<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05285694</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T14:08:23+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">From disorder to icosahedral symmetry: How conformation-switching subunits enable RNA virus assembly</title>
            <author role="aut">
              <persName>
                <forename type="first">Siyu</forename>
                <surname>Li</surname>
              </persName>
              <idno type="idhal" notation="numeric">1587595</idno>
              <idno type="halauthorid" notation="string">1313335-1587595</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4326-7560</idno>
              <affiliation ref="#struct-300446"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guillaume</forename>
                <surname>Tresset</surname>
              </persName>
              <email type="md5">52b78bd5f41c96e85c03ce3bf308779a</email>
              <email type="domain">universite-paris-saclay.fr</email>
              <idno type="idhal" notation="string">guillaume-tresset</idno>
              <idno type="idhal" notation="numeric">741238</idno>
              <idno type="halauthorid" notation="string">118807-741238</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3755-4109</idno>
              <idno type="IDREF">https://www.idref.fr/074276689</idno>
              <affiliation ref="#struct-1199683"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Roya</forename>
                <surname>Zandi</surname>
              </persName>
              <email type="md5">db5f2f859f601c9941438110e3c6deb2</email>
              <email type="domain">ucr.edu</email>
              <idno type="idhal" notation="numeric">1269718</idno>
              <idno type="halauthorid" notation="string">464647-1269718</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8769-0419</idno>
              <affiliation ref="#struct-300446"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Guillaume</forename>
                <surname>Tresset</surname>
              </persName>
              <email type="md5">52b78bd5f41c96e85c03ce3bf308779a</email>
              <email type="domain">universite-paris-saclay.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-09-26 16:33:31</date>
              <date type="whenModified">2025-10-02 03:15:55</date>
              <date type="whenReleased">2025-09-30 16:10:48</date>
              <date type="whenProduced">2025-09-26</date>
              <date type="whenEndEmbargoed">2025-09-26</date>
              <ref type="file" target="https://hal.science/hal-05285694v1/document">
                <date notBefore="2025-09-26"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-05285694v1/file/Li%20et%20al.%20-%202025%20-%20From%20disorder%20to%20icosahedral%20symmetry%20How%20conformation-switching%20subunits%20enable%20RNA%20virus%20assembly.pdf" id="file-5285694-4533150">
                <date notBefore="2025-09-26"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="353571">
                <persName>
                  <forename>Guillaume</forename>
                  <surname>Tresset</surname>
                </persName>
                <email type="md5">52b78bd5f41c96e85c03ce3bf308779a</email>
                <email type="domain">universite-paris-saclay.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05285694</idno>
            <idno type="halUri">https://hal.science/hal-05285694</idno>
            <idno type="halBibtex">li:hal-05285694</idno>
            <idno type="halRefHtml">&lt;i&gt;Science Advances &lt;/i&gt;, 2025, 11 (39), pp.eady7241. &lt;a target="_blank" href="https://dx.doi.org/10.1126/sciadv.ady7241"&gt;&amp;#x27E8;10.1126/sciadv.ady7241&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Science Advances , 2025, 11 (39), pp.eady7241. &amp;#x27E8;10.1126/sciadv.ady7241&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-5285694-4533150"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="GS-CHIMIE">Graduate School Chimie</idno>
            <idno type="stamp" n="GS-PHYSIQUE">Graduate School Physique</idno>
            <idno type="stamp" n="GS-LIFE-SCIENCES-HEALTH" corresp="UNIVERSITE-PARIS-SACLAY">Graduate School Life Sciences and Health</idno>
            <idno type="stamp" n="INSTITUT-SCIENCES-LUMIERE">Institut des Sciences de la Lumière</idno>
            <idno type="stamp" n="LPSO">Laboratoire de Physique des Solides d'Orsay</idno>
            <idno type="stamp" n="URP-LPS">Laboratoire de Psychologie Sociale : contextes et régulation</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">From disorder to icosahedral symmetry: How conformation-switching subunits enable RNA virus assembly</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Siyu</forename>
                    <surname>Li</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1587595</idno>
                  <idno type="halauthorid" notation="string">1313335-1587595</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4326-7560</idno>
                  <affiliation ref="#struct-300446"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Tresset</surname>
                  </persName>
                  <email type="md5">52b78bd5f41c96e85c03ce3bf308779a</email>
                  <email type="domain">universite-paris-saclay.fr</email>
                  <idno type="idhal" notation="string">guillaume-tresset</idno>
                  <idno type="idhal" notation="numeric">741238</idno>
                  <idno type="halauthorid" notation="string">118807-741238</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3755-4109</idno>
                  <idno type="IDREF">https://www.idref.fr/074276689</idno>
                  <affiliation ref="#struct-1199683"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Roya</forename>
                    <surname>Zandi</surname>
                  </persName>
                  <email type="md5">db5f2f859f601c9941438110e3c6deb2</email>
                  <email type="domain">ucr.edu</email>
                  <idno type="idhal" notation="numeric">1269718</idno>
                  <idno type="halauthorid" notation="string">464647-1269718</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8769-0419</idno>
                  <affiliation ref="#struct-300446"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">105430</idno>
                <idno type="issn">2375-2548</idno>
                <title level="j">Science Advances </title>
                <imprint>
                  <publisher>American Association for the Advancement of Science (AAAS)</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <biblScope unit="issue">39</biblScope>
                  <biblScope unit="pp">eady7241</biblScope>
                  <date type="datePub">2025-09-26</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1126/sciadv.ady7241</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="phys.phys.phys-bio-ph">Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bs">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]</classCode>
              <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Icosahedral capsids are ubiquitous among spherical viruses, yet their assembly pathways and governing interactions remain elusive. We present a molecular dynamics model that incorporates essential physical and biological features, including protein diffusion, genome flexibility, and a conformational switch that mimics allostery and activates the elastic properties of proteins upon binding. This switch makes the simulations computationally feasible, overcoming long-standing limitations of previous models. Using this framework, we successfully reproduce the self-assembly of subunits into icosahedral shells with T numbers greater than one-most notably T = 3, the most common structure in nature-a feat rigid-body models have so far failed to achieve. We also examine how genome architecture influences assembly and observe trends consistent with experiments using cowpea chlorotic mottle virus proteins: RNAs with more complex structure yield more complete capsids than do linear ones. These results establish a predictive framework for genome-guided assembly and offer insight into designing synthetic capsids for biomedical applications.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-300446" status="VALID">
          <idno type="ROR">https://ror.org/03nawhv43</idno>
          <orgName>University of California [Riverside]</orgName>
          <orgName type="acronym">UC Riverside</orgName>
          <desc>
            <address>
              <addrLine>900 University Ave. Riverside, CA 92521</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.ucr.edu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-471291" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1199683" status="VALID">
          <orgName>Laboratoire de Physique des Solides - SOBIO</orgName>
          <orgName type="acronym">LPS</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Bat. 510 91405 Orsay cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1051087" type="direct"/>
            <relation active="#struct-419361" type="indirect"/>
            <relation name="UMR8502" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-471291" status="VALID">
          <idno type="ROR">https://ror.org/00pjdza24</idno>
          <orgName>University of California</orgName>
          <orgName type="acronym">UC</orgName>
          <date type="start">1869-01-01</date>
          <desc>
            <address>
              <country key="US"/>
            </address>
            <ref type="url">https://www.universityofcalifornia.edu/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1051087" status="VALID">
          <idno type="IdRef">155036955</idno>
          <idno type="ISNI">0000000094046552</idno>
          <idno type="RNSR">199812838T</idno>
          <idno type="ROR">https://ror.org/02dyaew97</idno>
          <idno type="Wikidata">Q3214477</idno>
          <orgName>Laboratoire de Physique des Solides</orgName>
          <orgName type="acronym">LPS</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Bat. 510 91405 Orsay cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lps.u-psud.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-419361" type="direct"/>
            <relation name="UMR8502" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>