Poster De Conférence Année : 2025

Optimization of phosphorus dendrimer analysis by MALDI-TOF

Résumé

Dendrimers are tree-like macromolecules studied in various fields of application (materials, catalysis, biology...). Because of their good compatibility with living systems, phosphorus-containing dendrimers can be used in biology, particularly as drug carriers. The use of dendrimers as drug carriers can enhance their activity and facilitate targeting and cellular penetration. Various antiinfectious agents were grafted onto the periphery of cyclotriphosphazene-cored phosphorus-containing dendrimers. MALDI ionization is the method of choice for analyzing these high-mass molecules, but the results obtained are highly dependent on the preparation of the deposit, the nature of the matrix used and whether alkali metal salts are added or not to the preparation.

Fichier principal
Vignette du fichier
Journée SFSM 2025 DENDRIMERES.pdf (873.99 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-05225665 , version 1 (27-08-2025)

Licence

Identifiants

  • HAL Id : hal-05225665 , version 1

Citer

Valérie Bourdon, Eric Leroy, Justine Ferey, Valérie Maraval, Charlotte Aparici. Optimization of phosphorus dendrimer analysis by MALDI-TOF. 41es journées françaises de spectrométrie de masse (JFSM), Jun 2025, Montpellier, France. ⟨hal-05225665⟩
197 Consultations
48 Téléchargements

Partager

  • More