Article Dans Une Revue Chemical Science Année : 2025

Novel lanthanide(III)/gallium(III) metallacrowns with appended visible-absorbing organic sensitizers for molecular near-infrared imaging of living cells

Résumé

Optical imaging of biological samples in the near-infrared (NIR) domain is of major interest for non-invasive experiments due to reduced light scattering, absorption and autofluorescence. Taking advantage of the maleimide moieties in the [Ln2Ga8(shi)8(mip)4]$^{2−}$ metallacrowns (MCs; shi$^{3−}$ = salicylhydroximate; mip$^{2−}$ = 5-maleimido-isophthalate; Ln = NdIII, GdIII, ErIII, YbIII and YIII), we appended visible-absorbing thiol-coumarin (C) sensitizers through a thiol-Michael addition click reaction, affording the functionalized [Ln2Ga8(shi)8(C-mip)4]$^{2−}$ MCs. By using this approach, the sensitization of NIR-emitting NdIII, ErIII and YbIII was achieved upon excitation in the visible range (λ$_{exc}$ = 420 nm) through the appended coumarins. NIR epifluorescence microscopy of living HeLa cells incubated with the NdIII derivative confirmed unambiguous detection of the signal arising from the $^4$F$_{3/2}$ → $^4$I$_{11/2}$ electronic transition in the range of 1050–1080 nm in the cells. These results demonstrate that the [Ln2Ga8(shi)8(mip)4]$^{2−}$ MC can be used as a versatile molecule for tuning the chemical and photophysical properties of the [Ln2Ga8] MC family.

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hal-05176512 , version 1 (22-07-2025)

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Timothée Lathion, Julie Bourseguin, Svetlana V. Eliseeva, Matthias Zeller, Stéphane Petoud, et al.. Novel lanthanide(III)/gallium(III) metallacrowns with appended visible-absorbing organic sensitizers for molecular near-infrared imaging of living cells. Chemical Science, 2025, 16 (27), pp.12623-12634. ⟨10.1039/D5SC01320H⟩. ⟨hal-05176512⟩
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