to organophosphate and carbamate insecticides has been examined in Culex pipiens pipiens mosquitoes sampled in Algeria. Presence of overproduced esterases was sporadic, but acetylcholinesterase-1 resistant alleles were observed in almost all samples. We focused our study on the AChE1 G119S substitution characterized in almost all samples, mostly at the heterozygous state. A genetic test revealed the presence of ace-1 duplication associating a susceptible and a resistant ace-1 copy. Molecular characterization showed a high occurrence of ace-1 duplication with six distinct duplicated alleles out of four samples. The inferred frequency of duplicated allele suggests that it is replacing the single resistant G119S allele. Finally, we discuss the mechanism at the origin of these duplicated haplotypes and their consequences on the management of insecticide resistance. (C) 2010 Elsevier Ltd. All rights reserved.

Domaines

Fichier principal
Vignette du fichier
Alout et al., 2011_1.pdf (266.54 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

halsde-00633660 , version 1 (28-05-2020)

Identifiants

Citer

Haoues Alout, Pierrick Labbé, Nicole Pasteur, Mylène Weill. High incidence of ace-1 duplicated haplotypes in resistant Culex pipiens mosquitoes from Algeria. Insect Biochemistry and Molecular Biology, 2011, 41 (1), pp.29-35. ⟨10.1016/j.ibmb.2010.09.009⟩. ⟨halsde-00633660⟩
129 Consultations
106 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More