Communication Dans Un Congrès Année : 2025

Post-reproductive neurodegeneration and “programmed” death of cuttlefish (Sepia officinalis) progenitors: consequences of an Alzheimer’s disease-type tauopathy?

Résumé

Cuttlefish (Sepia officinalis) are short life-span (20-22 months) cephalopods that show rapid CNS degeneration, known as post-reproductive degeneration. The immediate consequence is the abrupt cessation of egg-laying and the death of females that are still fertile. Aging manifests itself through behavioral and physiological alterations: loss of perception, inability to regulate bathymetry, motor decline and instinctual feeding disorders. While the hypotheses of neuroendocrine dysfunctioning and/or immune system failure cannot be ruled out, vertebrate-like CNS neurodegeneration is the major focus of the work carried out in this study. In this context, new CNS transcriptomes from cuttlefish at different stages of their life cycle were sequenced and subjected to analysis. They revealed 686 differentially expressed transcripts. In addition, in silico analysis revealed the expression of molecular markers associated with Alzheimer's disease, including amyloid-β peptide precursor (APP), Tau protein (involved in neurofibrillary tangles), as well as APP-cleaving enzymes (ADAM, BACE-1, PSEN). Immunolabeling with homologous antibodies showed variable distributions and abundances of some of these biomarkers in the CNS depending on the life cycle stage and correlated with post-reproductive decline. TEM observations of the synthetic Ab42 peptide in solution showed spontaneous organization into amyloid polymers similar to the organization described in vertebrates. These results support the hypothesis of a neurodegenerative mechanism shared between cuttlefish and vertebrates, involving molecular pathways analogous to those of Alzheimer's disease. The natural aggregation of Aβ peptide in cuttlefish and the spatio-temporal expression of the identified markers make it a major model for studying neurodegenerative processes.

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Dates et versions

hal-05549414 , version 1 (12-03-2026)

Identifiants

  • HAL Id : hal-05549414 , version 1

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Maureen Pred'Homme, Céline Zatylny-Gaudin, Nadège Villain-Naud, Marie-Pierre Dubos, Nicolas Elie, et al.. Post-reproductive neurodegeneration and “programmed” death of cuttlefish (Sepia officinalis) progenitors: consequences of an Alzheimer’s disease-type tauopathy?. CIAC (Cephalopod international Advisory Council), Oct 2025, Okinawa, Japan, Japan. ⟨hal-05549414⟩
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