<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05147938</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T04:03:37+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome</title>
            <author role="aut">
              <persName>
                <forename type="first">Safwen</forename>
                <surname>Ghediri</surname>
              </persName>
              <email type="md5">c95097e236d702ddd0c686aa7eacc553</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="numeric">1559648</idno>
              <idno type="halauthorid" notation="string">3629284-1559648</idno>
              <affiliation ref="#struct-1066983"/>
              <affiliation ref="#struct-1067373"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Parvathy</forename>
                <forename type="middle">A</forename>
                <surname>Sarma</surname>
              </persName>
              <email type="md5">0b3581de5a8c3b6ca6c3771b6e0e065b</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="numeric">1423442</idno>
              <idno type="halauthorid" notation="string">3254791-1423442</idno>
              <affiliation ref="#struct-1066983"/>
              <affiliation ref="#struct-1004619"/>
              <affiliation ref="#struct-425779"/>
              <affiliation ref="#struct-1067373"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vinnarasi</forename>
                <surname>Saravanan</surname>
              </persName>
              <email type="md5">ca1c7a265193726fcc312b294a442902</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1559649</idno>
              <idno type="halauthorid" notation="string">3469881-1559649</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8822-5399</idno>
              <affiliation ref="#struct-1001889"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Corinne</forename>
                <surname>Abbadie</surname>
              </persName>
              <email type="md5">dfdc84c871d2cfefa79a05225956e421</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">corinne-abbadie</idno>
              <idno type="idhal" notation="numeric">1305346</idno>
              <idno type="halauthorid" notation="string">840565-1305346</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8174-2393</idno>
              <idno type="IDREF">https://www.idref.fr/03187309X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-4949-2018</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-4949-2018</idno>
              <affiliation ref="#struct-1004619"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ralf</forename>
                <surname>Blossey</surname>
              </persName>
              <email type="md5">ceeaaa0f19b3f45b2133aa2795190dcd</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">ralf-blossey</idno>
              <idno type="idhal" notation="numeric">1057458</idno>
              <idno type="halauthorid" notation="string">191036-1057458</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4823-7037</idno>
              <affiliation ref="#struct-1001889"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabrizio</forename>
                <surname>Cleri</surname>
              </persName>
              <email type="md5">7c9291bdbfab47d258fc64f816e89993</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">fabrizio-cleri</idno>
              <idno type="idhal" notation="numeric">748019</idno>
              <idno type="halauthorid" notation="string">12942-748019</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0272-7441</idno>
              <idno type="IDREF">https://www.idref.fr/168047853</idno>
              <affiliation ref="#struct-1067373"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Collection</forename>
                <surname>IEMN</surname>
              </persName>
              <email type="md5">f3c4c8abd4ffdc9885dbd6e4ca535087</email>
              <email type="domain">iemn.fr</email>
            </editor>
            <funder ref="#projanr-57046"/>
            <funder ref="#projeurop-714304"/>
            <funder>F.C., R.B., S.G. and V.S. acknowledge funding from the ANR Project “Dyprosome: dynamicsof DNA repair proteins at nucleosomes” ANR-21-CE45-0032. F.C., C.A. and P.A.S. acknowledgefunding from the University of Lille Project PEARL “Senesimex: experiments and modelling ofradiation-induced cell senescence” (H2020 Marie Sklodowska-Curie agreement n. 847568). We thankgenerous computing time allocation on the JEAN-ZAY supercomputer of IDRIS-CNRS in Orsay, andthe ADASTRA supercomputer of CINES in Montpellier, under projects GENCI A0130712986 andA0150712986.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-07-07 11:31:04</date>
              <date type="whenModified">2026-03-23 09:10:02</date>
              <date type="whenReleased">2025-07-07 14:29:40</date>
              <date type="whenProduced">2025-04-30</date>
              <date type="whenEndEmbargoed">2025-07-07</date>
              <ref type="file" target="https://hal.science/hal-05147938v1/document">
                <date notBefore="2025-07-07"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-05147938v1/file/2025_biomolecules-15-00649.pdf" id="file-5147938-4445646">
                <date notBefore="2025-07-07"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="102579">
                <persName>
                  <forename>Collection</forename>
                  <surname>IEMN</surname>
                </persName>
                <email type="md5">f3c4c8abd4ffdc9885dbd6e4ca535087</email>
                <email type="domain">iemn.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05147938</idno>
            <idno type="halUri">https://hal.science/hal-05147938</idno>
            <idno type="halBibtex">ghediri:hal-05147938</idno>
            <idno type="halRefHtml">&lt;i&gt;Biomolecules&lt;/i&gt;, 2025, 15, &lt;a target="_blank" href="https://dx.doi.org/10.3390/biom15050649"&gt;&amp;#x27E8;10.3390/biom15050649&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Biomolecules, 2025, 15, &amp;#x27E8;10.3390/biom15050649&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-5147938-4445646"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-VALENCIENNES">Université de Valenciennes et du Hainaut-Cambresis</idno>
            <idno type="stamp" n="IEMN">Institut d'électronique, de microélectronique et de nanotechnologie</idno>
            <idno type="stamp" n="RIIP_LILLE" corresp="RIIP">Institut Pasteur de Lille</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="GENCI">Publications ayant eu recours aux supercalculateurs du GENCI</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="CANTHER">Cancer heterogeneity, plasticity and resistance to therapies</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UNIV-CATHOLILLE">Université catholique de Lille</idno>
            <idno type="stamp" n="UGSF">Unité de Glycobiologie Structurale et Fonctionnelle</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Safwen</forename>
                    <surname>Ghediri</surname>
                  </persName>
                  <email type="md5">c95097e236d702ddd0c686aa7eacc553</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="numeric">1559648</idno>
                  <idno type="halauthorid" notation="string">3629284-1559648</idno>
                  <affiliation ref="#struct-1066983"/>
                  <affiliation ref="#struct-1067373"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Parvathy</forename>
                    <forename type="middle">A</forename>
                    <surname>Sarma</surname>
                  </persName>
                  <email type="md5">0b3581de5a8c3b6ca6c3771b6e0e065b</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="numeric">1423442</idno>
                  <idno type="halauthorid" notation="string">3254791-1423442</idno>
                  <affiliation ref="#struct-1066983"/>
                  <affiliation ref="#struct-1004619"/>
                  <affiliation ref="#struct-425779"/>
                  <affiliation ref="#struct-1067373"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vinnarasi</forename>
                    <surname>Saravanan</surname>
                  </persName>
                  <email type="md5">ca1c7a265193726fcc312b294a442902</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1559649</idno>
                  <idno type="halauthorid" notation="string">3469881-1559649</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8822-5399</idno>
                  <affiliation ref="#struct-1001889"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Corinne</forename>
                    <surname>Abbadie</surname>
                  </persName>
                  <email type="md5">dfdc84c871d2cfefa79a05225956e421</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">corinne-abbadie</idno>
                  <idno type="idhal" notation="numeric">1305346</idno>
                  <idno type="halauthorid" notation="string">840565-1305346</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8174-2393</idno>
                  <idno type="IDREF">https://www.idref.fr/03187309X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-4949-2018</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-4949-2018</idno>
                  <affiliation ref="#struct-1004619"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ralf</forename>
                    <surname>Blossey</surname>
                  </persName>
                  <email type="md5">ceeaaa0f19b3f45b2133aa2795190dcd</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">ralf-blossey</idno>
                  <idno type="idhal" notation="numeric">1057458</idno>
                  <idno type="halauthorid" notation="string">191036-1057458</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4823-7037</idno>
                  <affiliation ref="#struct-1001889"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabrizio</forename>
                    <surname>Cleri</surname>
                  </persName>
                  <email type="md5">7c9291bdbfab47d258fc64f816e89993</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">fabrizio-cleri</idno>
                  <idno type="idhal" notation="numeric">748019</idno>
                  <idno type="halauthorid" notation="string">12942-748019</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0272-7441</idno>
                  <idno type="IDREF">https://www.idref.fr/168047853</idno>
                  <affiliation ref="#struct-1067373"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">flagship_health</idno>
                <idno type="halJournalId" status="VALID">127327</idno>
                <idno type="issn">2218-273X</idno>
                <title level="j">Biomolecules</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">15</biblScope>
                  <date type="datePub">2025-04-30</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/biom15050649</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Molecular dynamics</term>
                <term xml:lang="en">Nucleosome</term>
                <term xml:lang="en">Uracil base excision</term>
                <term xml:lang="en">Single-strand break</term>
                <term xml:lang="en">DNA repair</term>
                <term xml:lang="en">DNA damage</term>
                <term xml:lang="en">DNA damage DNA repair Single-strand break Uracil base excision Nucleosome Molecular dynamics</term>
              </keywords>
              <classCode scheme="halDomain" n="phys">Physics [physics]</classCode>
              <classCode scheme="halDomain" n="spi">Engineering Sciences [physics]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>&lt;div&gt;&lt;p&gt;The DNA base-excision repair (BER) pathway shares the second part of its enzymatic chain with the single-strand break (SSB) repair pathway. BER is initiated by a glycosylase, such as UDG, while SSBR is initiated by the multifunctional enzyme PARP1. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chains, and become even more complex when considering the realistic environment of damage to the DNA in the nucleosome. We performed molecular dynamics computer simulations of the interaction between the glycosylase UDG and a mutated uracil (as could result from oxidative deamination of cytosine), and between the Zn1-Zn2 fragment of PARP1 and a simulated SSB. The model system is a whole nucleosome in which DNA damage is inserted at various typical positions along the 145-bp sequence. It is shown that damage recognition by the enzymes requires very strict conditions, unlikely to be matched by pure random search along the DNA. We propose that mechanical deformation of the DNA around the defective sites may help signaling the presence of the defect, accelerating the search process.&lt;/p&gt;&lt;/div&gt;</p>
            </abstract>
            <particDesc>
              <org type="ir" xml:id="fr-esr-fdr-ir-064">
                <orgName type="acronym">GENCI</orgName>
                <idno type="wikidata">Q3093180</idno>
              </org>
            </particDesc>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1066983" status="VALID">
          <idno type="IdRef">138736421</idno>
          <idno type="ISNI">0000000403683863</idno>
          <idno type="RNSR">199812849E</idno>
          <idno type="ROR">https://ror.org/02q4res37</idno>
          <idno type="Wikidata">Q3151942</idno>
          <orgName>Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520</orgName>
          <orgName type="acronym">IEMN</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>[Univ. Lille, CNRS, Centrale Lille Institut, Junia, Univ. Polytechnique Hauts-de-France] ––Laboratoire Central – Cité Scientifique – Avenue Poincaré – CS 60069 – 59652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.iemn.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-120930" type="direct"/>
            <relation active="#struct-374570" type="direct"/>
            <relation name="UMR8520" active="#struct-441569" type="direct"/>
            <relation active="#struct-1001263" type="direct"/>
            <relation active="#struct-1059196" type="direct"/>
            <relation active="#struct-300877" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1067373" status="VALID">
          <idno type="RNSR">199223911E</idno>
          <orgName>Physique - IEMN</orgName>
          <orgName type="acronym">PHYSIQUE - IEMN</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Groupe Physique - (Physics group) - IEMN UMR8520</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.iemn.fr/la-recherche/les-groupes/physique</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1066983" type="direct"/>
            <relation active="#struct-120930" type="indirect"/>
            <relation active="#struct-374570" type="indirect"/>
            <relation name="UMR8520" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1001263" type="indirect"/>
            <relation active="#struct-1059196" type="indirect"/>
            <relation active="#struct-300877" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1004619" status="VALID">
          <idno type="IdRef">249814935</idno>
          <idno type="ISNI">0000000512425943</idno>
          <idno type="RNSR">202023551S</idno>
          <idno type="ROR">https://ror.org/05x9zmx47</idno>
          <idno type="Wikidata">Q116959474</idno>
          <orgName>Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277</orgName>
          <orgName type="acronym">CANTHER</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Laboratoire CANTHER, UMR 9020 CNRS-1277 Inserm -- Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers - Université de Lille - Bâtiment Cancer - Place de Verdun -59000 LILLE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.canther.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300166" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation name="U1277" active="#struct-303623" type="direct"/>
            <relation name="UMR9020" active="#struct-374570" type="direct"/>
            <relation name="UMR9020" active="#struct-425779" type="direct"/>
            <relation name="UMR9020" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1001889" status="VALID">
          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <idno type="ROR">https://ror.org/02g6y2720</idno>
          <idno type="Wikidata">Q30262465</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>UGSF INRAE -  Cité scientifique -  Bat C9, 001 RDC - 369 rue Jules Guesde - BP 20039 - 59651 VILLENEUVE D'ASCQ CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ugsf.univ-lille.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR8576" active="#struct-374570" type="direct"/>
            <relation name="UMR8576" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-120930" status="VALID">
          <idno type="IdRef">256304629</idno>
          <idno type="ISNI">0000000122034461</idno>
          <idno type="ROR">https://ror.org/01x441g73</idno>
          <orgName>Centrale Lille</orgName>
          <desc>
            <address>
              <addrLine>École Centrale de Lille - Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://centralelille.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1001263" status="VALID">
          <idno type="IdRef">242335675</idno>
          <idno type="ROR">https://ror.org/02ezch769</idno>
          <orgName>Université Polytechnique Hauts-de-France</orgName>
          <orgName type="acronym">UPHF</orgName>
          <date type="start">2019-09-09</date>
          <desc>
            <address>
              <addrLine>Campus Mont Houy59313 Valenciennes Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uphf.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1059196" status="VALID">
          <idno type="IdRef">258598026</idno>
          <idno type="ROR">https://ror.org/02evec030</idno>
          <orgName>JUNIA</orgName>
          <orgName type="acronym">JUNIA</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>2 Rue Norbert Segard59014 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.junia.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300877" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300877" status="VALID">
          <idno type="IdRef">026582481</idno>
          <idno type="ROR">https://ror.org/025s1b152</idno>
          <orgName>Université catholique de Lille</orgName>
          <orgName type="acronym">UCL</orgName>
          <desc>
            <address>
              <addrLine>60 boulevard Vauban - 59800 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-catholille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300166" status="VALID">
          <idno type="ROR">https://ror.org/05k9skc85</idno>
          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>
            <address>
              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-57046" status="VALID">
          <idno type="anr">ANR-21-CE45-0032</idno>
          <orgName>DYPROSOME</orgName>
          <desc>Dynamique des proteines de reparation de l'ADN dans le nucleosome</desc>
          <date type="start">2021</date>
        </org>
        <org type="europeanProject" xml:id="projeurop-714304" status="VALID">
          <idno type="number">847568</idno>
          <idno type="program">H2020-MSCA-COFUND-2018</idno>
          <idno type="call">H2020-MSCA-COFUND-2018</idno>
          <orgName>PEARL</orgName>
          <desc>Programme for EArly-stage Researchers in Lille</desc>
          <date type="start">2019-09-09</date>
          <date type="end">2025-09-08</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>