Poster De Conférence Année : 2025

The cuttlefish $Sepia\ officinalis$: a relevant invertebrate model for the study of Alzheimer's disease?

Résumé

The common cuttlefish is a short life-span (20–22 months) cephalopod that exhibits rapid post-reproductive decline apparently linked to neurodegeneration. This is characteristic of semelparous species (species with a single reproductive event), through behavioral and physiological alterations: sensory loss, impaired bathymetric regulation, motor decline, and instinctual feeding disturbances. These observations suggest the involvement of neural biomarkers of aging in the central nervous system (CNS). In silico analysis of new CNS transcriptomes revealed the expression of molecular markers associated with Alzheimer's disease (AD), including amyloid-β peptide precursor (APP), Tau protein (implicated in neurofibrillary tangles), and APP-cleaving enzymes (ADAM, BACE-1, PSEN). Based on cuttlefish sequences identified in the neurotranscriptome, the Aβ1-42 peptide was synthesized and specific antibodies against Aβ1-42 were produced.

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Dates et versions

hal-05548904 , version 1 (12-03-2026)

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  • HAL Id : hal-05548904 , version 1

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Maureen Pred'Homme, Céline Zatylny-Gaudin, Nadège Villain-Naud, Marie-Pierre Dubos, Didier Goux, et al.. The cuttlefish $Sepia\ officinalis$: a relevant invertebrate model for the study of Alzheimer's disease?. FAAST 2025 - France Alzheimer Actualités Scientifiques et Thérapeutiques, Jun 2025, Paris, France. . ⟨hal-05548904⟩
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