Sex-specific effects of different diets inducing MAFLD and treatment with the PPARα agonist elafibranor
Résumé
Background and aims: Metabolic associated fatty liver disease (MAFLD) is a liver disease characterized by fat accumulation and is often associated with obesity and type 2 diabetes. Recent studies suggest that sex may influence disease progression, although the underlying mechanisms remain unclear. This study aims to assess the sex-specific effects of different diets inducing MAFLD and the subsequent treatment with the PPARα agonist elafibranor, which has shown promising results in reducing disease severity and improving glucose homeostasis.