Communication Dans Un Congrès Année : 2025

Synthesis of multivalent chondroitin sulfate oligosaccharides targeting the exosites of cathepsin K

Résumé

Chondroitin sulfate (CS) are heteropolysaccharides that belong to a family of complex polyanionic polymers called glycosaminoglycans (GAGs). They consist of a repeating disaccharide unit composed of a D-glucuronic acid (D-GlcA) and 2-acetamindo-2-deoxy-D-galactose (D-GalNAc) and bearing sulfate groups primarily at the position 4 (CS-A) and/or position 6 (CS-E/CS-C) of the D-GalNAc [1]. Their structural diversity and sulfation patterns determine their biological functions, including neuronal development, morphogenesis, and cell-cell recognition, through interactions with various proteins [2]. Additionally, CS are major structural components of connective tissues, particularly in cartilage, skin, and bone [3]. Multivalency is a key feature in glycan-protein interactions, enhancing both affinity and specificity while enabling supramolecular organization at the cell surface [4]. Despite its importance, multivalent CS constructs remain scarce [5]. Here, we present our approach, for the synthesis of well-defined CS oligosaccharides with controlled sulfation [6] patterns and various linkage systems and platforms to promote multivalency.

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Dates et versions

hal-05221849 , version 1 (25-08-2025)

Identifiants

  • HAL Id : hal-05221849 , version 1

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Christopher Herailh, Elodie Treuillet, Pierre Buisson, Régis Daniel, Fabien Lecaille, et al.. Synthesis of multivalent chondroitin sulfate oligosaccharides targeting the exosites of cathepsin K. 22th European Carbohydrate Symposium, Jul 2025, Gdansk, Poland. ⟨hal-05221849⟩
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