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              <p>&lt;div&gt;&lt;p&gt;18 Background: Glycol ethers (GEs) are oxygenated solvents widely found in occupational and consumer 19 water-based products. Some of them are well-known reproductive and developmental toxicants. 20 Objectives: To study the variations in circulating sex steroid hormones, measured in cord blood, 21 according to biomarkers of prenatal GE exposure. 22 Methods: The study population comes from the PELAGIE mother-child cohort, which enrolled 23 pregnant women from Brittany (France, 2002-2006). Maternal urine samples were collected from a 24 random subcohort (n=338) before 19 weeks' gestation, from which we measured 8 alkoxycarboxylic 25 metabolites of GEs. We subsequently measured 13 sex steroid hormones and sex hormone-binding 26 globulin (SHBG) in cord blood samples. Linear regressions adjusted for potential confounders were 27 used, and nonlinear dose-response associations were investigated. 28 Results: The detection rates of GE metabolites ranged from 4% to 98%; only the 5 most detected 29 (&amp;gt;20%) metabolites were investigated further. Phenoxyacetic acid (detection rate &amp;gt;95%) was 30 associated with lower levels of SHBG and various steroids (17-alpha-hydroxy-Pregnenolone, delta-5-31 androstenediol, and dehydroepiandrosterone) among boys and higher SHBG and 16-alpha-hydroxy-32 dehydroepiandrosterone levels among girls. The two other highly detected metabolites, 33 methoxyetoxyacetic acid and butoxyacetic acid, were associated with variations in estradiol. 34 Butoxyacetic acid was associated with higher delta-5-androstenediol levels while detectable levels of 35 methoxyacetic acid were associated with lower levels of this hormone. 36 Conclusion: Our study suggests that prenatal exposure to GE may affect endocrine response 37 patterns, estimated by determining blood levels of sex steroid hormones in newborns. These results 38 raise questions about the potential role of these changes in the pathways between prenatal GE 39 exposure and previously reported adverse developmental outcomes, including impaired 40 neurocognitive performance.&lt;/p&gt;&lt;/div&gt;</p>
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