<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05498450</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T12:53:55+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Clinical Effects of Mixed Infection of Trypanosomes and Ancylostoma caninum in Dogs and Treatment with Diminazene and Mebendazole (Nigeria)</title>
            <author role="aut">
              <persName>
                <forename type="first">R. I. O</forename>
                <surname>Nwoha</surname>
              </persName>
              <idno type="halauthorid">3959037-0</idno>
              <affiliation ref="#struct-1766689"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B. M</forename>
                <surname>Anene</surname>
              </persName>
              <idno type="halauthorid">3959038-0</idno>
              <affiliation ref="#struct-1766690"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Review</forename>
                <surname>Molecular</surname>
              </persName>
              <email type="md5">91469e52e1d3f91e19ea37a90204076e</email>
              <email type="domain">outlook.com</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2026-02-07 06:48:27</date>
              <date type="whenModified">2026-02-07 06:48:27</date>
              <date type="whenReleased">2026-02-07 06:48:27</date>
              <date type="whenProduced">2015-10-17</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1740487">
                <persName>
                  <forename>Review</forename>
                  <surname>Molecular</surname>
                </persName>
                <email type="md5">91469e52e1d3f91e19ea37a90204076e</email>
                <email type="domain">outlook.com</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05498450</idno>
            <idno type="halUri">https://hal.science/hal-05498450</idno>
            <idno type="halBibtex">nwoha:hal-05498450</idno>
            <idno type="halRefHtml">&lt;i&gt;British Journal of Medicine and Medical Research&lt;/i&gt;, 2015, 11 (9), pp.1-10</idno>
            <idno type="halRef">British Journal of Medicine and Medical Research, 2015, 11 (9), pp.1-10</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt/>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Clinical Effects of Mixed Infection of Trypanosomes and Ancylostoma caninum in Dogs and Treatment with Diminazene and Mebendazole (Nigeria)</title>
                <author role="aut">
                  <persName>
                    <forename type="first">R. I. O</forename>
                    <surname>Nwoha</surname>
                  </persName>
                  <idno type="halauthorid">3959037-0</idno>
                  <affiliation ref="#struct-1766689"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B. M</forename>
                    <surname>Anene</surname>
                  </persName>
                  <idno type="halauthorid">3959038-0</idno>
                  <affiliation ref="#struct-1766690"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="INCOMING">1537595</idno>
                <idno type="issn">2231-0614</idno>
                <title level="j">British Journal of Medicine and Medical Research</title>
                <imprint>
                  <biblScope unit="volume">11</biblScope>
                  <biblScope unit="issue">9</biblScope>
                  <biblScope unit="pp">1-10</biblScope>
                  <date type="datePub">2015-10-17</date>
                </imprint>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="info.info-im">Computer Science [cs]/Medical Imaging</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The socio-economic importance of trypanosomosis and ancylostomosis in both humans and animal necessitated the investigation of the clinical signs of single and conjunct infection of both parasites in dogs. Sixteen dogs grouped into 4 of 4 members each were used in the study. GROUP I was uninfected dogs (control), GROUP II was infected with Ancylostoma caninum GROUP III was infected with Trypanosoma brucei (T. brucei), GROUP IV was mixed infections of Trypanosoma brucei and Ancylostoma caninum (T. brucei/A. caninum). Post acclimatization, Ancylostoma caninum infection was done on GPII and GPIV. Two weeks later Trypanosoma brucei infections was done on GPIII and superimposed on GPIV. Three weeks post trypanosome infection; GPIII and GPIV were treated with 7 mg/kg diminazene aceturate (Veribin®, CEVA Sante Animale- La Ballasteiére 33501 Libourne Cedex, France) x intramuscularly x once. Mebendazole (Vermin®, Janssen-Cilag Ltd 50 - 100 Holmers Farm Way, High Wycombe, Bucks, HP12 4EG UK)  at 100 mg x per os twice daily for 3 days was used only on GPII and GPIV and a repeat treatment given 2 weeks later. Prepatent period of T. brucei infection was 5.00±1.30 days in single infection and 3.00±1.40 days in conjunct infection of T. brucei and A. caninum. Persistent parasitaemia resulted in repeated treatment with diminazene aceturate at 7 mg/kg and mebendazole at 100 mg twice daily for 3 days. The predominant signs revealed include; fluctuation in weight, lethargy, vomition, enlargement of popliteal lymphnodes, pyrexia, oedema of lower jaw and ocular discharges, enlarged abdomen, anaemia, cornea opacity and slight emaciation. The clinical signs were most severe in GPIV compared to GPIII. The egg per gram of faeces (EPG) in GPII was significantly higher than the mixed infection (GPIV). Treatment only slightly improved clinical manifestations.In conclusion, most signs shown were consistent with trypanosomosis in dogs except abdominal enlargement which is a complication of A. caninum. Clinical signs therefore could serve as a diagnostic tool in the treatment of both conditions in dogs.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-1766689" status="INCOMING">
          <orgName>Department of Veterinary Medicine, Micheal Okpara University of Agriculture, Umudike, P.O.Box 824, Nigeria.</orgName>
          <desc>
            <address>
              <country key="NG"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1766690" status="INCOMING">
          <orgName>Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria</orgName>
          <desc>
            <address>
              <country key="NG"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>