Independent duplications of the acetylcholinesterase gene conferring insecticide resistance in the mosquito Culex pipiens - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular Biology and Evolution Année : 2007

Independent duplications of the acetylcholinesterase gene conferring insecticide resistance in the mosquito Culex pipiens

Résumé

Gene duplication is thought to be the main potential source of material for the evolution of new gene functions. Several models have been proposed for the evolution of new functions through duplication, most based on ancient events (Myr). We provide molecular evidence for the occurrence of several (at least 3) independent duplications of the ace-1 locus in the mosquito Culex pipiens, selected in response to insecticide pressure that probably occurred very recently (,40 years ago). This locus encodes the main target of several insecticides, the acetylcholinesterase. The duplications described consist of 2 alleles of ace-1, 1 susceptible and 1 resistant to insecticide, located on the same chromosome. These events were detected in different parts of the world and probably resulted from distinct mechanisms. We propose that duplications were selected because they reduce the fitness cost associated with the resistant ace-1 allele through the generation of persistent, advantageous heterozygosis. The rate of duplication of ace-1 in C. pipiens is probably underestimated, but seems to be rather high.
Fichier principal
Vignette du fichier
msm025.pdf (298.67 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

halsde-00186494 , version 1 (16-06-2021)

Licence

Paternité

Identifiants

Citer

Pierrick Labbé, Arnaud Berthomieu, Claire Berticat, Haoues Alout, Michel Raymond, et al.. Independent duplications of the acetylcholinesterase gene conferring insecticide resistance in the mosquito Culex pipiens. Molecular Biology and Evolution, 2007, 24 (4), pp.1056-1067. ⟨10.1093/molbev/msm025⟩. ⟨halsde-00186494⟩
119 Consultations
57 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More