<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05303143v2</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-08T01:57:18+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Objective assessment of cardiac function using patient-specific biophysical modeling based on cardiovascular MRI combined with catheterization</title>
            <author role="aut">
              <persName>
                <forename type="first">Maria</forename>
                <surname>Gusseva</surname>
              </persName>
              <idno type="idhal" notation="numeric">1591913</idno>
              <idno type="halauthorid" notation="string">2263021-1591913</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9024-7829</idno>
              <affiliation ref="#struct-545073"/>
              <affiliation ref="#struct-214668"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daniel</forename>
                <forename type="middle">Alexander</forename>
                <surname>Castellanos</surname>
              </persName>
              <email type="md5">701d85d784c1fe6020ab95e742cce1ae</email>
              <email type="domain">cardio.chboston.org</email>
              <idno type="idhal" notation="numeric">1096714</idno>
              <idno type="halauthorid" notation="string">2193283-1096714</idno>
              <affiliation ref="#struct-575907"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Surendranath</forename>
                <surname>Veeram Reddy</surname>
              </persName>
              <idno type="halauthorid">3817000-0</idno>
              <affiliation ref="#struct-545073"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tarique</forename>
                <surname>Hussain</surname>
              </persName>
              <idno type="halauthorid">1159419-0</idno>
              <affiliation ref="#struct-545073"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dominique</forename>
                <surname>Chapelle</surname>
              </persName>
              <email type="md5">ab14cd547c7112c780f4ad96a6a90253</email>
              <email type="domain">inria.fr</email>
              <idno type="idhal" notation="string">dominique-chapelle</idno>
              <idno type="idhal" notation="numeric">7549</idno>
              <idno type="halauthorid" notation="string">30574-7549</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0794-412X</idno>
              <idno type="IDREF">https://www.idref.fr/035018402</idno>
              <affiliation ref="#struct-214668"/>
              <affiliation ref="#struct-1543359"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Radomír</forename>
                <surname>Chabiniok</surname>
              </persName>
              <idno type="idhal" notation="numeric">1591914</idno>
              <idno type="halauthorid" notation="string">2662075-1591914</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7527-2751</idno>
              <affiliation ref="#struct-545073"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Dominique</forename>
                <surname>Chapelle</surname>
              </persName>
              <email type="md5">ab14cd547c7112c780f4ad96a6a90253</email>
              <email type="domain">inria.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1">
              <date type="whenSubmitted">2025-10-08 09:34:28</date>
            </edition>
            <edition n="v2" type="current">
              <date type="whenSubmitted">2026-01-08 14:48:35</date>
              <date type="whenModified">2026-04-08 14:22:10</date>
              <date type="whenReleased">2026-01-15 16:12:19</date>
              <date type="whenProduced">2025</date>
              <date type="whenEndEmbargoed">2026-01-08</date>
              <ref type="file" target="https://hal.science/hal-05303143v2/document">
                <date notBefore="2026-01-08"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-05303143v2/file/gusseva-et-al-2025-objective-assessment-of-cardiac-function-using-patient-specific-biophysical-modeling-based-on-2.pdf" id="file-5448794-4667356">
                <date notBefore="2026-01-08"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="107534">
                <persName>
                  <forename>Dominique</forename>
                  <surname>Chapelle</surname>
                </persName>
                <email type="md5">ab14cd547c7112c780f4ad96a6a90253</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05303143</idno>
            <idno type="halUri">https://hal.science/hal-05303143</idno>
            <idno type="halBibtex">gusseva:hal-05303143</idno>
            <idno type="halRefHtml">&lt;i&gt;AJP - Heart and Circulatory Physiology&lt;/i&gt;, 2025, 329 (5), pp.H118-H1191. &lt;a target="_blank" href="https://dx.doi.org/10.1152/ajpheart.00232.2025"&gt;&amp;#x27E8;10.1152/ajpheart.00232.2025&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">AJP - Heart and Circulatory Physiology, 2025, 329 (5), pp.H118-H1191. &amp;#x27E8;10.1152/ajpheart.00232.2025&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-5448794-4667356"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="X">École polytechnique</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="INRIA-SACLAY" corresp="INRIA">INRIA Saclay - Ile de France</idno>
            <idno type="stamp" n="INSMI">CNRS-INSMI - INstitut des Sciences Mathématiques et de leurs Interactions</idno>
            <idno type="stamp" n="X-CMAP" corresp="X">Centre de Mathématiques Appliquées (CMAP)</idno>
            <idno type="stamp" n="X-LMS" corresp="X">Laboratoire de Mécanique des Solides (LMS)</idno>
            <idno type="stamp" n="X-DEP-MATHA">Département de mathématiques appliquées de l’École polytechnique</idno>
            <idno type="stamp" n="X-DEP-MECA">Département de mécanique de l’École polytechnique </idno>
            <idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="TESTALAIN1">TESTALAIN1</idno>
            <idno type="stamp" n="CMAP">Centre de Mathématiques Appliquées (CMAP)</idno>
            <idno type="stamp" n="INRIA2">INRIA 2</idno>
            <idno type="stamp" n="IP_PARIS">Institut Polytechnique de Paris</idno>
            <idno type="stamp" n="GS-COMPUTER-SCIENCE">Graduate School Computer Science</idno>
            <idno type="stamp" n="INRIA-ETATSUNIS">Copublications Inria-Etats-Unis</idno>
            <idno type="stamp" n="IP-PARIS-DEPARTEMENT-MATHEMATIQUES">Département de Mathèmatiques</idno>
            <idno type="stamp" n="IP-PARIS-MATHEMATIQUES">IP Paris Département de Mathématiques</idno>
            <idno type="stamp" n="IP-PARIS-SCIENCE-ET-INGENIERIE-MECANIQUES">IP Paris Département de Science et Ingénierie Mécaniques</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Objective assessment of cardiac function using patient-specific biophysical modeling based on cardiovascular MRI combined with catheterization</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Maria</forename>
                    <surname>Gusseva</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1591913</idno>
                  <idno type="halauthorid" notation="string">2263021-1591913</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9024-7829</idno>
                  <affiliation ref="#struct-545073"/>
                  <affiliation ref="#struct-214668"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daniel</forename>
                    <forename type="middle">Alexander</forename>
                    <surname>Castellanos</surname>
                  </persName>
                  <email type="md5">701d85d784c1fe6020ab95e742cce1ae</email>
                  <email type="domain">cardio.chboston.org</email>
                  <idno type="idhal" notation="numeric">1096714</idno>
                  <idno type="halauthorid" notation="string">2193283-1096714</idno>
                  <affiliation ref="#struct-575907"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Surendranath</forename>
                    <surname>Veeram Reddy</surname>
                  </persName>
                  <idno type="halauthorid">3817000-0</idno>
                  <affiliation ref="#struct-545073"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tarique</forename>
                    <surname>Hussain</surname>
                  </persName>
                  <idno type="halauthorid">1159419-0</idno>
                  <affiliation ref="#struct-545073"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dominique</forename>
                    <surname>Chapelle</surname>
                  </persName>
                  <email type="md5">ab14cd547c7112c780f4ad96a6a90253</email>
                  <email type="domain">inria.fr</email>
                  <idno type="idhal" notation="string">dominique-chapelle</idno>
                  <idno type="idhal" notation="numeric">7549</idno>
                  <idno type="halauthorid" notation="string">30574-7549</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0794-412X</idno>
                  <idno type="IDREF">https://www.idref.fr/035018402</idno>
                  <affiliation ref="#struct-214668"/>
                  <affiliation ref="#struct-1543359"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Radomír</forename>
                    <surname>Chabiniok</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1591914</idno>
                  <idno type="halauthorid" notation="string">2662075-1591914</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7527-2751</idno>
                  <affiliation ref="#struct-545073"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">10309</idno>
                <idno type="issn">0363-6135</idno>
                <idno type="eissn">1522-1539</idno>
                <title level="j">AJP - Heart and Circulatory Physiology</title>
                <imprint>
                  <publisher>American Physiological Society</publisher>
                  <biblScope unit="volume">329</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">H118-H1191</biblScope>
                  <date type="datePub">2025</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1152/ajpheart.00232.2025</idno>
              <idno type="pubmed">41015406</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">myocardial contractility</term>
                <term xml:lang="en">time-varying elastance</term>
                <term xml:lang="en">cardiovascular physiology</term>
                <term xml:lang="en">clinical data processing</term>
                <term xml:lang="en">biomechanical modeling</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="halDomain" n="spi.meca">Engineering Sciences [physics]/Mechanics [physics.med-ph]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Synthesizing multi-modality data, such as cardiovascular magnetic resonance imaging (MRI) combined with catheterization, into a single framework is challenging. Different acquisition systems are subjected to different measurement errors. Coupling clinical data with biomechanical models can assist in clinical data processing (e.g., model-based filtering of measurement noise) and quantify myocardial mechanics via metrics not readily available in the data, such as myocardial contractility. In this work we use a biomechanical modeling with the aim 1) to quantitatively compare model- and data-derived signals, and 2) to explore the potential of model-derived myocardial contractility and distal resistance of the circulation (Rd) to robustly quantify cardiovascular physiology. We used 51 ventricular catheterization pressure and cine MRI volume datasets from patients with single-ventricle physiology and left and right ventricles of patients with repaired tetralogy of Fallot. Ventricular time-varying elastance (TVE) metrics and linear regression were used to quantify the relationship between the maximum value of TVE (Emax) and maximum time derivative of ventricular pressure (max(dP/dt)) in data- and model-derived pressure and volume signals at p&amp;lt;0.05. Pearson’s correlations were used to compare model-derived contractility and data-derived Emax and max(dP/dt), and model-derived Rd and data-derived vascular resistance. All data and model-derived linear regressions were significant (p&amp;lt;0.05). Model-derived max(dP/dt) vs. data-derived Emax produced higher R2 than data-derived max(dP/dt) vs. data-derived Emax. Correlations demonstrated significant relationships between most data- and model-derived metrics. This work revealed the clinical value of biomechanical modeling to assist in clinical data processing by providing high-quality pressure and volume signals, and to quantify cardiovascular pathophysiology.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-545073" status="VALID">
          <idno type="ISNI">0000 0000 9482 7121</idno>
          <idno type="ROR">https://ror.org/05byvp690</idno>
          <orgName>University of Texas Southwestern Medical Center</orgName>
          <desc>
            <address>
              <addrLine>5323 Harry Hines Blvd., Dallas, Texas, TX 75390</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.utsouthwestern.edu/</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-214668" status="VALID">
          <idno type="RNSR">201321220N</idno>
          <idno type="ROR">https://ror.org/05xtj5718</idno>
          <orgName>Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine</orgName>
          <orgName type="acronym">M3DISIM</orgName>
          <date type="start">2013-01-01</date>
          <date type="end">2025-08-31</date>
          <desc>
            <address>
              <addrLine>Bât. Alan Turing ; Campus de l'Ecole Polytechnique ; 1 rue Honoré d'Estienne d'Orves, 91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/equipes/m3disim</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1167" type="direct"/>
            <relation active="#struct-300340" type="indirect"/>
            <relation active="#struct-563936" type="indirect"/>
            <relation name="UMR7649" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1225635" type="direct"/>
            <relation active="#struct-118511" type="indirect"/>
            <relation active="#struct-300009" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-575907" status="VALID">
          <orgName>Boston Children's Hospital</orgName>
          <desc>
            <address>
              <addrLine>300 Longwood Avenue,Boston, MA 02115</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">http://www.childrenshospital.org/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-130467" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1543359" status="VALID">
          <idno type="RNSR">202524721S</idno>
          <orgName>Analyse et Calcul d’Estimations fondées sur des connaissances physiques</orgName>
          <orgName type="acronym">ANANKE</orgName>
          <date type="start">2025-09-01</date>
          <date type="end">2028-10-31</date>
          <desc>
            <address>
              <addrLine>1 rue Honoré d'Estienne d'Orves Bâtiment Alan Turing Campus de l'École Polytechnique 91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-89626" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
            <relation active="#struct-300340" type="indirect"/>
            <relation active="#struct-563936" type="indirect"/>
            <relation name="UMR7641" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1225635" type="direct"/>
            <relation active="#struct-118511" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1167" status="VALID">
          <idno type="IdRef">077600649</idno>
          <idno type="ISNI">0000000122879755</idno>
          <idno type="RNSR">199719346W</idno>
          <idno type="ROR">https://ror.org/00xd1ek73</idno>
          <idno type="Wikidata">Q30262303</idno>
          <orgName>Laboratoire de Mécanique des Solides</orgName>
          <orgName type="acronym">LMS</orgName>
          <date type="start">1997-01-01</date>
          <desc>
            <address>
              <addrLine>Route de Saclay, 91128 Palaiseau Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://lms.ip-paris.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300340" type="direct"/>
            <relation active="#struct-563936" type="indirect"/>
            <relation name="UMR7649" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300340" status="VALID">
          <idno type="IdRef">027309320</idno>
          <idno type="ISNI">0000000121581279</idno>
          <idno type="ROR">https://ror.org/05hy3tk52</idno>
          <idno type="Wikidata">Q273626</idno>
          <orgName>École polytechnique</orgName>
          <orgName type="acronym">X</orgName>
          <date type="start">1794-03-11</date>
          <desc>
            <address>
              <addrLine>Route de Saclay, 91128 Palaiseau Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.polytechnique.edu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-563936" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-563936" status="VALID">
          <idno type="IdRef">238327159</idno>
          <idno type="ISNI">0000000502717600</idno>
          <idno type="ROR">https://ror.org/042tfbd02</idno>
          <idno type="Wikidata">Q48759778</idno>
          <orgName>Institut Polytechnique de Paris</orgName>
          <orgName type="acronym">IP Paris</orgName>
          <date type="start">2019-06-02</date>
          <desc>
            <address>
              <addrLine>Route de Saclay, 91120 Palaiseau Cedex, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ip-paris.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-1225635" status="VALID">
          <idno type="ROR">https://ror.org/026839t73</idno>
          <orgName>Centre Inria de l'Institut Polytechnique de Paris</orgName>
          <date type="start">2022-11-01</date>
          <desc>
            <address>
              <addrLine>1 rue Honoré d'Estienne d'Orves –Bâtiment Alan Turing –Campus de l'École Polytechnique –91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-118511" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-118511" status="VALID">
          <idno type="RNSR">200818248E</idno>
          <idno type="ROR">https://ror.org/0315e5x55</idno>
          <orgName>Centre Inria de Saclay</orgName>
          <desc>
            <address>
              <addrLine>1 rue Honoré d'Estienne d'OrvesBâtiment Alan TuringCampus de l'École Polytechnique91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/centre/saclay</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300009" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300009" status="VALID">
          <idno type="ROR">https://ror.org/02kvxyf05</idno>
          <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
          <orgName type="acronym">Inria</orgName>
          <desc>
            <address>
              <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/en/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-130467" status="VALID">
          <idno type="ROR">https://ror.org/03wevmz92</idno>
          <orgName>Harvard Medical School [Boston]</orgName>
          <orgName type="acronym">HMS</orgName>
          <desc>
            <address>
              <addrLine>25 Shattuck Street Boston, MA 02115</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">http://www.hms.harvard.edu</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-89626" status="VALID">
          <idno type="IdRef">197373461</idno>
          <idno type="ISNI">000000010944436X</idno>
          <idno type="RNSR">199719340P</idno>
          <idno type="ROR">https://ror.org/012e1xn46</idno>
          <idno type="Wikidata">Q16008922</idno>
          <orgName>Centre de Mathématiques Appliquées de l'Ecole polytechnique</orgName>
          <orgName type="acronym">CMAP</orgName>
          <date type="start">2005-01-01</date>
          <desc>
            <address>
              <addrLine>Route de Saclay, 91128 Palaiseau Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://cmap.ip-paris.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300009" type="direct"/>
            <relation active="#struct-300340" type="direct"/>
            <relation active="#struct-563936" type="indirect"/>
            <relation name="UMR7641" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>