Testing the unique amplification event and the worldwide migration hypothesis of insecticide resistance genes with sequence data - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Heredity Année : 1996

Testing the unique amplification event and the worldwide migration hypothesis of insecticide resistance genes with sequence data

Résumé

In the mosquito Culex pipiens, over-production of esterases is a common insecticide resistance mechanism. Different alleles at the esterase A and B loci are known to occur in natural populations, as shown by enzyme electrophoresis and RFLP studies on the esterase B locus. Here we analyse the variability of the esterase A locus at the nucleotide level in mosquitoes possessing or lacking over-produced esterase A. A surprisingly high level of nucleotide polymorphism is found in coding and noncoding regions, and the extent of polymorphism detected is higher than that previously described for the most polymorphic loci in Drosophila. We also show that eight strains from different localities (Africa, America, Asia) that possess the over-produced esterase A2 share the same nucleotide sequence at the esterase A locus, strongly supporting the evolutionary scenario of a unique event of amplification of this gene followed by dispersal through migration rather than the occurrence of multiple independent mutational events of the gene.

Dates et versions

halsde-00201468 , version 1 (29-12-2007)

Identifiants

Citer

Thomas Guillemaud, S. Rooker, Nicole Pasteur, Michel Raymond. Testing the unique amplification event and the worldwide migration hypothesis of insecticide resistance genes with sequence data. Heredity, 1996, 77, pp.535-543. ⟨10.1038/hdy.1996.181⟩. ⟨halsde-00201468⟩
53 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More