Article Dans Une Revue British Journal of Cancer Année : 2016

Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study

Sanne Samuels
  • Fonction : Auteur
Balazs Balint
  • Fonction : Auteur
Heiko von der Leyen
  • Fonction : Auteur
Philippe Hupé
Leanne de Koning
  • Fonction : Auteur
Choumouss Kamoun
  • Fonction : Auteur
Windy Luscap-Rondof
  • Fonction : Auteur
Ulrike Wittkop
  • Fonction : Auteur
Ksenia Bagrintseva
  • Fonction : Auteur
Marina Popovic
  • Fonction : Auteur
Atttila Kereszt
  • Fonction : Auteur
Els Berns
  • Fonction : Auteur
Gemma G Kenter
  • Fonction : Auteur
Ekaterina S Jordanova
  • Fonction : Auteur
Maud Kamal
  • Fonction : Auteur
Susy Scholl
  • Fonction : Auteur

Résumé

BACKGROUND : Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality worldwide. CC pathogenesis is triggered when human papillomavirus (HPV) inserts into the genome, resulting in tumour suppressor gene inactivation and oncogene activation. Collecting tumour and blood samples is critical for identifying these genetic alterations. METHODS : BIO-RAIDs is the first prospective molecular profiling clinical study to include a substantial biobanking effort that used uniform high-quality standards and control of samples. In this European Union (EU)-funded study, we identified the challenges that were impeding the effective implementation of such a systematic and comprehensive biobanking effort. RESULTS : The challenges included a lack of uniform international legal and ethical standards, complexities in clinical and molecular data management, and difficulties in determining the best technical platforms and data analysis techniques. Some difficulties were encountered by all investigators, while others affected only certain institutions, regions, or countries. CONCLUSIONS : The results of the BIO-RAIDs programme highlight the need to facilitate and standardise regulatory procedures, and we feel that there is also a need for international working groups that make recommendations to regulatory bodies, governmental funding agencies, and academic institutions to achieve a proficient biobanking programme throughout EU countries. This represents the first step in precision medicine.

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hal-05544929 , version 1 (10-03-2026)

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Sanne Samuels, Balazs Balint, Heiko von der Leyen, Philippe Hupé, Leanne de Koning, et al.. Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study. British Journal of Cancer, 2016, 115 (12), ⟨10.1038/bjc.2016.340⟩. ⟨hal-05544929⟩
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