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Article Dans Une Revue Phytochemistry Année : 2008

Sesquiterpenes from aerial parts of Ferula vesceritensis

Résumé

From the dichloromethane extract of aerial parts of Ferula vesceritensis (Apiaceae), 11 sesquiterpene derivatives were isolated. Among them five were compounds designated as 10-hydroxylancerodiol-6- anisate, 2,10-diacetyl-8-hydroxyferutriol-6-anisate, 10-hydroxylancerodiol-6-benzoate, vesceritenone and epoxy-vesceritenol. The six known compounds were identified as feselol, farnesiferol A, lapidol, 2-acetyl-jaeschkeanadiol-6-anisate, lasidiol-10-anisate and 10-oxo-jaesckeanadiol-6-anisate. All the structures were determined by extensive spectroscopic studies including 1D and 2D NMR experiments and mass spectroscopy analysis. Two of the compounds, the sesquiterpene coumarins farnesiferol A and feselol, bound to the model recombinant nucleotide-binding site of an MDR-like efflux pump from the enteropathogenic protozoan Cryptosporidium parvum.

Dates et versions

halsde-00305195 , version 1 (23-07-2008)

Identifiants

Citer

Karima Oughlissi-Dehak, Philippe Lawton, Serge Michalet, Christine Bayet, Nicole Darbour, et al.. Sesquiterpenes from aerial parts of Ferula vesceritensis. Phytochemistry, 2008, 69, pp.1933-1938. ⟨10.1016/j.phytochem.2008.03.010⟩. ⟨halsde-00305195⟩
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