Article Dans Une Revue European Heart Journal. Quality of Care and Clinical Outcomes Année : 2026

Evaluation of a combined symptom-based questionnaire and capillary natriuretic peptides testing for early detection of heart failure: a heart failure awareness days nationwide screening study (DEPIC FR)

Emmanuelle Berthelot
Nathan Mewton
Damien Logeart
  • Fonction : Auteur
Nicolas Mansencal
  • Fonction : Auteur
Annabelle Jagu
  • Fonction : Auteur
Anne-Céline Martin
  • Fonction : Auteur
Lise Legrand
  • Fonction : Auteur
Charles Fauvel
  • Fonction : Auteur
Erwan Donal
  • Fonction : Auteur
Gianluigi Savarese
Amina Rakisheva
Marco Metra
Marie Fertin
  • Fonction : Auteur
Frédérique Mouquet
Emmanuelle Vermes
  • Fonction : Auteur
Jérôme Costa
  • Fonction : Auteur
Mathieu Chacornac
  • Fonction : Auteur
Didier Romain
  • Fonction : Auteur
Marie-France Seronde
  • Fonction : Auteur
Barnabas Gellen
  • Fonction : Auteur
Benoît Lequeux
  • Fonction : Auteur
Michel Galinier
  • Fonction : Auteur
Florence Canoui Poitrine
  • Fonction : Auteur
Olivier Lairez
  • Fonction : Auteur
Jean-Michel Tartière
  • Fonction : Auteur
Mounira Kharoubi
  • Fonction : Auteur
Thibaud Damy

Résumé

Abstract Aims Early diagnosis of heart failure (HF) remains challenging, as symptoms are often nonspecific or absent. We aimed to evaluate the performance of a two-step screening strategy combining a symptom-based questionnaire—based on the acronym EPOF (dyspnoea, weight gain, oedema, fatigue in french)—and capillary NT-proBNP fingerstick testing to identify individuals with elevated cardiovascular risk or preclinical HF. Methods and results We screened 2,481 adults without known HF during a nationwide, community-based campaign held in 21 hospital cardiology centres across France. All participants underwent capillary NT-proBNP testing using a point-of-care assay. A threshold of >125 pg/mL, per ESC guidelines for ruling out HF in ambulatory settings, was exceeded in 419 individuals (16.9%), of whom 36.5% were asymptomatic. Conversely, 30.5% of those with NT-proBNP ≤125 pg/mL reported at least one symptom. Symptom-based screening alone had limited diagnostic accuracy for detecting NT-proBNP >125 pg/mL. The presence of ≥1 symptom yielded a sensitivity of 63.2% and a specificity of 42.4%. Dyspnoea was the most sensitive symptom (47.7%), while weight gain had the highest specificity (84.7%). In contrast, the absence of both symptoms and NT-proBNP elevation was associated with a high negative predictive value (85.4%). Among the 198 participants with NT-proBNP >125 pg/mL who underwent cardiologist-led evaluation, 40.9% were classified as symptomatic HF (Stage C), and 24.2% as preclinical HF (Stage B). Conclusion Combining symptom assessment with NT-proBNP testing improves early identification of at-risk individuals and may help uncover a significant proportion of undiagnosed or early-stage HF.

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Dates et versions

hal-05450746 , version 1 (09-01-2026)

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Citer

Emmanuelle Berthelot, Nathan Mewton, François Roubille, Damien Logeart, Nicolas Mansencal, et al.. Evaluation of a combined symptom-based questionnaire and capillary natriuretic peptides testing for early detection of heart failure: a heart failure awareness days nationwide screening study (DEPIC FR). European Heart Journal. Quality of Care and Clinical Outcomes, 2026, ⟨10.1093/ehjqcco/qcaf164⟩. ⟨hal-05450746⟩
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