The cuttlefish $Sepia\ officinalis$: a relevant invertebrate model for the study of Alzheimer's disease?
Résumé
The common cuttlefish is a short life-span (20–22 months) cephalopod that exhibits rapid post-reproductive decline apparently linked to neurodegeneration. This is characteristic of semelparous species (species with a single reproductive event), through behavioral and physiological alterations: sensory loss, impaired bathymetric regulation, motor decline, and instinctual feeding disturbances. These observations suggest the involvement of neural biomarkers of aging in the central nervous system (CNS). In silico analysis of new CNS transcriptomes revealed the expression of molecular markers associated with Alzheimer's disease (AD), including amyloid-β peptide precursor (APP), Tau protein (implicated in neurofibrillary tangles), and APP-cleaving enzymes (ADAM, BACE-1, PSEN). Based on cuttlefish sequences identified in the neurotranscriptome, the Aβ1-42 peptide was synthesized and specific antibodies against Aβ1-42 were produced.
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