<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05610559</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-06T03:14:19+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Liver Stiffness Characterization of OGT LKO Mouse Model of Progressive Liver Fibrosis</title>
            <author role="aut">
              <persName>
                <forename type="first">Gilles</forename>
                <surname>Renault</surname>
              </persName>
              <idno type="idhal" notation="numeric">1264103</idno>
              <idno type="halauthorid" notation="string">138618-1264103</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2273-1229</idno>
              <affiliation ref="#struct-1004701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lenin</forename>
                <surname>Chinchilla</surname>
              </persName>
              <idno type="halauthorid">1682655-0</idno>
              <affiliation ref="#struct-578126"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lourdes</forename>
                <surname>Massengo</surname>
              </persName>
              <idno type="halauthorid">4116857-0</idno>
              <affiliation ref="#struct-1004701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Monbernard</surname>
              </persName>
              <idno type="halauthorid">2573348-0</idno>
              <affiliation ref="#struct-1004701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fadila</forename>
                <surname>Benhamed</surname>
              </persName>
              <idno type="halauthorid">881600-0</idno>
              <affiliation ref="#struct-1004701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marion</forename>
                <surname>Régnier</surname>
              </persName>
              <email type="md5">97cc200ab47505fed705aeb6e1771f8d</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">marion-regnier</idno>
              <idno type="idhal" notation="numeric">1287504</idno>
              <idno type="halauthorid" notation="string">1987333-1287504</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5005-0597</idno>
              <affiliation ref="#struct-1004701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raphael</forename>
                <surname>Denis</surname>
              </persName>
              <idno type="idhal" notation="numeric">801933</idno>
              <idno type="halauthorid" notation="string">890238-801933</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7677-7460</idno>
              <affiliation ref="#struct-1004701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Postic</surname>
              </persName>
              <idno type="halauthorid">641008-0</idno>
              <affiliation ref="#struct-1004701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anthony</forename>
                <surname>Novell</surname>
              </persName>
              <email type="md5">2503333721d7308be3df3ef3333e7ace</email>
              <email type="domain">universite-paris-saclay.fr</email>
              <idno type="idhal" notation="string">novell-anthony</idno>
              <idno type="idhal" notation="numeric">739009</idno>
              <idno type="halauthorid" notation="string">40586-739009</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3649-0956</idno>
              <idno type="IDREF">https://www.idref.fr/180746170</idno>
              <affiliation ref="#struct-578126"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean‐luc</forename>
                <surname>Gennisson</surname>
              </persName>
              <email type="md5">9f0a4fc8f2939f93f4572893eba8fd65</email>
              <email type="domain">universite-paris-saclay.fr</email>
              <idno type="idhal" notation="string">jean-luc-gennisson</idno>
              <idno type="idhal" notation="numeric">747247</idno>
              <idno type="halauthorid" notation="string">2278063-747247</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8318-8237</idno>
              <idno type="IDREF">https://www.idref.fr/08942736X</idno>
              <affiliation ref="#struct-578126"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Marion</forename>
                <surname>Régnier</surname>
              </persName>
              <email type="md5">97cc200ab47505fed705aeb6e1771f8d</email>
              <email type="domain">inserm.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2026-05-04 11:46:44</date>
              <date type="whenModified">2026-05-06 03:12:40</date>
              <date type="whenReleased">2026-05-04 11:46:44</date>
              <date type="whenProduced">2025-12-04</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053628"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1495882">
                <persName>
                  <forename>Marion</forename>
                  <surname>Régnier</surname>
                </persName>
                <email type="md5">97cc200ab47505fed705aeb6e1771f8d</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05610559</idno>
            <idno type="halUri">https://hal.science/hal-05610559</idno>
            <idno type="halBibtex">renault:hal-05610559</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Ultrasound in Medicine&lt;/i&gt;, 2025, 45 (5), pp.1069-1082. &lt;a target="_blank" href="https://dx.doi.org/10.1002/jum.70146"&gt;&amp;#x27E8;10.1002/jum.70146&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Ultrasound in Medicine, 2025, 45 (5), pp.1069-1082. &amp;#x27E8;10.1002/jum.70146&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="CEA-UPSAY" corresp="CEA">CEA - Université Paris-Saclay</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="JOLIOT" corresp="CEA">Institut des Sciences du Vivant Frédéric JOLIOT</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="SHFJ" corresp="JOLIOT">Service Hospitalier Frédéric Joliot</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="GS-LIFE-SCIENCES-HEALTH" corresp="UNIVERSITE-PARIS-SACLAY">Graduate School Life Sciences and Health</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Liver Stiffness Characterization of OGT LKO Mouse Model of Progressive Liver Fibrosis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Gilles</forename>
                    <surname>Renault</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1264103</idno>
                  <idno type="halauthorid" notation="string">138618-1264103</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2273-1229</idno>
                  <affiliation ref="#struct-1004701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lenin</forename>
                    <surname>Chinchilla</surname>
                  </persName>
                  <idno type="halauthorid">1682655-0</idno>
                  <affiliation ref="#struct-578126"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lourdes</forename>
                    <surname>Massengo</surname>
                  </persName>
                  <idno type="halauthorid">4116857-0</idno>
                  <affiliation ref="#struct-1004701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Monbernard</surname>
                  </persName>
                  <idno type="halauthorid">2573348-0</idno>
                  <affiliation ref="#struct-1004701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fadila</forename>
                    <surname>Benhamed</surname>
                  </persName>
                  <idno type="halauthorid">881600-0</idno>
                  <affiliation ref="#struct-1004701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marion</forename>
                    <surname>Régnier</surname>
                  </persName>
                  <email type="md5">97cc200ab47505fed705aeb6e1771f8d</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">marion-regnier</idno>
                  <idno type="idhal" notation="numeric">1287504</idno>
                  <idno type="halauthorid" notation="string">1987333-1287504</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5005-0597</idno>
                  <affiliation ref="#struct-1004701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raphael</forename>
                    <surname>Denis</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">801933</idno>
                  <idno type="halauthorid" notation="string">890238-801933</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7677-7460</idno>
                  <affiliation ref="#struct-1004701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Postic</surname>
                  </persName>
                  <idno type="halauthorid">641008-0</idno>
                  <affiliation ref="#struct-1004701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anthony</forename>
                    <surname>Novell</surname>
                  </persName>
                  <email type="md5">2503333721d7308be3df3ef3333e7ace</email>
                  <email type="domain">universite-paris-saclay.fr</email>
                  <idno type="idhal" notation="string">novell-anthony</idno>
                  <idno type="idhal" notation="numeric">739009</idno>
                  <idno type="halauthorid" notation="string">40586-739009</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3649-0956</idno>
                  <idno type="IDREF">https://www.idref.fr/180746170</idno>
                  <affiliation ref="#struct-578126"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean‐luc</forename>
                    <surname>Gennisson</surname>
                  </persName>
                  <email type="md5">9f0a4fc8f2939f93f4572893eba8fd65</email>
                  <email type="domain">universite-paris-saclay.fr</email>
                  <idno type="idhal" notation="string">jean-luc-gennisson</idno>
                  <idno type="idhal" notation="numeric">747247</idno>
                  <idno type="halauthorid" notation="string">2278063-747247</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8318-8237</idno>
                  <idno type="IDREF">https://www.idref.fr/08942736X</idno>
                  <affiliation ref="#struct-578126"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">21813</idno>
                <idno type="issn">0278-4297</idno>
                <idno type="eissn">1550-9613</idno>
                <title level="j">Journal of Ultrasound in Medicine</title>
                <imprint>
                  <publisher>American Institute of Ultrasound in Medicine</publisher>
                  <biblScope unit="volume">45</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">1069-1082</biblScope>
                  <date type="datePub">2025-12-04</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1002/jum.70146</idno>
              <idno type="pubmed">41342519</idno>
              <idno type="pubmedcentral">PMC13053628</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">OGTLKO</term>
                <term xml:lang="en">liver fibrosis stage</term>
                <term xml:lang="en">liver stiffness</term>
                <term xml:lang="en">shear wave elastography</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Objectives O ‐GlcNAcylation plays a key regulatory role in hepatic physiology, and its disruption leads to fibrosis in liver‐specific OGT knockout mice (OGT LKO ), making this model valuable for studying advanced metabolic dysfunction‐associated steatohepatitis (MASH). Our objective is to demonstrate that shear wave elastography (SWE) is a suitable non‐invasive tool to characterize and follow this mouse model of liver injury. Methods We weekly monitored non‐invasively liver fibrosis progression in OGT LKO mice from 5 to 8 weeks of age, using SWE on both a high‐frequency preclinical ultrasound system (VevoF2), and a clinical reference system (Aixplorer) and assuming the liver as homogeneous, isotropic and purely elastic. Stiffness measurements were then confronted with ex vivo liver histological scoring and major gene transcripts associated with the development of the pathology. Results Weekly liver stiffness measurements demonstrated a progressive increase, correlating strongly with histological fibrosis scores ( R 2 &amp;gt; 0.78) and fibrosis‐related gene expression (Col3a1, Col6a1). The high‐resolution imaging capability of the VevoF2 allowed precise anatomical exploration while delivering SWE measurements consistent with the clinical device (Pearson r = 0.92). Conclusion Our study confirms that following liver stiffness fibrosis by SWE in a mouse model of liver injury is a valuable tool that correlates with ex vivo findings. This approach facilitates a better understanding of disease progression and therapeutic evaluation in preclinical models of MASH.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1004701" status="VALID">
          <idno type="IdRef">158485130</idno>
          <idno type="ISNI">0000 0004 0643 431X</idno>
          <idno type="RNSR">200217519N</idno>
          <idno type="ROR">https://ror.org/051sk4035</idno>
          <orgName>Institut Cochin</orgName>
          <orgName type="acronym">IC UM3 (UMR 8104 / U1016)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>22 rue Méchain, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cochin.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1016" active="#struct-303623" type="direct"/>
            <relation name="UMR8104" active="#struct-441569" type="direct"/>
            <relation name="UM 3" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-578126" status="VALID">
          <idno type="RNSR">202023520H</idno>
          <orgName>LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay</orgName>
          <orgName type="acronym">BIOMAPS</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>CEA - Service Hospitalier Frédéric Joliot . 4, place du Général Leclerc 91401 Orsay Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.biomaps.universite-paris-saclay.fr/</ref>
          </desc>
          <listRelation>
            <relation name="DRF/JOLIOT/SHFJ" active="#struct-40418" type="direct"/>
            <relation active="#struct-419361" type="indirect"/>
            <relation active="#struct-487603" type="indirect"/>
            <relation name="DRF" active="#struct-300016" type="indirect"/>
            <relation name="U1281" active="#struct-303623" type="direct"/>
            <relation name="UMR9011" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-40418" status="VALID">
          <idno type="RNSR">201722555X</idno>
          <orgName>Service Hospitalier Frédéric Joliot</orgName>
          <orgName type="acronym">SHFJ</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-419361" type="direct"/>
            <relation active="#struct-487603" type="direct"/>
            <relation name="DRF" active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-487603" status="VALID">
          <idno type="IdRef">262253712</idno>
          <idno type="RNSR">201722498K</idno>
          <idno type="ROR">https://ror.org/016pnwd02</idno>
          <idno type="Wikidata">Q61933008</idno>
          <orgName>Institut des Sciences du Vivant Frédéric JOLIOT</orgName>
          <orgName type="acronym">JOLIOT</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>DRFCEAGif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="DRF" active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>