<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05296617</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-12T18:04:55+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Pathology-oriented multiplexing enables integrative disease mapping</title>
            <author role="co_first_author">
              <persName>
                <forename type="first">Malte</forename>
                <surname>Kuehl</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590159</idno>
              <idno type="halauthorid" notation="string">3808792-1590159</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4167-2498</idno>
            </author>
            <author role="co_first_author">
              <persName>
                <forename type="first">Yusuke</forename>
                <surname>Okabayashi</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590160</idno>
              <idno type="halauthorid" notation="string">3808793-1590160</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7150-6947</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Milagros</forename>
                <surname>Wong</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590161</idno>
              <idno type="halauthorid" notation="string">3808794-1590161</idno>
              <idno type="ORCID">https://orcid.org/0009-0008-6372-7094</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lukas</forename>
                <surname>Gernhold</surname>
              </persName>
              <idno type="halauthorid">3808795-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gabriele</forename>
                <surname>Gut</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590162</idno>
              <idno type="halauthorid" notation="string">3808796-1590162</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8991-0040</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nico</forename>
                <surname>Kaiser</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590163</idno>
              <idno type="halauthorid" notation="string">2115414-1590163</idno>
              <idno type="ORCID">https://orcid.org/0009-0006-6054-2831</idno>
              <affiliation ref="#struct-300723"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Maria</forename>
                <surname>Schwerk</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590164</idno>
              <idno type="halauthorid" notation="string">3808797-1590164</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1185-2343</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stefanie</forename>
                <surname>Gräfe</surname>
              </persName>
              <idno type="halauthorid">816522-0</idno>
              <affiliation ref="#struct-323073"/>
              <affiliation ref="#struct-463785"/>
              <affiliation ref="#struct-30151"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frank</forename>
                <surname>Ma</surname>
              </persName>
              <idno type="halauthorid">3808798-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jovan</forename>
                <surname>Tanevski</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590165</idno>
              <idno type="halauthorid" notation="string">3808799-1590165</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7177-1003</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philipp</forename>
                <surname>Schäfer</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590166</idno>
              <idno type="halauthorid" notation="string">3808800-1590166</idno>
              <idno type="ORCID">https://orcid.org/0009-0008-4403-8592</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sam</forename>
                <surname>Mezher</surname>
              </persName>
              <idno type="halauthorid">3808801-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jacobo</forename>
                <surname>Sarabia del Castillo</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590167</idno>
              <idno type="halauthorid" notation="string">3808802-1590167</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9656-1416</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thiago</forename>
                <surname>Goldbeck-Strieder</surname>
              </persName>
              <idno type="halauthorid">3808803-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olga</forename>
                <surname>Zolotareva</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590168</idno>
              <idno type="halauthorid" notation="string">3808804-1590168</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9424-8052</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Hartung</surname>
              </persName>
              <idno type="idhal" notation="numeric">1263703</idno>
              <idno type="halauthorid" notation="string">2841958-1263703</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3992-0125</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fernando</forename>
                <surname>Delgado Chaves</surname>
              </persName>
              <idno type="halauthorid">3808805-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lukas</forename>
                <surname>Klinkert</surname>
              </persName>
              <idno type="halauthorid">3808806-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ann-Christin</forename>
                <surname>Gnirck</surname>
              </persName>
              <idno type="halauthorid">3808807-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Spehr</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590169</idno>
              <idno type="halauthorid" notation="string">3808808-1590169</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6616-4196</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Fleck</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590170</idno>
              <idno type="halauthorid" notation="string">3808809-1590170</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6692-2388</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mehdi</forename>
                <surname>Joodaki</surname>
              </persName>
              <idno type="halauthorid">3808810-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Victor</forename>
                <surname>Parra</surname>
              </persName>
              <idno type="halauthorid">3808811-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mina</forename>
                <surname>Shaigan</surname>
              </persName>
              <idno type="halauthorid">3386934-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Martin</forename>
                <surname>Diebold</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590171</idno>
              <idno type="halauthorid" notation="string">3808812-1590171</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9636-6936</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marco</forename>
                <surname>Prinz</surname>
              </persName>
              <idno type="idhal" notation="numeric">1391674</idno>
              <idno type="halauthorid" notation="string">1150573-1391674</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0349-1955</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jennifer</forename>
                <surname>Kranz</surname>
              </persName>
              <idno type="halauthorid">3524390-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Johan</forename>
                <surname>Kux</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590172</idno>
              <idno type="halauthorid" notation="string">3808813-1590172</idno>
              <idno type="ORCID">https://orcid.org/0009-0000-3734-2520</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabian</forename>
                <surname>Braun</surname>
              </persName>
              <idno type="halauthorid">1725934-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Oliver</forename>
                <surname>Kretz</surname>
              </persName>
              <idno type="halauthorid">1739789-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hui</forename>
                <surname>Wu</surname>
              </persName>
              <idno type="halauthorid">1156359-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florian</forename>
                <surname>Grahammer</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590173</idno>
              <idno type="halauthorid" notation="string">2624971-1590173</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7851-754X</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sven</forename>
                <surname>Heins</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590174</idno>
              <idno type="halauthorid" notation="string">3808814-1590174</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4696-672X</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marina</forename>
                <surname>Zimmermann</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590175</idno>
              <idno type="halauthorid" notation="string">3808815-1590175</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2666-5997</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabian</forename>
                <surname>Haas</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590176</idno>
              <idno type="halauthorid" notation="string">1343863-1590176</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5440-1035</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dominik</forename>
                <surname>Kylies</surname>
              </persName>
              <idno type="halauthorid">3808816-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicola</forename>
                <surname>Wanner</surname>
              </persName>
              <idno type="halauthorid">1725935-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jan</forename>
                <surname>Czogalla</surname>
              </persName>
              <idno type="halauthorid">3808817-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bernhard</forename>
                <surname>Dumoulin</surname>
              </persName>
              <idno type="halauthorid">3808818-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nikolay</forename>
                <surname>Zolotarev</surname>
              </persName>
              <idno type="halauthorid">3808819-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Maja</forename>
                <surname>Lindenmeyer</surname>
              </persName>
              <idno type="halauthorid">683362-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pall</forename>
                <surname>Karlson</surname>
              </persName>
              <idno type="halauthorid">3808820-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jens</forename>
                <surname>Nyengaard</surname>
              </persName>
              <idno type="halauthorid">2321196-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marcial</forename>
                <surname>Sebode</surname>
              </persName>
              <idno type="halauthorid">2935617-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sören</forename>
                <surname>Weidemann</surname>
              </persName>
              <idno type="halauthorid">3042887-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thorsten</forename>
                <surname>Wiech</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590177</idno>
              <idno type="halauthorid" notation="string">3808821-1590177</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4053-1474</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hermann-Josef</forename>
                <surname>Groene</surname>
              </persName>
              <idno type="halauthorid">3808822-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicola</forename>
                <surname>Tomas</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590178</idno>
              <idno type="halauthorid" notation="string">2936656-1590178</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6385-9862</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Meyer-Schwesinger</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590179</idno>
              <idno type="halauthorid" notation="string">1567498-1590179</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1511-5188</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christoph</forename>
                <surname>Kuppe</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590180</idno>
              <idno type="halauthorid" notation="string">2311004-1590180</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4597-9833</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rafael</forename>
                <surname>Kramann</surname>
              </persName>
              <idno type="halauthorid">3421522-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexandre</forename>
                <surname>Karras</surname>
              </persName>
              <idno type="idhal" notation="numeric">762481</idno>
              <idno type="halauthorid" notation="string">452304-762481</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3075-7739</idno>
              <idno type="IDREF">https://www.idref.fr/077765036</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <surname>Bruneval</surname>
              </persName>
              <idno type="idhal" notation="numeric">756352</idno>
              <idno type="halauthorid" notation="string">137153-756352</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2350-2914</idno>
              <affiliation ref="#struct-1004693"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Louis</forename>
                <surname>Tharaux</surname>
              </persName>
              <email type="md5">dcd81ce3c2483766e65eb958012e6334</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">pierre-louis-tharaux</idno>
              <idno type="idhal" notation="numeric">1063993</idno>
              <idno type="halauthorid" notation="string">139290-1063993</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6062-5905</idno>
              <idno type="IDREF">https://www.idref.fr/035728906</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/A-9155-2009</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-9155-2009</idno>
              <affiliation ref="#struct-1004693"/>
              <affiliation ref="#struct-1042190"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Diego</forename>
                <surname>Pastene</surname>
              </persName>
              <idno type="halauthorid">3808823-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benito</forename>
                <surname>Yard</surname>
              </persName>
              <idno type="halauthorid">2989742-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jennifer</forename>
                <surname>Schaub</surname>
              </persName>
              <idno type="halauthorid">3808824-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Phillip</forename>
                <surname>Mccown</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590181</idno>
              <idno type="halauthorid" notation="string">3808825-1590181</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8012-1931</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laura</forename>
                <surname>Pyle</surname>
              </persName>
              <idno type="halauthorid">3808826-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ye Ji</forename>
                <surname>Choi</surname>
              </persName>
              <idno type="halauthorid">3808827-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Takashi</forename>
                <surname>Yokoo</surname>
              </persName>
              <idno type="halauthorid">3808828-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jan</forename>
                <surname>Baumbach</surname>
              </persName>
              <idno type="idhal" notation="numeric">1263700</idno>
              <idno type="halauthorid" notation="string">951997-1263700</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0282-0462</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pablo</forename>
                <surname>Sáez</surname>
              </persName>
              <idno type="idhal" notation="numeric">1409118</idno>
              <idno type="halauthorid" notation="string">2099220-1409118</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0521-9426</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ivan</forename>
                <surname>Costa</surname>
              </persName>
              <idno type="idhal" notation="numeric">1546023</idno>
              <idno type="halauthorid" notation="string">820235-1546023</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2890-8697</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jan-Eric</forename>
                <surname>Turner</surname>
              </persName>
              <idno type="idhal" notation="numeric">1590182</idno>
              <idno type="halauthorid" notation="string">3808829-1590182</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1677-5455</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jeffrey</forename>
                <surname>Hodgin</surname>
              </persName>
              <idno type="halauthorid">3808830-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julio</forename>
                <surname>Saez-Rodriguez</surname>
              </persName>
              <idno type="halauthorid">663201-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tobias</forename>
                <surname>Huber</surname>
              </persName>
              <idno type="idhal" notation="numeric">807137</idno>
              <idno type="halauthorid" notation="string">1677818-807137</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7175-5062</idno>
            </author>
            <author role="co_last_author">
              <persName>
                <forename type="first">Petter</forename>
                <surname>Bjornstad</surname>
              </persName>
              <idno type="halauthorid">3808831-0</idno>
            </author>
            <author role="co_last_author">
              <persName>
                <forename type="first">Matthias</forename>
                <surname>Kretzler</surname>
              </persName>
              <idno type="idhal" notation="numeric">1210126</idno>
              <idno type="halauthorid" notation="string">477443-1210126</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4064-0582</idno>
            </author>
            <author role="co_last_author">
              <persName>
                <forename type="first">Olivia</forename>
                <surname>Lenoir</surname>
              </persName>
              <email type="md5">48ed5481b7a930ce7333752332487b8b</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">olivia-lenoir</idno>
              <idno type="idhal" notation="numeric">740840</idno>
              <idno type="halauthorid" notation="string">35693-740840</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAY-2493-2020</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8107-6987</idno>
              <idno type="IDREF">https://www.idref.fr/159482429</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAY-2493-2020</idno>
              <affiliation ref="#struct-1004693"/>
            </author>
            <author role="co_last_author">
              <persName>
                <forename type="first">David</forename>
                <surname>Nikolic-Paterson</surname>
              </persName>
              <idno type="halauthorid">1577315-0</idno>
            </author>
            <author role="co_last_author">
              <persName>
                <forename type="first">Lucas</forename>
                <surname>Pelkmans</surname>
              </persName>
              <idno type="halauthorid">880139-0</idno>
            </author>
            <author role="co_last_author">
              <persName>
                <forename type="first">Stefan</forename>
                <surname>Bonn</surname>
              </persName>
              <idno type="idhal" notation="numeric">1418592</idno>
              <idno type="halauthorid" notation="string">1700736-1418592</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4366-5662</idno>
            </author>
            <author role="co_last_author">
              <persName>
                <forename type="first">Victor</forename>
                <surname>Puelles</surname>
              </persName>
              <email type="md5">1a426c691cc5d2fbcc1e49de041f6020</email>
              <email type="domain">uke.de</email>
              <idno type="idhal" notation="numeric">1179718</idno>
              <idno type="halauthorid" notation="string">1747923-1179718</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7735-5462</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Pierre-Louis</forename>
                <surname>Tharaux</surname>
              </persName>
              <email type="md5">dcd81ce3c2483766e65eb958012e6334</email>
              <email type="domain">inserm.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2026-02-11 15:14:15</date>
              <date type="whenModified">2026-03-10 15:49:54</date>
              <date type="whenReleased">2026-03-05 11:00:24</date>
              <date type="whenProduced">2025-08-14</date>
              <date type="whenEndEmbargoed">2026-02-11</date>
              <ref type="file" target="https://hal.science/hal-05296617v1/document">
                <date notBefore="2026-02-11"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-05296617v1/file/41586_2025_Article_9225.pdf" id="file-5475998-4741172">
                <date notBefore="2026-02-11"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350167"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="49529">
                <persName>
                  <forename>Pierre-Louis</forename>
                  <surname>Tharaux</surname>
                </persName>
                <email type="md5">dcd81ce3c2483766e65eb958012e6334</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05296617</idno>
            <idno type="halUri">https://hal.science/hal-05296617</idno>
            <idno type="halBibtex">kuehl:hal-05296617</idno>
            <idno type="halRefHtml">&lt;i&gt;Nature&lt;/i&gt;, 2025, 644 (8076), pp.516-526. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41586-025-09225-2"&gt;&amp;#x27E8;10.1038/s41586-025-09225-2&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nature, 2025, 644 (8076), pp.516-526. &amp;#x27E8;10.1038/s41586-025-09225-2&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-5475998-4741172"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Pathology-oriented multiplexing enables integrative disease mapping</title>
                <author role="co_first_author">
                  <persName>
                    <forename type="first">Malte</forename>
                    <surname>Kuehl</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590159</idno>
                  <idno type="halauthorid" notation="string">3808792-1590159</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4167-2498</idno>
                </author>
                <author role="co_first_author">
                  <persName>
                    <forename type="first">Yusuke</forename>
                    <surname>Okabayashi</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590160</idno>
                  <idno type="halauthorid" notation="string">3808793-1590160</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7150-6947</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Milagros</forename>
                    <surname>Wong</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590161</idno>
                  <idno type="halauthorid" notation="string">3808794-1590161</idno>
                  <idno type="ORCID">https://orcid.org/0009-0008-6372-7094</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lukas</forename>
                    <surname>Gernhold</surname>
                  </persName>
                  <idno type="halauthorid">3808795-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gabriele</forename>
                    <surname>Gut</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590162</idno>
                  <idno type="halauthorid" notation="string">3808796-1590162</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8991-0040</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nico</forename>
                    <surname>Kaiser</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590163</idno>
                  <idno type="halauthorid" notation="string">2115414-1590163</idno>
                  <idno type="ORCID">https://orcid.org/0009-0006-6054-2831</idno>
                  <affiliation ref="#struct-300723"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Maria</forename>
                    <surname>Schwerk</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590164</idno>
                  <idno type="halauthorid" notation="string">3808797-1590164</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1185-2343</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stefanie</forename>
                    <surname>Gräfe</surname>
                  </persName>
                  <idno type="halauthorid">816522-0</idno>
                  <affiliation ref="#struct-323073"/>
                  <affiliation ref="#struct-463785"/>
                  <affiliation ref="#struct-30151"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frank</forename>
                    <surname>Ma</surname>
                  </persName>
                  <idno type="halauthorid">3808798-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jovan</forename>
                    <surname>Tanevski</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590165</idno>
                  <idno type="halauthorid" notation="string">3808799-1590165</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7177-1003</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philipp</forename>
                    <surname>Schäfer</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590166</idno>
                  <idno type="halauthorid" notation="string">3808800-1590166</idno>
                  <idno type="ORCID">https://orcid.org/0009-0008-4403-8592</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sam</forename>
                    <surname>Mezher</surname>
                  </persName>
                  <idno type="halauthorid">3808801-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jacobo</forename>
                    <surname>Sarabia del Castillo</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590167</idno>
                  <idno type="halauthorid" notation="string">3808802-1590167</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9656-1416</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thiago</forename>
                    <surname>Goldbeck-Strieder</surname>
                  </persName>
                  <idno type="halauthorid">3808803-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olga</forename>
                    <surname>Zolotareva</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590168</idno>
                  <idno type="halauthorid" notation="string">3808804-1590168</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9424-8052</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Hartung</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1263703</idno>
                  <idno type="halauthorid" notation="string">2841958-1263703</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3992-0125</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fernando</forename>
                    <surname>Delgado Chaves</surname>
                  </persName>
                  <idno type="halauthorid">3808805-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lukas</forename>
                    <surname>Klinkert</surname>
                  </persName>
                  <idno type="halauthorid">3808806-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ann-Christin</forename>
                    <surname>Gnirck</surname>
                  </persName>
                  <idno type="halauthorid">3808807-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Spehr</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590169</idno>
                  <idno type="halauthorid" notation="string">3808808-1590169</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6616-4196</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Fleck</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590170</idno>
                  <idno type="halauthorid" notation="string">3808809-1590170</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6692-2388</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mehdi</forename>
                    <surname>Joodaki</surname>
                  </persName>
                  <idno type="halauthorid">3808810-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Victor</forename>
                    <surname>Parra</surname>
                  </persName>
                  <idno type="halauthorid">3808811-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mina</forename>
                    <surname>Shaigan</surname>
                  </persName>
                  <idno type="halauthorid">3386934-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Martin</forename>
                    <surname>Diebold</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590171</idno>
                  <idno type="halauthorid" notation="string">3808812-1590171</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9636-6936</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marco</forename>
                    <surname>Prinz</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1391674</idno>
                  <idno type="halauthorid" notation="string">1150573-1391674</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0349-1955</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jennifer</forename>
                    <surname>Kranz</surname>
                  </persName>
                  <idno type="halauthorid">3524390-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Johan</forename>
                    <surname>Kux</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590172</idno>
                  <idno type="halauthorid" notation="string">3808813-1590172</idno>
                  <idno type="ORCID">https://orcid.org/0009-0000-3734-2520</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabian</forename>
                    <surname>Braun</surname>
                  </persName>
                  <idno type="halauthorid">1725934-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Oliver</forename>
                    <surname>Kretz</surname>
                  </persName>
                  <idno type="halauthorid">1739789-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hui</forename>
                    <surname>Wu</surname>
                  </persName>
                  <idno type="halauthorid">1156359-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florian</forename>
                    <surname>Grahammer</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590173</idno>
                  <idno type="halauthorid" notation="string">2624971-1590173</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7851-754X</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sven</forename>
                    <surname>Heins</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590174</idno>
                  <idno type="halauthorid" notation="string">3808814-1590174</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4696-672X</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marina</forename>
                    <surname>Zimmermann</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590175</idno>
                  <idno type="halauthorid" notation="string">3808815-1590175</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2666-5997</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabian</forename>
                    <surname>Haas</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590176</idno>
                  <idno type="halauthorid" notation="string">1343863-1590176</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5440-1035</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dominik</forename>
                    <surname>Kylies</surname>
                  </persName>
                  <idno type="halauthorid">3808816-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicola</forename>
                    <surname>Wanner</surname>
                  </persName>
                  <idno type="halauthorid">1725935-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jan</forename>
                    <surname>Czogalla</surname>
                  </persName>
                  <idno type="halauthorid">3808817-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bernhard</forename>
                    <surname>Dumoulin</surname>
                  </persName>
                  <idno type="halauthorid">3808818-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nikolay</forename>
                    <surname>Zolotarev</surname>
                  </persName>
                  <idno type="halauthorid">3808819-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Maja</forename>
                    <surname>Lindenmeyer</surname>
                  </persName>
                  <idno type="halauthorid">683362-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pall</forename>
                    <surname>Karlson</surname>
                  </persName>
                  <idno type="halauthorid">3808820-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jens</forename>
                    <surname>Nyengaard</surname>
                  </persName>
                  <idno type="halauthorid">2321196-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marcial</forename>
                    <surname>Sebode</surname>
                  </persName>
                  <idno type="halauthorid">2935617-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sören</forename>
                    <surname>Weidemann</surname>
                  </persName>
                  <idno type="halauthorid">3042887-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thorsten</forename>
                    <surname>Wiech</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590177</idno>
                  <idno type="halauthorid" notation="string">3808821-1590177</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4053-1474</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hermann-Josef</forename>
                    <surname>Groene</surname>
                  </persName>
                  <idno type="halauthorid">3808822-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicola</forename>
                    <surname>Tomas</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590178</idno>
                  <idno type="halauthorid" notation="string">2936656-1590178</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6385-9862</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Meyer-Schwesinger</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590179</idno>
                  <idno type="halauthorid" notation="string">1567498-1590179</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1511-5188</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christoph</forename>
                    <surname>Kuppe</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590180</idno>
                  <idno type="halauthorid" notation="string">2311004-1590180</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4597-9833</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rafael</forename>
                    <surname>Kramann</surname>
                  </persName>
                  <idno type="halauthorid">3421522-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexandre</forename>
                    <surname>Karras</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">762481</idno>
                  <idno type="halauthorid" notation="string">452304-762481</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3075-7739</idno>
                  <idno type="IDREF">https://www.idref.fr/077765036</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <surname>Bruneval</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">756352</idno>
                  <idno type="halauthorid" notation="string">137153-756352</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2350-2914</idno>
                  <affiliation ref="#struct-1004693"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Louis</forename>
                    <surname>Tharaux</surname>
                  </persName>
                  <email type="md5">dcd81ce3c2483766e65eb958012e6334</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">pierre-louis-tharaux</idno>
                  <idno type="idhal" notation="numeric">1063993</idno>
                  <idno type="halauthorid" notation="string">139290-1063993</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6062-5905</idno>
                  <idno type="IDREF">https://www.idref.fr/035728906</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/A-9155-2009</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-9155-2009</idno>
                  <affiliation ref="#struct-1004693"/>
                  <affiliation ref="#struct-1042190"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Diego</forename>
                    <surname>Pastene</surname>
                  </persName>
                  <idno type="halauthorid">3808823-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benito</forename>
                    <surname>Yard</surname>
                  </persName>
                  <idno type="halauthorid">2989742-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jennifer</forename>
                    <surname>Schaub</surname>
                  </persName>
                  <idno type="halauthorid">3808824-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Phillip</forename>
                    <surname>Mccown</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590181</idno>
                  <idno type="halauthorid" notation="string">3808825-1590181</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8012-1931</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laura</forename>
                    <surname>Pyle</surname>
                  </persName>
                  <idno type="halauthorid">3808826-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ye Ji</forename>
                    <surname>Choi</surname>
                  </persName>
                  <idno type="halauthorid">3808827-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Takashi</forename>
                    <surname>Yokoo</surname>
                  </persName>
                  <idno type="halauthorid">3808828-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jan</forename>
                    <surname>Baumbach</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1263700</idno>
                  <idno type="halauthorid" notation="string">951997-1263700</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0282-0462</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pablo</forename>
                    <surname>Sáez</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1409118</idno>
                  <idno type="halauthorid" notation="string">2099220-1409118</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0521-9426</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ivan</forename>
                    <surname>Costa</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1546023</idno>
                  <idno type="halauthorid" notation="string">820235-1546023</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2890-8697</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jan-Eric</forename>
                    <surname>Turner</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1590182</idno>
                  <idno type="halauthorid" notation="string">3808829-1590182</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1677-5455</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jeffrey</forename>
                    <surname>Hodgin</surname>
                  </persName>
                  <idno type="halauthorid">3808830-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julio</forename>
                    <surname>Saez-Rodriguez</surname>
                  </persName>
                  <idno type="halauthorid">663201-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tobias</forename>
                    <surname>Huber</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">807137</idno>
                  <idno type="halauthorid" notation="string">1677818-807137</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7175-5062</idno>
                </author>
                <author role="co_last_author">
                  <persName>
                    <forename type="first">Petter</forename>
                    <surname>Bjornstad</surname>
                  </persName>
                  <idno type="halauthorid">3808831-0</idno>
                </author>
                <author role="co_last_author">
                  <persName>
                    <forename type="first">Matthias</forename>
                    <surname>Kretzler</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1210126</idno>
                  <idno type="halauthorid" notation="string">477443-1210126</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4064-0582</idno>
                </author>
                <author role="co_last_author">
                  <persName>
                    <forename type="first">Olivia</forename>
                    <surname>Lenoir</surname>
                  </persName>
                  <email type="md5">48ed5481b7a930ce7333752332487b8b</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">olivia-lenoir</idno>
                  <idno type="idhal" notation="numeric">740840</idno>
                  <idno type="halauthorid" notation="string">35693-740840</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAY-2493-2020</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8107-6987</idno>
                  <idno type="IDREF">https://www.idref.fr/159482429</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAY-2493-2020</idno>
                  <affiliation ref="#struct-1004693"/>
                </author>
                <author role="co_last_author">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Nikolic-Paterson</surname>
                  </persName>
                  <idno type="halauthorid">1577315-0</idno>
                </author>
                <author role="co_last_author">
                  <persName>
                    <forename type="first">Lucas</forename>
                    <surname>Pelkmans</surname>
                  </persName>
                  <idno type="halauthorid">880139-0</idno>
                </author>
                <author role="co_last_author">
                  <persName>
                    <forename type="first">Stefan</forename>
                    <surname>Bonn</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1418592</idno>
                  <idno type="halauthorid" notation="string">1700736-1418592</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4366-5662</idno>
                </author>
                <author role="co_last_author">
                  <persName>
                    <forename type="first">Victor</forename>
                    <surname>Puelles</surname>
                  </persName>
                  <email type="md5">1a426c691cc5d2fbcc1e49de041f6020</email>
                  <email type="domain">uke.de</email>
                  <idno type="idhal" notation="numeric">1179718</idno>
                  <idno type="halauthorid" notation="string">1747923-1179718</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7735-5462</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">7333</idno>
                <idno type="issn">0028-0836</idno>
                <idno type="eissn">1476-4687</idno>
                <title level="j">Nature</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">644</biblScope>
                  <biblScope unit="issue">8076</biblScope>
                  <biblScope unit="pp">516-526</biblScope>
                  <date type="datePub">2025-08-14</date>
                  <date type="dateEpub">2025-07-18</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41586-025-09225-2</idno>
              <idno type="pubmed">40681898</idno>
              <idno type="pubmedcentral">PMC12350167</idno>
              <ref type="publisher">https://www.nature.com/articles/s41586-025-09225-2</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The expression and location of proteins in tissues represent key determinants of health and disease. Although recent advances in multiplexed imaging have expanded the number of spatially accessible proteins 1–3 , the integration of biological layers (that is, cell structure, subcellular domains and signalling activity) remains challenging. This is due to limitations in the compositions of antibody panels and image resolution, which together restrict the scope of image analysis. Here we present pathology-oriented multiplexing (PathoPlex), a scalable, quality-controlled and interpretable framework. It combines highly multiplexed imaging at subcellular resolution with a software package to extract and interpret protein co-expression patterns (clusters) across biological layers. PathoPlex was optimized to map more than 140 commercial antibodies at 80 nm per pixel across 95 iterative imaging cycles and provides pragmatic solutions to enable the simultaneous processing of at least 40 archival biopsy specimens. In a proof-of-concept experiment, we identified epithelial JUN activity as a key switch in immune-mediated kidney disease, thereby demonstrating that clusters can capture relevant pathological features. PathoPlex was then used to analyse human diabetic kidney disease. The framework linked patient-level clusters to organ disfunction and identified disease traits with therapeutic potential (that is, calcium-mediated tubular stress). Finally, PathoPlex was used to reveal renal stress-related clusters in individuals with type 2 diabetes without histological kidney disease. Moreover, tissue-based readouts were generated to assess responses to inhibitors of the glucose cotransporter SGLT2. In summary, PathoPlex paves the way towards democratizing multiplexed imaging and establishing integrative image analysis tools in complex tissues to support the development of next-generation pathology atlases.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-300723" status="VALID">
          <orgName>Technische Universität Darmstadt - Technical University of Darmstadt [Darmstadt]</orgName>
          <orgName type="acronym">TU Darmstadt</orgName>
          <desc>
            <address>
              <addrLine>Karolinenplatz 5, 64289 Darmstadt</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.tu-darmstadt.de/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-323073" status="VALID">
          <idno type="ROR">https://ror.org/05mxhda18</idno>
          <orgName>University Hospital of Cologne [Cologne]</orgName>
          <desc>
            <address>
              <addrLine>Cologne</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.uhc-international.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-463785" status="VALID">
          <idno type="ROR">https://ror.org/00rcxh774</idno>
          <orgName>Universität zu Köln = University of Cologne</orgName>
          <date type="start">2016-09-14</date>
          <desc>
            <address>
              <addrLine>Albertus-Magnus-Platz, 50923 Köln</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.uni-koeln.de</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-30151" status="VALID">
          <orgName>Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf  [Hamburg]</orgName>
          <orgName type="acronym">UKE</orgName>
          <date type="start">1889</date>
          <desc>
            <address>
              <addrLine>Martinistraße 5220251 Hamburg</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.uke.de/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1004693" status="VALID">
          <idno type="IdRef">166439185</idno>
          <idno type="ISNI">0000 0004 0495 1460</idno>
          <idno type="RNSR">201019165T</idno>
          <idno type="ROR">https://ror.org/03gvnh520</idno>
          <orgName>Paris-Centre de Recherche Cardiovasculaire</orgName>
          <orgName type="acronym">PARCC (UMR_S 970/ U970)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>56 rue Leblanc75015 PARISFRANCE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://parcc.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U970" active="#struct-300119" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation active="#struct-353414" type="indirect"/>
            <relation name="U970" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 970" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1042190" status="VALID">
          <orgName>UFR Médecine [Santé] - Université Paris Cité</orgName>
          <orgName type="acronym">UFR Médecine UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>15 rue de l’École de Médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/medecine/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300119" status="VALID">
          <idno type="IdRef">052497380</idno>
          <idno type="ROR">https://ror.org/016vx5156</idno>
          <orgName>Hôpital Européen Georges Pompidou [APHP]</orgName>
          <orgName type="acronym">HEGP</orgName>
          <desc>
            <address>
              <addrLine>20, rue Leblanc, 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopital-georgespompidou.aphp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-353414" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-353414" status="VALID">
          <orgName>Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest</orgName>
          <orgName type="acronym">HUPO</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopitaux-parisouest.aphp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>