Article Dans Une Revue Evolution, Medicine, and Public Health Année : 2025

Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology

Walker Mellon
Beckett Sterner
  • Fonction : Auteur
J. Arvid Ågren
  • Fonction : Auteur
Matthew Marx
  • Fonction : Auteur
Stefania Kapsetaki
Ping-Han Huang
  • Fonction : Auteur
Bryan Yavari
  • Fonction : Auteur
Hunter Mccollum
  • Fonction : Auteur
Barbara Natterson-Horowitz
Hannah Human
  • Fonction : Auteur
Cristina Baciu
  • Fonction : Auteur
Harley Richker
  • Fonction : Auteur
Diego Mallo
Carlo Maley
Luke Harmon
  • Fonction : Auteur
Zachary Compton
  • Fonction : Auteur

Résumé

Abstract Comparative phylogenetics provides a wealth of computational tools to understand evolutionary processes and their outcomes. Advances in these methodologies have occurred in parallel with a surge in cross-species genomic and phenotypic data. To date, however, the majority of published studies have focused on classical questions in evolutionary biology, such as speciation and the ecological drivers of trait evolution. Here, we argue that evolutionary medicine in general, and our understanding of the origin and diversification of disease traits in particular, would be greatly expanded by a wider integration of phylogenetic comparative methods (PCMs). We use comparative oncology – the study of cancer across the tree of life – as a case study to demonstrate the power of the approach and show that implementing PCMs can highlight the mode and tempo of the evolutionary changes in intrinsic, species-level disease vulnerabilities.

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Dates et versions

hal-05314560 , version 1 (14-10-2025)

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Citer

Walker Mellon, Beckett Sterner, J. Arvid Ågren, Orsolya Vincze, Matthew Marx, et al.. Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology. Evolution, Medicine, and Public Health, 2025, ⟨10.1093/emph/eoaf039⟩. ⟨hal-05314560⟩
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