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            <title xml:lang="en">Testing circuit-level theories of consciousness in humans</title>
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                <title xml:lang="en">Testing circuit-level theories of consciousness in humans</title>
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                <term xml:lang="en">apical amplification theory</term>
                <term xml:lang="en">biophysical modeling</term>
                <term xml:lang="en">consciousness</term>
                <term xml:lang="en">dendritic integration theory</term>
                <term xml:lang="en">neuroimaging</term>
                <term xml:lang="en">pyramidal neurons</term>
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              <p>Our understanding of the neural basis of consciousness is mostly restricted to large-scale brain activity patterns as measured by methods such as functional magnetic resonance imaging (fMRI) and magneto/electro-encephalography (M/EEG). In contrast, we lack even basic understanding of circuit-level mechanisms supporting consciousness - particularly in humans - despite the fundamental role that such mechanisms likely play in instantiating larger-scale brain activity patterns supporting conscious states and contents. Here, we review what progress has been made on circuit-level theories of consciousness (e.g., apical amplification theory, dendritic integration theory) and argue that such theories can be tested in humans using recently developed, state-of-the-art methods. Doing so will further facilitate translation of consciousness science into clinical settings and strengthen the bridge between circuit- and network-level theories of consciousness.</p>
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