Rethinking HLA-B27 Testing: What HLA-B27 Can— and Cannot—Tell Us
Résumé
HLA-B27: a cornerstone in spondyloarthritis Nearly 50 years after its discovery as a major genetic risk factor for spondyloarthritis (SpA), 1 the precise contribution of HLA-B27 to disease development and progression remains only partially understood. Proposed mechanisms include aberrant antigen presentation, misfolding-induced endoplasmic reticulum stress and modulation of innate immune responses. 2