Graph theory in Disorders of Consciousness: Toward multimodal integration
Résumé
Disorders of consciousness, such as coma, involve disruptions in brain functional connectivity that can be studied using resting-state fMRI. While graph theory helps to map these disruptions, the recovery of consciousness involve mechanisms beyond the BOLD signal. We build on previous work analyzing Translocator Protein (TSPO), a PET marker of neuroinflammation, in coma patients of different etiologies and healthy controls. For the first time, we examined how TSPO relates to fMRI-derived node metrics at the group level. Preliminary results show a relationship in healthy controls that appears disrupted in coma, suggesting that neuroinflamation may impair functional connections in these patients.
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