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            <funder>During its execution, this study was sponsored by Baxter Healthcare Corporation, the manufacturer of PRISMALUNG + and PRISMAX. Baxter’s Kidney Care segment is now a standalone vital organ therapy company called Vantive Healthcare.</funder>
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            <idno type="halRefHtml">&lt;i&gt;Critical Care&lt;/i&gt;, 2026, 30 (1), pp.15. &lt;a target="_blank" href="https://dx.doi.org/10.1186/s13054-025-05827-4"&gt;&amp;#x27E8;10.1186/s13054-025-05827-4&amp;#x27E9;&lt;/a&gt;</idno>
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                <title xml:lang="en">A prospective clinical evaluation of new ECCO2R technology in mild to moderate ARDS patients: assessing ultra-lung-protective ventilation with PRISMALUNG+</title>
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                    <forename type="first">Alain</forename>
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                    <forename type="first">Romain</forename>
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                    <forename type="first">Vincent</forename>
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                    <surname>Montgomery</surname>
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                    <surname>Parreno</surname>
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                <title level="j">Critical Care</title>
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                  <publisher>BioMed Central</publisher>
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                <term xml:lang="en">Acute respiratory distress syndrome</term>
                <term xml:lang="en">Extracorporeal carbon dioxide removal</term>
                <term xml:lang="en">Mechanical ventilation</term>
                <term xml:lang="en">Protective ventilation</term>
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              <p>BackgroundExtracorporeal carbon dioxide removal (ECCO2R), when used as an adjunct to mechanical ventilation in patients with mild to moderate acute respiratory distress syndrome (ARDS), has been proposed as a strategy to control hypercapnic acidosis during ultra-lung-protective ventilation (ULPV). However, no multicenter study has systematically assessed ventilation improvement markers with a standardized protocol using ECCO₂R devices featuring a peristaltic pump design. This prospective, multicenter study conducted in France addresses these gaps by evaluating the performance and safety of PRISMALUNG+, a novel membrane lung specifically developed for ECCO2R, either as a standalone therapy or combined with continuous renal replacement therapy (CRRT). A specific protocol for ULPV was used to minimize lung stress and mitigate the risk of hypoxemia.MethodsBetween April 2021 and December 2023, 58 patients were treated with ECCO2R (16 in combination with CRRT). Tidal volume (VT) was reduced stepwise from 6 mL/kg to 4 mL/kg. Once the partial pressure of carbon dioxide (PaCO2) exceeded 50 mmHg, sweep gas (100% oxygen at 10 L/min) was initiated to provide ECCO2R. Outcomes were measured at 8 and 24 h, while safety was monitored until discharge or day 28.ResultsDuring VT reduction and before ECCO2R initiation, peak hypercapnia and respiratory acidosis reached PaCO2 of 53.0 [50.0–55.0] mmHg and pH of 7.30 [7.24–7.36]. After 24 h of treatment, VT significantly decreased from 6.0 [6.0-6.1] to 4.0 [4.0-4.30] (p &amp;lt; 0.0001), driving pressure (∆P) from 12.0 [10.0–16.0] cmH2O to 10.0 [8.0–13.0] cmH2O (p &amp;lt; 0.0001), ventilatory ratio (VR) from 1.7 [1.5–2.1] to 1.3 [1.0-1.6] (p &amp;lt; 0.0001) and mechanical power from 18.8 [15.0–22.0] J/min to 11.8 [8.8–15.5] J/min (p &amp;lt; 0.0001). PaO2/FiO2 did not significantly change over time and respiratory acidosis resolved with treatment, as evidenced by normalization of pH and a reduction in PaCO2. Importantly, no major bleeding events, intracranial hemorrhages, or hemolysis were reported during the study.ConclusionThis study demonstrates that hypercapnic acidosis occurring during ultra-low VT ventilation (ULPV) can be safely mitigated with ECCO₂R in mechanically ventilated patients with mild to moderate ARDS. Moreover, under ULPV, ∆P, VR and mechanical power were improved without inducing hypoxemia.</p>
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