Dissection of a Y-autosome translocation in Cryptomys hottentotus (Rodentia, Bathyergidae) and implications for the evolution of a meiotic sex chromosome chain - Archive ouverte HAL
Article Dans Une Revue Chromosoma Année : 2008

Dissection of a Y-autosome translocation in Cryptomys hottentotus (Rodentia, Bathyergidae) and implications for the evolution of a meiotic sex chromosome chain

Résumé

We describe the outcome of a comprehensive cytogenetic survey of the common mole-rat, Cryptomys hottentotus, based on G and C banding, fluorescence in situ hybridisation and the analysis of meiotic chromosomes using immunostaining of proteins involved in the formation of synaptonemal complex (SCP1 and SCP3). We identified the presence of a Y-autosome translocation that is responsible for a fixed diploid number difference between males (2n=53) and females (2n=54), a character that likely defines the C. hottentotus lineage. Immunostaining, combined with C banding of spermatocytes, revealed a linearised sex trivalent with X-1 at one end and X-2 at the other, with evidence of reduced recombination between Y and X-2 that seems to be heterochromatin dependant in the C. hottentotus lineage. We suggest that this could depict the likely initial step in the differentiation of a true neo-X, and that this may mimic an early stage in the mammalian meiotic chain formation, an evolutionary process that has been taken to an extreme in a monotreme mammal, the platypus.

Dates et versions

halsde-00469789 , version 1 (02-04-2010)

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J. L. Deuve, N.C. Bennett, A. Ruiz-Herrera, P.D. Waters, Janice Britton-Davidian, et al.. Dissection of a Y-autosome translocation in Cryptomys hottentotus (Rodentia, Bathyergidae) and implications for the evolution of a meiotic sex chromosome chain. Chromosoma, 2008, 117 (2), pp.211-217. ⟨10.1007/s00412-007-0140-6⟩. ⟨halsde-00469789⟩
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