<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05425680</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-13T12:27:27+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Guidelines for Lyme borreliosis: treatment</title>
            <author role="crp">
              <persName>
                <forename type="first">Alice</forename>
                <surname>Raffetin</surname>
              </persName>
              <email type="md5">7518ffcb1be726d21952fe67ac05ca68</email>
              <email type="domain">chiv.fr</email>
              <idno type="idhal" notation="numeric">1270150</idno>
              <idno type="halauthorid" notation="string">1983429-1270150</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5003-540X</idno>
              <affiliation ref="#struct-507095"/>
              <affiliation ref="#struct-353882"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">France</forename>
                <surname>Roblot</surname>
              </persName>
              <email type="md5">9c9e038e13d793d513dc0e23ecb40539</email>
              <email type="domain">chu-poitiers.fr</email>
              <idno type="idhal" notation="numeric">1120181</idno>
              <idno type="halauthorid" notation="string">923386-1120181</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4325-023X</idno>
              <idno type="IDREF">https://www.idref.fr/058596178</idno>
              <idno type="VIAF">https://viaf.org/viaf/203837394</idno>
              <affiliation ref="#struct-1094387"/>
              <affiliation ref="#struct-108271"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cédric</forename>
                <surname>Lenormand</surname>
              </persName>
              <email type="md5">b70cd36413992052d9e569f3f1d078fc</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="numeric">1101417</idno>
              <idno type="halauthorid" notation="string">1799482-1101417</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0501-5212</idno>
              <idno type="IDREF">https://www.idref.fr/128764996</idno>
              <affiliation ref="#struct-1188830"/>
              <affiliation ref="#struct-187005"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yves</forename>
                <surname>Hansmann</surname>
              </persName>
              <email type="md5">eb6310aca0be374ac4a50459ab7be0a1</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="numeric">1065730</idno>
              <idno type="halauthorid" notation="string">2524914-1065730</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8903-0027</idno>
              <idno type="IDREF">https://www.idref.fr/07402311X</idno>
              <affiliation ref="#struct-187005"/>
              <affiliation ref="#struct-1003047"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elisabeth</forename>
                <surname>Baux</surname>
              </persName>
              <idno type="idhal" notation="numeric">791062</idno>
              <idno type="halauthorid" notation="string">1343983-791062</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2118-7751</idno>
              <affiliation ref="#struct-245658"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Steve</forename>
                <surname>Nguala</surname>
              </persName>
              <idno type="idhal" notation="numeric">1317312</idno>
              <idno type="halauthorid" notation="string">2298417-1317312</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0788-6898</idno>
              <affiliation ref="#struct-353882"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Tattevin</surname>
              </persName>
              <email type="md5">7b5084e6d239800d93aa10c1210aaf5b</email>
              <email type="domain">chu-rennes.fr</email>
              <idno type="idhal" notation="numeric">945604</idno>
              <idno type="halauthorid" notation="string">155165-945604</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3617-5411</idno>
              <idno type="IDREF">https://www.idref.fr/057598207</idno>
              <affiliation ref="#struct-480855"/>
              <affiliation ref="#struct-301327"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chantal</forename>
                <surname>Sobas</surname>
              </persName>
              <idno type="idhal" notation="numeric">1626345</idno>
              <idno type="halauthorid" notation="string">2532100-1626345</idno>
              <idno type="ORCID">https://orcid.org/0009-0004-7000-7133</idno>
              <idno type="IDREF">https://www.idref.fr/111747236</idno>
              <idno type="VIAF">https://viaf.org/viaf/191820201</idno>
              <idno type="ISNI">http://isni.org/isni/0000000139428053</idno>
              <affiliation ref="#struct-300074"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hans</forename>
                <surname>Yssel</surname>
              </persName>
              <email type="md5">80a6bb1bd3087b022145dec920ba78c8</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">757549</idno>
              <idno type="halauthorid" notation="string">2542091-757549</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7454-1836</idno>
              <idno type="IDREF">https://www.idref.fr/06683368X</idno>
              <affiliation ref="#struct-542033"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aude</forename>
                <surname>Gautier</surname>
              </persName>
              <idno type="halauthorid">36844-0</idno>
              <affiliation ref="#struct-184290"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pablo</forename>
                <surname>Arias</surname>
              </persName>
              <idno type="idhal" notation="numeric">1217194</idno>
              <idno type="halauthorid" notation="string">973884-1217194</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0481-7563</idno>
              <affiliation ref="#struct-353882"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kevin</forename>
                <surname>Bouiller</surname>
              </persName>
              <email type="md5">b653912b33fe1da4f4e7b6efcf0b6b82</email>
              <email type="domain">chu-besancon.fr</email>
              <idno type="idhal" notation="string">kevin-bouiller</idno>
              <idno type="idhal" notation="numeric">785201</idno>
              <idno type="halauthorid" notation="string">2093579-785201</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2177-4318</idno>
              <affiliation ref="#struct-57629"/>
              <affiliation ref="#struct-300165"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
            <funder>None</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-12-19 11:26:39</date>
              <date type="whenModified">2026-05-13 03:27:11</date>
              <date type="whenReleased">2025-12-19 11:26:39</date>
              <date type="whenProduced">2025-12</date>
              <ref type="externalLink" target="https://doi.org/10.1016/j.idnow.2025.105204"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05425680</idno>
            <idno type="halUri">https://hal.science/hal-05425680</idno>
            <idno type="halBibtex">raffetin:hal-05425680</idno>
            <idno type="halRefHtml">&lt;i&gt;Infectious Diseases Now&lt;/i&gt;, 2025, 55 (8S), pp.105204. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.idnow.2025.105204"&gt;&amp;#x27E8;10.1016/j.idnow.2025.105204&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Infectious Diseases Now, 2025, 55 (8S), pp.105204. &amp;#x27E8;10.1016/j.idnow.2025.105204&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="ANSES">Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-POITIERS">Université de Poitiers</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="UPEC" corresp="CV_UPEC">Université Paris-Est Créteil Val-de-Marne</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="CIMI" corresp="SORBONNE-UNIVERSITE">Centre d'Immunologie et des Maladies Infectieuses</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="ENVA">Ecole Nationale Vétérinaire d'Alfort</idno>
            <idno type="stamp" n="PHAR">Pharmacologie des anti-infectieux et antibiorésistance</idno>
            <idno type="stamp" n="DYNAMIC" corresp="UPEC">Dynamic Microbiology</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="INEE-CNRS">Institut écologie et environnement du CNRS</idno>
            <idno type="stamp" n="BRM">BRM - Inserm U 1230 - ARN régulateurs bactériens et médecine</idno>
            <idno type="stamp" n="HAS-SANTE">Haute Autorité de Santé</idno>
            <idno type="stamp" n="SUPRA_-SVE6">SVE6 - Maladies humaines</idno>
            <idno type="stamp" n="TEST-UPEC-ODD" corresp="UPEC">TEST UPEC ODD</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
            <idno type="stamp" n="PHAVI">Pathogens Host Arthropod Vectors Interfaces</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Guidelines for Lyme borreliosis: treatment</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Alice</forename>
                    <surname>Raffetin</surname>
                  </persName>
                  <email type="md5">7518ffcb1be726d21952fe67ac05ca68</email>
                  <email type="domain">chiv.fr</email>
                  <idno type="idhal" notation="numeric">1270150</idno>
                  <idno type="halauthorid" notation="string">1983429-1270150</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5003-540X</idno>
                  <affiliation ref="#struct-507095"/>
                  <affiliation ref="#struct-353882"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">France</forename>
                    <surname>Roblot</surname>
                  </persName>
                  <email type="md5">9c9e038e13d793d513dc0e23ecb40539</email>
                  <email type="domain">chu-poitiers.fr</email>
                  <idno type="idhal" notation="numeric">1120181</idno>
                  <idno type="halauthorid" notation="string">923386-1120181</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4325-023X</idno>
                  <idno type="IDREF">https://www.idref.fr/058596178</idno>
                  <idno type="VIAF">https://viaf.org/viaf/203837394</idno>
                  <affiliation ref="#struct-1094387"/>
                  <affiliation ref="#struct-108271"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cédric</forename>
                    <surname>Lenormand</surname>
                  </persName>
                  <email type="md5">b70cd36413992052d9e569f3f1d078fc</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="numeric">1101417</idno>
                  <idno type="halauthorid" notation="string">1799482-1101417</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0501-5212</idno>
                  <idno type="IDREF">https://www.idref.fr/128764996</idno>
                  <affiliation ref="#struct-1188830"/>
                  <affiliation ref="#struct-187005"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yves</forename>
                    <surname>Hansmann</surname>
                  </persName>
                  <email type="md5">eb6310aca0be374ac4a50459ab7be0a1</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="numeric">1065730</idno>
                  <idno type="halauthorid" notation="string">2524914-1065730</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8903-0027</idno>
                  <idno type="IDREF">https://www.idref.fr/07402311X</idno>
                  <affiliation ref="#struct-187005"/>
                  <affiliation ref="#struct-1003047"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elisabeth</forename>
                    <surname>Baux</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">791062</idno>
                  <idno type="halauthorid" notation="string">1343983-791062</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2118-7751</idno>
                  <affiliation ref="#struct-245658"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Steve</forename>
                    <surname>Nguala</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1317312</idno>
                  <idno type="halauthorid" notation="string">2298417-1317312</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0788-6898</idno>
                  <affiliation ref="#struct-353882"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Tattevin</surname>
                  </persName>
                  <email type="md5">7b5084e6d239800d93aa10c1210aaf5b</email>
                  <email type="domain">chu-rennes.fr</email>
                  <idno type="idhal" notation="numeric">945604</idno>
                  <idno type="halauthorid" notation="string">155165-945604</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3617-5411</idno>
                  <idno type="IDREF">https://www.idref.fr/057598207</idno>
                  <affiliation ref="#struct-480855"/>
                  <affiliation ref="#struct-301327"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chantal</forename>
                    <surname>Sobas</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1626345</idno>
                  <idno type="halauthorid" notation="string">2532100-1626345</idno>
                  <idno type="ORCID">https://orcid.org/0009-0004-7000-7133</idno>
                  <idno type="IDREF">https://www.idref.fr/111747236</idno>
                  <idno type="VIAF">https://viaf.org/viaf/191820201</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000139428053</idno>
                  <affiliation ref="#struct-300074"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hans</forename>
                    <surname>Yssel</surname>
                  </persName>
                  <email type="md5">80a6bb1bd3087b022145dec920ba78c8</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">757549</idno>
                  <idno type="halauthorid" notation="string">2542091-757549</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7454-1836</idno>
                  <idno type="IDREF">https://www.idref.fr/06683368X</idno>
                  <affiliation ref="#struct-542033"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aude</forename>
                    <surname>Gautier</surname>
                  </persName>
                  <idno type="halauthorid">36844-0</idno>
                  <affiliation ref="#struct-184290"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pablo</forename>
                    <surname>Arias</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1217194</idno>
                  <idno type="halauthorid" notation="string">973884-1217194</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0481-7563</idno>
                  <affiliation ref="#struct-353882"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kevin</forename>
                    <surname>Bouiller</surname>
                  </persName>
                  <email type="md5">b653912b33fe1da4f4e7b6efcf0b6b82</email>
                  <email type="domain">chu-besancon.fr</email>
                  <idno type="idhal" notation="string">kevin-bouiller</idno>
                  <idno type="idhal" notation="numeric">785201</idno>
                  <idno type="halauthorid" notation="string">2093579-785201</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2177-4318</idno>
                  <affiliation ref="#struct-57629"/>
                  <affiliation ref="#struct-300165"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">241535</idno>
                <idno type="issn">2666-9927</idno>
                <idno type="eissn">2666-9919</idno>
                <title level="j">Infectious Diseases Now</title>
                <imprint>
                  <publisher>Elsevier Masson [2021-....]</publisher>
                  <biblScope unit="volume">55</biblScope>
                  <biblScope unit="issue">8S</biblScope>
                  <biblScope unit="pp">105204</biblScope>
                  <date type="datePub">2025-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.idnow.2025.105204</idno>
              <idno type="pubmed">41314469</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Doxycycline</term>
                <term xml:lang="en">Challenging treatment</term>
                <term xml:lang="en">Ceftriaxone</term>
                <term xml:lang="en">Antibiotic therapy</term>
                <term xml:lang="en">Follow-up</term>
              </keywords>
              <classCode scheme="mesh">Anti-Bacterial Agents* / therapeutic use</classCode>
              <classCode scheme="mesh">Child</classCode>
              <classCode scheme="mesh">Pregnancy</classCode>
              <classCode scheme="mesh">Doxycycline / therapeutic use</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Lyme Disease* / diagnosis</classCode>
              <classCode scheme="mesh">Lyme Disease* / drug therapy</classCode>
              <classCode scheme="mesh">Lyme Neuroborreliosis / diagnosis</classCode>
              <classCode scheme="mesh">Lyme Neuroborreliosis / drug therapy</classCode>
              <classCode scheme="mesh">Practice Guidelines as Topic</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The aim of the clinical practice guideline is to support healthcare professionals in the diagnosis and management of patients with proven or suspected Lyme borreliosis (LB). The guideline provides an evidence-based algorithm for antibiotic therapy in confirmed LB cases and outlines recommendations for complex presentations where the three diagnostic criteria are not fully met, suggesting a possible challenge antibiotic therapy in specialized settings. Updated in accordance with international literature and previous French recommendations (HAS, 2022), the guidelines detail antibiotic selection and treatment duration according to clinical manifestations. Doxycycline remains the first-line treatment in most situations, including for children under eight years and pregnant or breastfeeding women. Treatment duration varies from 10 to 28 days depending on disease presentation: 10 days for isolated erythema migrans, 14 days for multiple erythema migrans or early neuroborreliosis, 21 days for lymphocytoma or late neuroborreliosis, and 28 days for Lyme arthritis or acrodermatitis chronica atrophicans. Longer treatments are not justified. In complex or recurrent cases, referral to a reference center is recommended. The guideline discourages the use of anti-inflammatory drugs in acute LB management and notes that corticosteroids do not worsen Lyme-related peripheral facial palsy. European treatment recommendations remain largely consistent across countries.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-507095" status="VALID">
          <idno type="IdRef">278982778</idno>
          <idno type="RNSR">201521846K</idno>
          <idno type="ROR">https://ror.org/01htygx54</idno>
          <idno type="Wikidata">Q51780402</idno>
          <orgName>Dynamic Microbiology - EA 7380</orgName>
          <orgName type="acronym">DYNAMIC</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine. 8 rue du Général Sarrail - 94020 Créteil</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://dynamyc.fr/</ref>
          </desc>
          <listRelation>
            <relation name="EA7380" active="#struct-34256" type="direct"/>
            <relation active="#struct-301715" type="direct"/>
            <relation active="#struct-303005" type="direct"/>
            <relation name="EA7380" active="#struct-420786" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353882" status="VALID">
          <idno type="ROR">https://ror.org/04deknx22</idno>
          <orgName>Centre Hospitalier Intercommunal Villeneuve-Saint-Georges</orgName>
          <orgName type="acronym">CHIV</orgName>
          <desc>
            <address>
              <addrLine>40 Allée de la Source,94195 Villeneuve-Saint-Georges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://chiv.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1094387" status="VALID">
          <idno type="RNSR">201220154J</idno>
          <idno type="ROR">https://ror.org/041v99f68</idno>
          <idno type="Wikidata">Q51779859</idno>
          <orgName>Pharmacologie des anti-infectieux et antibiorésistance [U 1070]</orgName>
          <orgName type="acronym">PHAR2 [Poitiers]</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Pôle Biologie Santé - Université de Poitiers - Bâtiment B36 - 1 rue Georges Bonnet - TSA 51106 - 86073 Poitiers Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://phar.labo.univ-poitiers.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR-S 1070" active="#struct-54493" type="direct"/>
            <relation name="U1070" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-108271" status="VALID">
          <idno type="IdRef">034799990</idno>
          <idno type="ISNI">0000000121696383</idno>
          <orgName>Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie]</orgName>
          <orgName type="acronym">UFR Santé [Poitiers]</orgName>
          <date type="start">1968-10-01</date>
          <desc>
            <address>
              <addrLine>Bâtiment D1 – 6 rue de la Milétrie – TSA 51 115 – 86073 Poitiers Cedex 9 – France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://medphar.univ-poitiers.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-54493" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1188830" status="VALID">
          <idno type="IdRef">275459543</idno>
          <idno type="RNSR">202424458K</idno>
          <idno type="Wikidata">Q125762018</idno>
          <orgName>Pathogens Host Arthropod Vectors Interfaces</orgName>
          <orgName type="acronym">PHAVI</orgName>
          <date type="start">2024-01-01</date>
          <desc>
            <address>
              <addrLine>Institut de parasitologie, 3 rue Koeberlé 67000 Strasbourg</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UR3073" active="#struct-199013" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-187005" status="VALID">
          <orgName>Service de dermatologie [Strasbourg]</orgName>
          <desc>
            <address>
              <addrLine>1, place de l'hôpital, F-67091 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300149" type="direct"/>
            <relation active="#struct-211628" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1003047" status="OLD">
          <idno type="IdRef">176972307</idno>
          <idno type="RNSR">201320504K</idno>
          <idno type="Wikidata">Q51781206</idno>
          <orgName>Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë</orgName>
          <orgName type="acronym">VBP</orgName>
          <date type="start">2013-01-01</date>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>Institut de bactériologie3 rue Koeberlé67000 Strasbourg</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UR7290" active="#struct-199013" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-245658" status="VALID">
          <orgName>Service des Maladies Infectieuses et Tropicales [CHRU Nancy]</orgName>
          <desc>
            <address>
              <addrLine>Vandœuvre-lès-Nancy</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-480855" status="VALID">
          <idno type="IdRef">179960938</idno>
          <idno type="RNSR">200817513F</idno>
          <idno type="ROR">https://ror.org/031y0x195</idno>
          <orgName>ARN bactériens et médecine</orgName>
          <orgName type="acronym">BRM</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Pharmacie - Campus Santé Villejean - 2, avenue Prof. Léon Bernard - Bâtiment 5 - 2e étage - CS 34317 - 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biochpharma.univ-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation name="U1230 / UMR1230" active="#struct-303623" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-542033" status="VALID">
          <idno type="RNSR">201420916D</idno>
          <idno type="ROR">0375b8f90</idno>
          <orgName>Centre d'Immunologie et des Maladies Infectieuses</orgName>
          <orgName type="acronym">CIMI</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>91 Boulevard de l'hôpital 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cimi-paris.upmc.fr</ref>
          </desc>
          <listRelation>
            <relation name="U1135" active="#struct-303623" type="direct"/>
            <relation name="UMRS_1135" active="#struct-413221" type="direct"/>
            <relation name="EMR8255 / ERL8255" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-184290" status="VALID">
          <orgName>Haute Autorité de Santé [Saint-Denis La Plaine]</orgName>
          <orgName type="acronym">HAS</orgName>
          <desc>
            <address>
              <addrLine>2, avenue du Stade de France, 93218 Saint-Denis La Plaine Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.has-sante.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-57629" status="VALID">
          <idno type="IdRef">166212377</idno>
          <idno type="ISNI">0000000103609610</idno>
          <idno type="RNSR">200812285Y</idno>
          <idno type="ROR">https://ror.org/028cef883</idno>
          <orgName>Laboratoire Chrono-environnement (UMR 6249)</orgName>
          <orgName type="acronym">LCE</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>16, route de Gray - 25030 Besançon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://chrono-environnement.univ-fcomte.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR6249" active="#struct-441569" type="direct"/>
            <relation active="#struct-458810" type="direct"/>
            <relation active="#struct-426438" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300165" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Besançon</orgName>
          <orgName type="acronym">CHRU Besançon</orgName>
          <desc>
            <address>
              <addrLine>3, boulevard A. Fleming - 25030 Besançon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-besancon.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-34256" status="VALID">
          <idno type="ROR">https://ror.org/04k031t90</idno>
          <orgName>École nationale vétérinaire d'Alfort</orgName>
          <orgName type="acronym">ENVA</orgName>
          <desc>
            <address>
              <addrLine>7 avenue du Général de Gaulle - 94700 Maisons-Alfort</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vet-alfort.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301715" status="VALID">
          <idno type="IdRef">148269761</idno>
          <idno type="ISNI">0000 0001 0584 7022</idno>
          <idno type="ROR">https://ror.org/0471kz689</idno>
          <idno type="Wikidata">Q392520</idno>
          <orgName>Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail</orgName>
          <orgName type="acronym">ANSES</orgName>
          <date type="start">2010-07-01</date>
          <desc>
            <address>
              <addrLine>14 rue Pierre et Marie Curie94701 MAISONS-ALFORT Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-303005" status="VALID">
          <idno type="ROR">https://ror.org/0268ecp52</idno>
          <orgName>Université Paris-Est</orgName>
          <orgName type="acronym">UPE</orgName>
          <desc>
            <address>
              <addrLine>6-8 avenue Blaise-PascalCité Descartes - Champs-sur-Marne77455 Marne-la-Vallée</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-est.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-420786" status="VALID">
          <idno type="IdRef">028021037</idno>
          <idno type="ISNI">0000000121497878</idno>
          <idno type="ROR">https://ror.org/05ggc9x40</idno>
          <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName>
          <orgName type="acronym">UPEC UP12</orgName>
          <date type="start">1970-01-01</date>
          <desc>
            <address>
              <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-pec.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-54493" status="VALID">
          <idno type="IdRef">026403765</idno>
          <idno type="ISNI">0000000121606368</idno>
          <idno type="ROR">https://ror.org/04xhy8q59</idno>
          <idno type="Wikidata">Q661056</idno>
          <orgName>Université de Poitiers =  University of Poitiers</orgName>
          <orgName type="acronym">UP</orgName>
          <desc>
            <address>
              <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-poitiers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300149" status="VALID">
          <orgName>Centre Hospitalier Universitaire [Strasbourg]</orgName>
          <orgName type="acronym">CHU Strasbourg</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-strasbourg.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-211628" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-211628" status="VALID">
          <idno type="IdRef">030378842</idno>
          <idno type="ROR">https://ror.org/04bckew43</idno>
          <orgName>Hôpitaux Universitaires de Strasbourg</orgName>
          <orgName type="acronym">HUS</orgName>
          <desc>
            <address>
              <addrLine>1 place de l'hôpital BP 426 67091 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-strasbourg.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300157" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Nancy</orgName>
          <orgName type="acronym">CHRU Nancy</orgName>
          <desc>
            <address>
              <addrLine>Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXHôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 NancyHôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-NancyMaternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-453207" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes</orgName>
          <orgName type="acronym">Biosit : Biologie - Santé - Innovation Technologique</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rennes - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-458810" status="VALID">
          <idno type="IdRef">026403188</idno>
          <idno type="ISNI">0000000121883779</idno>
          <idno type="ROR">https://ror.org/03pcc9z86</idno>
          <orgName>Université Marie et Louis Pasteur</orgName>
          <orgName type="acronym">UMLP</orgName>
          <desc>
            <address>
              <addrLine>1 rue Goudimel25030 Besançon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.umlp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-426438" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-426438" status="VALID">
          <idno type="IdRef">200716271</idno>
          <idno type="ISNI">0000 0004 4910 6615</idno>
          <idno type="ROR">https://ror.org/02dn7x778</idno>
          <orgName>Université Bourgogne Franche-Comté [COMUE]</orgName>
          <orgName type="acronym">UBFC</orgName>
          <date type="start">2015-04-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>32, avenue de l’observatoire25000 BESANCON</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ubfc.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>