Article Dans Une Revue Journal of Rheumatology Année : 2025

Rethinking HLA-B27 Testing: What HLA-B27 Can— and Cannot—Tell Us

Marie Beaufrère
Bilade Cherqaoui

Résumé

HLA-B27: a cornerstone in spondyloarthritis Nearly 50 years after its discovery as a major genetic risk factor for spondyloarthritis (SpA), 1 the precise contribution of HLA-B27 to disease development and progression remains only partially understood. Proposed mechanisms include aberrant antigen presentation, misfolding-induced endoplasmic reticulum stress and modulation of innate immune responses. 2

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Dates et versions

hal-05287194 , version 1 (28-09-2025)

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Citer

Marie Beaufrère, Bilade Cherqaoui, Félicie Costantino. Rethinking HLA-B27 Testing: What HLA-B27 Can— and Cannot—Tell Us. Journal of Rheumatology, 2025, pp.jrheum.2025-0809. ⟨10.3899/jrheum.2025-0809⟩. ⟨hal-05287194⟩
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