Pré-Publication, Document De Travail (Preprint/Prepublication) Année : 2025

Brain-blood biomarkers take a walk on the wild side: glial responses to environmental conditions and individual traits in wild frogs

Résumé

We investigated the use of brain Glial fibrillary acidic protein (GFAP), a cytoskeletal protein of astrocytes, that has been associated with brain disorders in clinical studies, as a biomarker of environmental conditions and individual traits in wildlife. In a wild amphibian, plasmatic GFAP-levels were correlated with the salinity of ponds, immune markers and size for males. GFAP-levels were correlated with body condition for both sexes. Interestingly, captivity induced transient increase of plasmatic-GFAP levels, probably due to stress. In our study, we demonstrate that plasmatic-GFAP levels may represent an excellent brain biomarker of its plasticity to environmental conditions, physiological traits, and stress responses in wildlife.

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hal-05196174 , version 1 (01-08-2025)

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Lea Lorrain-Soligon, Christophe J Dubois, Coraline Bichet, Francois Brischoux, Jerome Badaut. Brain-blood biomarkers take a walk on the wild side: glial responses to environmental conditions and individual traits in wild frogs. 2025. ⟨hal-05196174⟩
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