<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05379217</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T10:50:40+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Advanced combination therapy in inflammatory bowel disease</title>
            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Morizot</surname>
              </persName>
              <email type="md5">63747db0878f6b1480f5192dea691902</email>
              <email type="domain">chru-nancy.fr</email>
              <idno type="idhal" notation="string">caroline-morizot</idno>
              <idno type="idhal" notation="numeric">1443789</idno>
              <idno type="halauthorid" notation="string">2000284-1443789</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3512-2409</idno>
              <affiliation ref="#struct-300157"/>
              <affiliation ref="#struct-1196526"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Léa</forename>
                <surname>Sequier</surname>
              </persName>
              <idno type="halauthorid">3445871-0</idno>
              <affiliation ref="#struct-493422"/>
              <affiliation ref="#struct-303483"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Yves</forename>
                <surname>Jouzeau</surname>
              </persName>
              <email type="md5">0306723518f8b174c97de4dda18ef8fd</email>
              <email type="domain">univ-lorraine.fr</email>
              <idno type="idhal" notation="string">jean-yves-jouzeau</idno>
              <idno type="idhal" notation="numeric">17914</idno>
              <idno type="halauthorid" notation="string">10369-17914</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2429-945X</idno>
              <idno type="IDREF">https://www.idref.fr/070287376</idno>
              <affiliation ref="#struct-1196526"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Moulin</surname>
              </persName>
              <email type="md5">3e4dd93a12f5e452d2286ca2e92961fb</email>
              <email type="domain">univ-lorraine.fr</email>
              <idno type="idhal" notation="string">david-moulin</idno>
              <idno type="idhal" notation="numeric">17909</idno>
              <idno type="halauthorid" notation="string">33670-17909</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-3849-2014</idno>
              <idno type="IDREF">https://www.idref.fr/096283408</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6619-5769</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/J-3849-2014</idno>
              <affiliation ref="#struct-1196526"/>
              <affiliation ref="#struct-300157"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <surname>Netter</surname>
              </persName>
              <email type="md5">85401f29482533893fe4bf75b6000a98</email>
              <email type="domain">yahoo.fr</email>
              <idno type="idhal" notation="numeric">853560</idno>
              <idno type="halauthorid" notation="string">170617-853560</idno>
              <idno type="IDREF">https://www.idref.fr/060277688</idno>
              <affiliation ref="#struct-1196526"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bénédicte</forename>
                <surname>Caron</surname>
              </persName>
              <idno type="halauthorid">2268319-0</idno>
              <affiliation ref="#struct-409232"/>
              <affiliation ref="#struct-300157"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sailish</forename>
                <surname>Honap</surname>
              </persName>
              <idno type="halauthorid">3445872-0</idno>
              <affiliation ref="#struct-1227244"/>
              <affiliation ref="#struct-327716"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Damien</forename>
                <surname>Loeuille</surname>
              </persName>
              <email type="md5">1eaad1aa6281e3a2320697b3db1c222e</email>
              <email type="domain">chu-nancy.fr</email>
              <idno type="idhal" notation="numeric">762400</idno>
              <idno type="halauthorid" notation="string">449091-762400</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8204-5701</idno>
              <idno type="IDREF">https://www.idref.fr/077039378</idno>
              <idno type="VIAF">https://viaf.org/viaf/197852192</idno>
              <idno type="ISNI">http://isni.org/isni/0000000431446988</idno>
              <affiliation ref="#struct-1196526"/>
              <affiliation ref="#struct-300157"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Peyrin‐Biroulet</surname>
              </persName>
              <email type="md5">a6495c80ac2c55e562421bef2b6734cc</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1111110</idno>
              <idno type="halauthorid" notation="string">3219502-1111110</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2536-6618</idno>
              <idno type="IDREF">https://www.idref.fr/087640147</idno>
              <affiliation ref="#struct-409232"/>
              <affiliation ref="#struct-300157"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>David</forename>
                <surname>MOULIN</surname>
              </persName>
              <email type="md5">3e4dd93a12f5e452d2286ca2e92961fb</email>
              <email type="domain">univ-lorraine.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-11-24 10:27:02</date>
              <date type="whenModified">2026-05-06 12:12:26</date>
              <date type="whenReleased">2025-11-24 11:26:24</date>
              <date type="whenProduced">2025-10</date>
              <date type="whenEndEmbargoed">2025-11-24</date>
              <ref type="file" target="https://hal.science/hal-05379217v1/document">
                <date notBefore="2025-11-24"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-05379217v1/file/BONSOI-D-25-00207_R1%20-%20copie.pdf" id="file-5379217-4602680">
                <date notBefore="2025-11-24"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="83813">
                <persName>
                  <forename>David</forename>
                  <surname>MOULIN</surname>
                </persName>
                <email type="md5">3e4dd93a12f5e452d2286ca2e92961fb</email>
                <email type="domain">univ-lorraine.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05379217</idno>
            <idno type="halUri">https://hal.science/hal-05379217</idno>
            <idno type="halBibtex">morizot:hal-05379217</idno>
            <idno type="halRefHtml">&lt;i&gt;Joint Bone Spine&lt;/i&gt;, 2025, 92 (5), pp.105922. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.jbspin.2025.105922"&gt;&amp;#x27E8;10.1016/j.jbspin.2025.105922&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Joint Bone Spine, 2025, 92 (5), pp.105922. &amp;#x27E8;10.1016/j.jbspin.2025.105922&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-5379217-4602680"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="IMOPA-UL">IMoPA - Ingénierie Moléculaire, Cellulaire et Physiopathologie</idno>
            <idno type="stamp" n="NGERE-UL">NGERE - Nutrition-génétique et exposition aux risques environnementaux</idno>
            <idno type="stamp" n="BMS-UL">Pôle scientifique Biologie, Médecine, Santé de l'Université de Lorraine</idno>
            <idno type="stamp" n="IMOPA-REMPACOAT">Équipe Médecine Régénérative Pharmacologie &amp; Caractérisation des tissus ostéoarticulaires</idno>
            <idno type="stamp" n="IMOPA-CIMIND">Équipe Cell-engineering and Immunomodulation of Inflammatory and Neoplastic Disorders</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Advanced combination therapy in inflammatory bowel disease</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Morizot</surname>
                  </persName>
                  <email type="md5">63747db0878f6b1480f5192dea691902</email>
                  <email type="domain">chru-nancy.fr</email>
                  <idno type="idhal" notation="string">caroline-morizot</idno>
                  <idno type="idhal" notation="numeric">1443789</idno>
                  <idno type="halauthorid" notation="string">2000284-1443789</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3512-2409</idno>
                  <affiliation ref="#struct-300157"/>
                  <affiliation ref="#struct-1196526"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Léa</forename>
                    <surname>Sequier</surname>
                  </persName>
                  <idno type="halauthorid">3445871-0</idno>
                  <affiliation ref="#struct-493422"/>
                  <affiliation ref="#struct-303483"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Yves</forename>
                    <surname>Jouzeau</surname>
                  </persName>
                  <email type="md5">0306723518f8b174c97de4dda18ef8fd</email>
                  <email type="domain">univ-lorraine.fr</email>
                  <idno type="idhal" notation="string">jean-yves-jouzeau</idno>
                  <idno type="idhal" notation="numeric">17914</idno>
                  <idno type="halauthorid" notation="string">10369-17914</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2429-945X</idno>
                  <idno type="IDREF">https://www.idref.fr/070287376</idno>
                  <affiliation ref="#struct-1196526"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Moulin</surname>
                  </persName>
                  <email type="md5">3e4dd93a12f5e452d2286ca2e92961fb</email>
                  <email type="domain">univ-lorraine.fr</email>
                  <idno type="idhal" notation="string">david-moulin</idno>
                  <idno type="idhal" notation="numeric">17909</idno>
                  <idno type="halauthorid" notation="string">33670-17909</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/J-3849-2014</idno>
                  <idno type="IDREF">https://www.idref.fr/096283408</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6619-5769</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/J-3849-2014</idno>
                  <affiliation ref="#struct-1196526"/>
                  <affiliation ref="#struct-300157"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <surname>Netter</surname>
                  </persName>
                  <email type="md5">85401f29482533893fe4bf75b6000a98</email>
                  <email type="domain">yahoo.fr</email>
                  <idno type="idhal" notation="numeric">853560</idno>
                  <idno type="halauthorid" notation="string">170617-853560</idno>
                  <idno type="IDREF">https://www.idref.fr/060277688</idno>
                  <affiliation ref="#struct-1196526"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bénédicte</forename>
                    <surname>Caron</surname>
                  </persName>
                  <idno type="halauthorid">2268319-0</idno>
                  <affiliation ref="#struct-409232"/>
                  <affiliation ref="#struct-300157"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sailish</forename>
                    <surname>Honap</surname>
                  </persName>
                  <idno type="halauthorid">3445872-0</idno>
                  <affiliation ref="#struct-1227244"/>
                  <affiliation ref="#struct-327716"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Damien</forename>
                    <surname>Loeuille</surname>
                  </persName>
                  <email type="md5">1eaad1aa6281e3a2320697b3db1c222e</email>
                  <email type="domain">chu-nancy.fr</email>
                  <idno type="idhal" notation="numeric">762400</idno>
                  <idno type="halauthorid" notation="string">449091-762400</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8204-5701</idno>
                  <idno type="IDREF">https://www.idref.fr/077039378</idno>
                  <idno type="VIAF">https://viaf.org/viaf/197852192</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000431446988</idno>
                  <affiliation ref="#struct-1196526"/>
                  <affiliation ref="#struct-300157"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Peyrin‐Biroulet</surname>
                  </persName>
                  <email type="md5">a6495c80ac2c55e562421bef2b6734cc</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1111110</idno>
                  <idno type="halauthorid" notation="string">3219502-1111110</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2536-6618</idno>
                  <idno type="IDREF">https://www.idref.fr/087640147</idno>
                  <affiliation ref="#struct-409232"/>
                  <affiliation ref="#struct-300157"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">14977</idno>
                <idno type="issn">1297-319X</idno>
                <title level="j">Joint Bone Spine</title>
                <imprint>
                  <publisher>Elsevier Masson</publisher>
                  <biblScope unit="volume">92</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">105922</biblScope>
                  <date type="datePub">2025-10</date>
                  <date type="dateEpub">2025-05-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.jbspin.2025.105922</idno>
              <idno type="pubmed">40414524</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Advanced Combination Therapy</term>
                <term xml:lang="en">Inflammatory Bowel Disease</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: The advent of advanced therapies in the recent years have improved outcomes for inflammatory bowel disease patients, but a significant subset of patients remains refractory to monotherapy. Advanced combination therapy, involving two biologic agents or a biologic combined with a small molecule drug, is emerging as a potential strategy to improve clinical remission and address extra-intestinal manifestations.Methods: This narrative review summarizes current evidence on advanced combination therapy for inflammatory bowel disease, including mechanisms of action, clinical efficacy, safety considerations, and future perspectives. Key clinical trials and real-world studies were analyzed to assess advanced combination therapy outcomes.Results: Preliminary data indicate that advanced combination therapy enhances response rates in patients who fail monotherapy and appears to be a new therapeutic option in patients with refractory disease or extra-intestinal manifestations. However, long-term safety concerns remain, and few clinicals trials have investigated advanced combination therapy, and standardized guidelines regarding its use in clinical practice are lacking.Conclusions: Advanced combination therapy represents a promising yet evolving approach in inflammatory bowel disease management. Future research should focus on optimizing combination strategies, identifying patient subgroups most likely to benefit, and establishing safety profiles through large-scale controlled trials. The integration of precision medicine approaches, including biomarker-driven treatment selection, will be crucial in maximizing the efficacy of advanced combination therapy in clinical practice.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-300157" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Nancy</orgName>
          <orgName type="acronym">CHRU Nancy</orgName>
          <desc>
            <address>
              <addrLine>Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXHôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 NancyHôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-NancyMaternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1196526" status="VALID">
          <idno type="IdRef">180727281</idno>
          <idno type="ISNI">0000000417589034</idno>
          <idno type="RNSR">201320578R</idno>
          <idno type="IdUnivLorraine">[UL]RNG--</idno>
          <idno type="ROR">https://ror.org/04yc2e502</idno>
          <orgName>Ingénierie Moléculaire, Cellulaire et Physiopathologie</orgName>
          <orgName type="acronym">IMOPA</orgName>
          <date type="start">2024-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lorraine, Faculté de Médicine, 9 avenue de la Forêt de Haye, BP 184, 54505 Vandoeuvre-les-Nancy Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.imopa.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-413289" type="direct"/>
            <relation name="UMR7365" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-493422" status="VALID">
          <orgName>Hôpital Universitaire Carémeau [Nîmes]</orgName>
          <orgName type="acronym">CHU Nîmes</orgName>
          <desc>
            <address>
              <addrLine>Place du Professeur Robert Debré, 30900 Nîmes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nimes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-361498" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303483" status="VALID">
          <idno type="ROR">https://ror.org/04pwyfk22</idno>
          <orgName>Hôpital Saint Eloi [CHU Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>80 avenue Augustin Fliche - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/a-propos-du-chu/decouvrir/etablissements/saint-eloi</ref>
          </desc>
          <listRelation>
            <relation active="#struct-258773" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-409232" status="VALID">
          <idno type="IdRef">172251281</idno>
          <idno type="ISNI">000000040383051X</idno>
          <idno type="RNSR">200919208U</idno>
          <idno type="IdUnivLorraine">[UL]RNJ--</idno>
          <idno type="ROR">https://ror.org/053d03003</idno>
          <orgName>Nutrition-Génétique et Exposition aux Risques Environnementaux</orgName>
          <orgName type="acronym">NGERE</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lorraine, Faculté de Médecine, 9 avenue de la Forêt de Haye, 54500 Vandoeuvre-les-Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ngere.univ-lorraine.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMRS954/UMRS1256" active="#struct-303623" type="direct"/>
            <relation active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1227244" status="VALID">
          <idno type="ROR">https://ror.org/039zedc16</idno>
          <orgName>St George’s University Hospitals NHS Foundation Trust [London]</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
            <ref type="url">https://www.stgeorges.nhs.uk/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-327716" status="VALID">
          <orgName>King‘s College London</orgName>
          <desc>
            <address>
              <addrLine>Strand Campus, London WC2R 2LS</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.kcl.ac.uk</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-413289" status="VALID">
          <idno type="IdRef">157040569</idno>
          <idno type="IdUnivLorraine">[UL]100--</idno>
          <idno type="ROR">https://ror.org/04vfs2w97</idno>
          <orgName>Université de Lorraine</orgName>
          <orgName type="acronym">UL</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lorraine.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-361498" status="VALID">
          <idno type="ROR">https://ror.org/0275ye937</idno>
          <orgName>Centre Hospitalier Universitaire de Nîmes</orgName>
          <orgName type="acronym">CHU Nîmes</orgName>
          <desc>
            <address>
              <addrLine>4 Rue du Professeur Robert Debré, 30029 Nîmes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nimes.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-258773" status="VALID">
          <idno type="ISNI">000000009961060X</idno>
          <idno type="ROR">https://ror.org/04m6sq715</idno>
          <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
          <orgName type="acronym">CHRU Montpellier</orgName>
          <desc>
            <address>
              <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>