<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05144878</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T19:16:39+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">An integrative and translational PK/PD modelling approach to explore the combined effect of polymyxin B and minocycline against &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;</title>
            <author role="aut">
              <persName>
                <forename type="first">Chenyan</forename>
                <surname>Zhao</surname>
              </persName>
              <idno type="idhal" notation="numeric">1559125</idno>
              <idno type="halauthorid" notation="string">3624388-1559125</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6910-8480</idno>
              <affiliation ref="#struct-1064593"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sanne</forename>
                <surname>van den Berg</surname>
              </persName>
              <idno type="idhal" notation="numeric">1251782</idno>
              <idno type="halauthorid" notation="string">1779194-1251782</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9209-0178</idno>
              <affiliation ref="#struct-308157"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Zhigang</forename>
                <surname>Wang</surname>
              </persName>
              <idno type="idhal" notation="numeric">1531120</idno>
              <idno type="halauthorid" notation="string">976362-1531120</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6415-2044</idno>
              <affiliation ref="#struct-219663"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anna</forename>
                <surname>Olsson</surname>
              </persName>
              <idno type="halauthorid">520911-0</idno>
              <affiliation ref="#struct-219663"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Aranzana-Climent</surname>
              </persName>
              <email type="md5">7ee5f3376415c6b23073848172d2a912</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">vincent-aranzana-climent</idno>
              <idno type="idhal" notation="numeric">1169274</idno>
              <idno type="halauthorid" notation="string">1173628-1169274</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1258-8054</idno>
              <affiliation ref="#struct-1094387"/>
              <affiliation ref="#struct-108271"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christer</forename>
                <surname>Malmberg</surname>
              </persName>
              <idno type="idhal" notation="numeric">1559126</idno>
              <idno type="halauthorid" notation="string">3624389-1559126</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3187-8732</idno>
              <affiliation ref="#struct-219663"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pernilla</forename>
                <surname>Lagerbäck</surname>
              </persName>
              <idno type="idhal" notation="numeric">1559127</idno>
              <idno type="halauthorid" notation="string">3624390-1559127</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9085-1348</idno>
              <affiliation ref="#struct-219663"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thomas</forename>
                <surname>Tängdén</surname>
              </persName>
              <idno type="idhal" notation="numeric">1559128</idno>
              <idno type="halauthorid" notation="string">1709931-1559128</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7142-9849</idno>
              <affiliation ref="#struct-327137"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anouk</forename>
                <surname>Muller</surname>
              </persName>
              <email type="md5">79281c7ecd0a3d8a6dd75faef9581ba7</email>
              <email type="domain">erasmusmc.nl</email>
              <idno type="idhal" notation="numeric">1251781</idno>
              <idno type="halauthorid" notation="string">2802974-1251781</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5042-6251</idno>
              <affiliation ref="#struct-308157"/>
              <affiliation ref="#struct-1005218"/>
              <affiliation ref="#struct-1202961"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elisabet</forename>
                <surname>Nielsen</surname>
              </persName>
              <idno type="idhal" notation="numeric">1559129</idno>
              <idno type="halauthorid" notation="string">3049526-1559129</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0725-214X</idno>
              <affiliation ref="#struct-1064593"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Lena</forename>
                <surname>Friberg</surname>
              </persName>
              <email type="md5">330a346bfdea9b6b26932638ab498694</email>
              <email type="domain">farmaci.uu.se</email>
              <idno type="idhal" notation="numeric">1334533</idno>
              <idno type="halauthorid" notation="string">1793921-1334533</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2979-679X</idno>
              <affiliation ref="#struct-1064593"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Alexia</forename>
                <surname>Chauzy</surname>
              </persName>
              <email type="md5">d345ce90b32b5926dbea31d616564376</email>
              <email type="domain">univ-poitiers.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-07-04 15:56:26</date>
              <date type="whenModified">2025-07-21 09:38:24</date>
              <date type="whenReleased">2025-07-04 15:56:26</date>
              <date type="whenProduced">2025-03</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="799021">
                <persName>
                  <forename>Alexia</forename>
                  <surname>Chauzy</surname>
                </persName>
                <email type="md5">d345ce90b32b5926dbea31d616564376</email>
                <email type="domain">univ-poitiers.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05144878</idno>
            <idno type="halUri">https://hal.science/hal-05144878</idno>
            <idno type="halBibtex">zhao:hal-05144878</idno>
            <idno type="halRefHtml">&lt;i&gt;International Journal of Antimicrobial Agents&lt;/i&gt;, 2025, 65 (3), pp.107443. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ijantimicag.2025.107443"&gt;&amp;#x27E8;10.1016/j.ijantimicag.2025.107443&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">International Journal of Antimicrobial Agents, 2025, 65 (3), pp.107443. &amp;#x27E8;10.1016/j.ijantimicag.2025.107443&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-POITIERS">Université de Poitiers</idno>
            <idno type="stamp" n="PHAR">Pharmacologie des anti-infectieux et antibiorésistance</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">An integrative and translational PK/PD modelling approach to explore the combined effect of polymyxin B and minocycline against &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Chenyan</forename>
                    <surname>Zhao</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1559125</idno>
                  <idno type="halauthorid" notation="string">3624388-1559125</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6910-8480</idno>
                  <affiliation ref="#struct-1064593"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sanne</forename>
                    <surname>van den Berg</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1251782</idno>
                  <idno type="halauthorid" notation="string">1779194-1251782</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9209-0178</idno>
                  <affiliation ref="#struct-308157"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Zhigang</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1531120</idno>
                  <idno type="halauthorid" notation="string">976362-1531120</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6415-2044</idno>
                  <affiliation ref="#struct-219663"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anna</forename>
                    <surname>Olsson</surname>
                  </persName>
                  <idno type="halauthorid">520911-0</idno>
                  <affiliation ref="#struct-219663"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Aranzana-Climent</surname>
                  </persName>
                  <email type="md5">7ee5f3376415c6b23073848172d2a912</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">vincent-aranzana-climent</idno>
                  <idno type="idhal" notation="numeric">1169274</idno>
                  <idno type="halauthorid" notation="string">1173628-1169274</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1258-8054</idno>
                  <affiliation ref="#struct-1094387"/>
                  <affiliation ref="#struct-108271"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christer</forename>
                    <surname>Malmberg</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1559126</idno>
                  <idno type="halauthorid" notation="string">3624389-1559126</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3187-8732</idno>
                  <affiliation ref="#struct-219663"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pernilla</forename>
                    <surname>Lagerbäck</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1559127</idno>
                  <idno type="halauthorid" notation="string">3624390-1559127</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9085-1348</idno>
                  <affiliation ref="#struct-219663"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thomas</forename>
                    <surname>Tängdén</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1559128</idno>
                  <idno type="halauthorid" notation="string">1709931-1559128</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7142-9849</idno>
                  <affiliation ref="#struct-327137"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anouk</forename>
                    <surname>Muller</surname>
                  </persName>
                  <email type="md5">79281c7ecd0a3d8a6dd75faef9581ba7</email>
                  <email type="domain">erasmusmc.nl</email>
                  <idno type="idhal" notation="numeric">1251781</idno>
                  <idno type="halauthorid" notation="string">2802974-1251781</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5042-6251</idno>
                  <affiliation ref="#struct-308157"/>
                  <affiliation ref="#struct-1005218"/>
                  <affiliation ref="#struct-1202961"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elisabet</forename>
                    <surname>Nielsen</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1559129</idno>
                  <idno type="halauthorid" notation="string">3049526-1559129</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0725-214X</idno>
                  <affiliation ref="#struct-1064593"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Lena</forename>
                    <surname>Friberg</surname>
                  </persName>
                  <email type="md5">330a346bfdea9b6b26932638ab498694</email>
                  <email type="domain">farmaci.uu.se</email>
                  <idno type="idhal" notation="numeric">1334533</idno>
                  <idno type="halauthorid" notation="string">1793921-1334533</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2979-679X</idno>
                  <affiliation ref="#struct-1064593"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">159852</idno>
                <idno type="issn">0924-8579</idno>
                <idno type="eissn">0924-8579</idno>
                <title level="j">International Journal of Antimicrobial Agents</title>
                <imprint>
                  <biblScope unit="volume">65</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">107443</biblScope>
                  <date type="datePub">2025-03</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ijantimicag.2025.107443</idno>
              <idno type="pubmed">39793934</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Translational pharmacokinetic–pharmacodynamic modelling</term>
                <term xml:lang="en">Antibiotic combination</term>
                <term xml:lang="en">Minocycline</term>
                <term xml:lang="en">Polymyxin B</term>
                <term xml:lang="en">Semi-mechanistic pharmacokinetic–pharmacodynamic model</term>
              </keywords>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Anti-Bacterial Agents* / administration &amp; dosage</classCode>
              <classCode scheme="mesh">Mice</classCode>
              <classCode scheme="mesh">Microbial Sensitivity Tests</classCode>
              <classCode scheme="mesh">Minocycline* / administration &amp; dosage</classCode>
              <classCode scheme="mesh">Minocycline* / pharmacokinetics</classCode>
              <classCode scheme="mesh">Minocycline* / pharmacology</classCode>
              <classCode scheme="mesh">Polymyxin B* / administration &amp; dosage</classCode>
              <classCode scheme="mesh">Polymyxin B* / pharmacokinetics</classCode>
              <classCode scheme="mesh">Polymyxin B* / pharmacology</classCode>
              <classCode scheme="mesh">Anti-Bacterial Agents* / pharmacokinetics</classCode>
              <classCode scheme="mesh">Anti-Bacterial Agents* / pharmacology</classCode>
              <classCode scheme="mesh">Disease Models, Animal</classCode>
              <classCode scheme="mesh">Drug Therapy, Combination</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Klebsiella Infections* / drug therapy</classCode>
              <classCode scheme="mesh">Klebsiella Infections* / microbiology</classCode>
              <classCode scheme="mesh">Klebsiella pneumoniae* / drug effects</classCode>
              <classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>&lt;b&gt;Objectives:&lt;/b&gt; To expand a translational pharmacokinetic-pharmacodynamic (PK/PD) modelling approach for assessing the combined effect of polymyxin B and minocycline against &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;.&lt;br /&gt;&lt;b&gt;Methods:&lt;/b&gt; A PK/PD model developed based on in vitro static time-kill experiments of one strain (ARU613) was first translated to characterize that of a more susceptible strain (ARU705), and thereafter to dynamic time-kill experiments (both strains) and to a murine thigh infection model (ARU705 only). The PK/PD model was updated stepwise using accumulated data. Predictions of bacterial killing in humans were performed.&lt;br /&gt;&lt;b&gt;Results:&lt;/b&gt; The same model structure could be used in each translational step, with parameters being re-estimated. Dynamic data were well predicted by static-data-based models. The in &lt;i&gt;vitro/in vivo&lt;/i&gt; differences were primarily quantified as a change in polymyxin B effect: a lower killing rate constant &lt;i&gt;in vivo&lt;/i&gt; compared with &lt;i&gt;in vitro&lt;/i&gt; (concentration of 3 mg/L corresponds to 0.05/h and 57/h, respectively), and a slower adaptive resistance rate (the constant in vivo was 2.5% of that &lt;i&gt;in vitro&lt;/i&gt;). There was no significant difference in polymyxin B-minocycline interaction functions. Predictions based on both &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; parameters indicated that the combination has a greater-than-monotherapy antibacterial effect in humans, forecasting a reduction of approximately 5 and 2 log&lt;sub&gt;10&lt;/sub&gt; colony-forming units/mL at 24 h, respectively, under combined therapy, while the maximum bacterial load was reached in monotherapy.&lt;br /&gt;&lt;b&gt;Conclusions:&lt;/b&gt; This study demonstrated the utility of the PK/PD modelling approach to understand translation of antibiotic effects across experimental systems, and showed a promising antibacterial effect of polymyxin B and minocycline in combination against &lt;i&gt;K. pneumoniae&lt;/i&gt;.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-1064593" status="VALID">
          <orgName>Department of Pharmacy, Uppsala University</orgName>
          <date type="start">2021-03-04</date>
          <desc>
            <address>
              <addrLine>Uppsala</addrLine>
              <country key="SE"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-50873" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-308157" status="VALID">
          <idno type="ROR">https://ror.org/018906e22</idno>
          <orgName>Erasmus University Medical Center [Rotterdam]</orgName>
          <orgName type="acronym">Erasmus MC</orgName>
          <desc>
            <address>
              <addrLine>Rotterdam</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">http://www.erasmusmc.nl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-219663" status="VALID">
          <idno type="IdRef">026431661</idno>
          <idno type="ROR">https://ror.org/048a87296</idno>
          <orgName>Uppsala Universitet [Uppsala]</orgName>
          <desc>
            <address>
              <addrLine>P.O. Box 256, SE-751 05 Uppsala</addrLine>
              <country key="SE"/>
            </address>
            <ref type="url">http://www.uu.se/en</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1094387" status="VALID">
          <idno type="RNSR">201220154J</idno>
          <idno type="ROR">https://ror.org/041v99f68</idno>
          <idno type="Wikidata">Q51779859</idno>
          <orgName>Pharmacologie des anti-infectieux et antibiorésistance [U 1070]</orgName>
          <orgName type="acronym">PHAR2 [Poitiers]</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Pôle Biologie Santé - Université de Poitiers - Bâtiment B36 - 1 rue Georges Bonnet - TSA 51106 - 86073 Poitiers Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://phar.labo.univ-poitiers.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR-S 1070" active="#struct-54493" type="direct"/>
            <relation name="U1070" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-108271" status="VALID">
          <idno type="IdRef">034799990</idno>
          <idno type="ISNI">0000000121696383</idno>
          <orgName>Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie]</orgName>
          <orgName type="acronym">UFR Santé [Poitiers]</orgName>
          <date type="start">1968-10-01</date>
          <desc>
            <address>
              <addrLine>Bâtiment D1 – 6 rue de la Milétrie – TSA 51 115 – 86073 Poitiers Cedex 9 – France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://medphar.univ-poitiers.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-54493" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-327137" status="VALID">
          <idno type="ROR">https://ror.org/01apvbh93</idno>
          <orgName>Uppsala University Hospital</orgName>
          <desc>
            <address>
              <addrLine>Akademiska sjukhuset, SE-751 85 Uppsala</addrLine>
              <country key="SE"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1005218" status="VALID">
          <orgName>Haaglanden Medisch Centrum [Nederland] = Haaglanden Medical Center [Netherlands]</orgName>
          <orgName type="acronym">HMC</orgName>
          <desc>
            <address>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.haaglandenmc.nl/english/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1202961" status="VALID">
          <orgName>Center for Antimicrobial Treatment Optimization Rotterdam</orgName>
          <orgName type="acronym">CATOR</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="NL"/>
            </address>
            <ref type="url">https://cator010.nl/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-308157" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-50873" status="VALID">
          <idno type="IdRef">026431661</idno>
          <idno type="ROR">https://ror.org/048a87296</idno>
          <orgName>Uppsala University</orgName>
          <desc>
            <address>
              <addrLine>Box 256, SE-751 05 Uppsala</addrLine>
              <country key="SE"/>
            </address>
            <ref type="url">http://www.uu.se/en/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-54493" status="VALID">
          <idno type="IdRef">026403765</idno>
          <idno type="ISNI">0000000121606368</idno>
          <idno type="ROR">https://ror.org/04xhy8q59</idno>
          <idno type="Wikidata">Q661056</idno>
          <orgName>Université de Poitiers =  University of Poitiers</orgName>
          <orgName type="acronym">UP</orgName>
          <desc>
            <address>
              <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-poitiers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>