<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05320946</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-14T00:04:27+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Effects of Chlorella Supplementation in the Prevention of Iron Deficiency Anemia: A Review of Clinical and Experimental Studies</title>
            <author role="aut">
              <persName>
                <forename type="first">Maria Laura Da</forename>
                <surname>Silva</surname>
              </persName>
              <idno type="halauthorid">3838012-0</idno>
              <affiliation ref="#struct-1610389"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elton Santos Guedes De</forename>
                <surname>Morais</surname>
              </persName>
              <idno type="halauthorid">3467220-0</idno>
              <affiliation ref="#struct-1610389"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Newton Antas</forename>
                <surname>Pereira</surname>
              </persName>
              <idno type="halauthorid">3838013-0</idno>
              <affiliation ref="#struct-1610389"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cíntia</forename>
                <surname>Chaves</surname>
              </persName>
              <idno type="halauthorid">3838014-0</idno>
              <affiliation ref="#struct-1610389"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pedro Henrique</forename>
                <surname>Imazaki</surname>
              </persName>
              <email type="md5">77af742fbc946a541a3bf2fd66d85597</email>
              <email type="domain">envt.fr</email>
              <idno type="idhal" notation="string">phimazaki</idno>
              <idno type="idhal" notation="numeric">1496017</idno>
              <idno type="halauthorid" notation="string">3108518-1496017</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=BA4upTcAAAAJ</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1993-0350</idno>
              <affiliation ref="#struct-1002437"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clarissa</forename>
                <surname>Detomi de Albuquerque</surname>
              </persName>
              <email type="md5">56541c920bcd46bcad08435ad8bad105</email>
              <email type="domain">supagro.fr</email>
              <idno type="idhal" notation="string">clarissa-detomi</idno>
              <idno type="idhal" notation="numeric">1146844</idno>
              <idno type="halauthorid" notation="string">1684952-1146844</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4807-700X</idno>
              <affiliation ref="#struct-1100827"/>
              <affiliation ref="#struct-1096330"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elizabeth Sampaio De</forename>
                <surname>Medeiros</surname>
              </persName>
              <idno type="halauthorid">3424552-0</idno>
              <affiliation ref="#struct-1225117"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anísio Francisco</forename>
                <surname>Soares</surname>
              </persName>
              <idno type="halauthorid">2745104-0</idno>
              <affiliation ref="#struct-1225117"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Link</forename>
                <surname>Stream</surname>
              </persName>
              <email type="md5">083612a0fbd99c46d5d07f73ea8bb3fc</email>
              <email type="domain">outlook.com</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-10-18 11:33:00</date>
              <date type="whenModified">2026-03-18 14:22:02</date>
              <date type="whenReleased">2025-10-18 11:33:00</date>
              <date type="whenProduced">2025-10-17</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1715257">
                <persName>
                  <forename>Link</forename>
                  <surname>Stream</surname>
                </persName>
                <email type="md5">083612a0fbd99c46d5d07f73ea8bb3fc</email>
                <email type="domain">outlook.com</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05320946</idno>
            <idno type="halUri">https://hal.science/hal-05320946</idno>
            <idno type="halBibtex">silva:hal-05320946</idno>
            <idno type="halRefHtml">&lt;i&gt;Archives of Current Research International&lt;/i&gt;, 2025, 25 (10), pp.250-260</idno>
            <idno type="halRef">Archives of Current Research International, 2025, 25 (10), pp.250-260</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="SHS">Sciences de l'Homme et de la Société</idno>
            <idno type="stamp" n="IATE">Ingénierie des agropolymères et technologies émergentes</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="SABP">Sciences pour les Agro Bio Procédés</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="INSTITUT-AGRO-MONTPELLIER">Institut Agro Montpellier</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="INRAEOCCITANIEMONTPELLIER" corresp="INRAE">INRAE Occitanie Montpellier</idno>
            <idno type="stamp" n="INRAEOCCITANIETOULOUSE" corresp="INRAE">INRAE Occitanie Toulouse</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="UM-EPE" corresp="UNIV-MONTPELLIER">Université de Montpellier - EPE</idno>
            <idno type="stamp" n="RESEAU-EAU">Réseau "Systèmes Agricoles et Eau"</idno>
            <idno type="stamp" n="INSTITUT-AGRO">Institut Agro</idno>
            <idno type="stamp" n="PUBLIS-EC-IA-MTP" corresp="PUBLIS-EC-IA">Publications des enseignants chercheurs de l'Institut Agro Montpellier</idno>
            <idno type="stamp" n="PUBLIS-EC-IA">Publications des enseignants chercheurs de l'Institut Agro</idno>
            <idno type="stamp" n="ENVT">École Nationale Vétérinaire de Toulouse </idno>
            <idno type="stamp" n="INTHERES" corresp="INRAE">Innovations Thérapeutiques et Résistances</idno>
            <idno type="stamp" n="DPT-SANTE-ANIMALE">Département Santé Animale</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Effects of Chlorella Supplementation in the Prevention of Iron Deficiency Anemia: A Review of Clinical and Experimental Studies</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Maria Laura Da</forename>
                    <surname>Silva</surname>
                  </persName>
                  <idno type="halauthorid">3838012-0</idno>
                  <affiliation ref="#struct-1610389"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elton Santos Guedes De</forename>
                    <surname>Morais</surname>
                  </persName>
                  <idno type="halauthorid">3467220-0</idno>
                  <affiliation ref="#struct-1610389"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Newton Antas</forename>
                    <surname>Pereira</surname>
                  </persName>
                  <idno type="halauthorid">3838013-0</idno>
                  <affiliation ref="#struct-1610389"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cíntia</forename>
                    <surname>Chaves</surname>
                  </persName>
                  <idno type="halauthorid">3838014-0</idno>
                  <affiliation ref="#struct-1610389"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pedro Henrique</forename>
                    <surname>Imazaki</surname>
                  </persName>
                  <email type="md5">77af742fbc946a541a3bf2fd66d85597</email>
                  <email type="domain">envt.fr</email>
                  <idno type="idhal" notation="string">phimazaki</idno>
                  <idno type="idhal" notation="numeric">1496017</idno>
                  <idno type="halauthorid" notation="string">3108518-1496017</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=BA4upTcAAAAJ</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1993-0350</idno>
                  <affiliation ref="#struct-1002437"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clarissa</forename>
                    <surname>Detomi de Albuquerque</surname>
                  </persName>
                  <email type="md5">56541c920bcd46bcad08435ad8bad105</email>
                  <email type="domain">supagro.fr</email>
                  <idno type="idhal" notation="string">clarissa-detomi</idno>
                  <idno type="idhal" notation="numeric">1146844</idno>
                  <idno type="halauthorid" notation="string">1684952-1146844</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4807-700X</idno>
                  <affiliation ref="#struct-1100827"/>
                  <affiliation ref="#struct-1096330"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elizabeth Sampaio De</forename>
                    <surname>Medeiros</surname>
                  </persName>
                  <idno type="halauthorid">3424552-0</idno>
                  <affiliation ref="#struct-1225117"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anísio Francisco</forename>
                    <surname>Soares</surname>
                  </persName>
                  <idno type="halauthorid">2745104-0</idno>
                  <affiliation ref="#struct-1225117"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">175643</idno>
                <idno type="issn">2454-7077</idno>
                <title level="j">Archives of Current Research International</title>
                <imprint>
                  <publisher>Sciencedomain International</publisher>
                  <biblScope unit="volume">25</biblScope>
                  <biblScope unit="issue">10</biblScope>
                  <biblScope unit="pp">250-260</biblScope>
                  <date type="datePub">2025-10-17</date>
                </imprint>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="shs">Humanities and Social Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Aims: This review aimed to evaluate the potential of Chlorella supplementation as a natural alternative for the prevention and treatment of iron-deficiency anemia, emphasizing its nutritional profile, bioactive compounds, and effects on hematological parameters. Study Design: Systematic and descriptive-analytical review of clinical and experimental studies. Place and Duration of Study: Studies published between 2014 and 2024, conducted in different regions, were included without geographical restriction. Methodology: A total of 70 scientific articles were initially identified. After applying eligibility criteria and assessing methodological quality, 36 studies were selected for analysis. The review was conducted in PubMed, Web of Science, and Scopus databases using controlled descriptors and Boolean operators, such as ("nutritional profile" OR "nutritional composition") AND ("Chlorella vulgaris" OR "Chlorella spp"); ("Anemia" AND "Chlorella microalgae"); ("Iron Supplementation"); and ("proteins" OR "lipids" OR "carbohydrates" OR "amino acids" OR "antioxidants" OR "bioactive compounds"). Results: Evidence suggests that Chlorella supplementation may improve hematological parameters, particularly hemoglobin levels, due to its high iron bioavailability and additional nutrients such as vitamins, minerals, and antioxidants. Compared with conventional therapies, Chlorella was generally associated with better tolerability and fewer adverse effects, potentially improving adherence. However, the absence of large-scale, long-term trials and limited direct comparisons with pharmaceutical iron restrict the generalization of current findings. Conclusion: Chlorella represents a promising complementary approach for the management of mild to moderate iron-deficiency anemia. Further multicenter and long-term clinical trials are required to confirm its efficacy, safety, and cost-effectiveness, as well as to define its potential role in standard therapeutic protocols.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-1610389" status="INCOMING">
          <orgName>UFRPE, Recife-PE, Brazil.</orgName>
          <desc>
            <address>
              <country key="BR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1002437" status="VALID">
          <idno type="IdRef">260988758</idno>
          <idno type="ISNI">0000000477775656</idno>
          <idno type="RNSR">201822822H</idno>
          <idno type="ROR">https://ror.org/01shz5j60</idno>
          <orgName>Innovations Thérapeutiques et Résistances</orgName>
          <orgName type="acronym">InTheRes</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>23 chemin des Capelles31076 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.envt.fr/menu-og-32/intheres?destination=node/786</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR 1436" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1100827" status="VALID">
          <idno type="ISNI">0000000403736662</idno>
          <idno type="RNSR">200317667V</idno>
          <idno type="ROR">https://ror.org/0000n5x09</idno>
          <orgName>Ingénierie des Agro-polymères et Technologies Émergentes</orgName>
          <orgName type="acronym">UMR IATE</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Campus de la Gaillarde 2, place Pierre Viala 34 060 Montpellier Cédex 02 - FRANCE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://umr-iate.cirad.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR1208" active="#struct-577435" type="direct"/>
            <relation active="#struct-1096330" type="direct"/>
            <relation active="#struct-1042499" type="indirect"/>
            <relation active="#struct-1100589" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1096330" status="VALID">
          <idno type="IdRef">261038990</idno>
          <idno type="ROR">https://ror.org/03rnk6m14</idno>
          <orgName>Institut Agro Montpellier</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>2, place Viala - Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institut-agro-montpellier.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042499" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1225117" status="VALID">
          <orgName>Universidade Federal Rural de Pernambuco</orgName>
          <orgName type="acronym">UFRPE</orgName>
          <desc>
            <address>
              <addrLine>Recife</addrLine>
              <country key="BR"/>
            </address>
            <ref type="url">https://portal.ufrpe.br/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-300421" status="VALID">
          <idno type="ROR">https://ror.org/03m3gzv89</idno>
          <orgName>École nationale vétérinaire de Toulouse</orgName>
          <orgName type="acronym">ENVT</orgName>
          <desc>
            <address>
              <addrLine>23 chemin des Capelles - 31076 Toulouse Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://envt.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042499" status="VALID">
          <idno type="IdRef">260373249</idno>
          <idno type="ROR">https://ror.org/01dkyve95</idno>
          <orgName>Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement</orgName>
          <orgName type="acronym">Institut Agro</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institut-agro.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1100589" status="VALID">
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>