Article Dans Une Revue Asian Journal of Research and Reports in Ophthalmology Année : 2024

Ciclosporin Eye Drops in Ocular Graft-Versus-Host Disease: A Case Report

Résumé

Aims: To report a case of severe ocular graft-versus-host disease (GVHD) managed with topical ciclosporin. Introduction: Ocular graft-versus host disease is a rare and often misdiagnosed aetiology of dry eye syndrome. Case: We report a case of young women presenting with a severe and bilateral ocular surface inflammation with filamentous keratitis, posterior blepharitis, Meibomian gland dysfunction and neovascular invasion. Ocular GVHD was diagnosed due to severe dry eye symptoms and a history of allogeneic haematopoietic stem cell transplantation. Immunosuppressive treatment resulted in a spectacular anatomical and clinical improvement, rapid resolution of symptoms and improvement in visual acuity. Conclusion: Ocular GVHD should be considered in any severe dry eye syndrome associated with allogeneic bone marrow transplantation. Topical immunosuppressive therapies have revolutionised the curative management of these patients.

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Dates et versions

hal-05133795 , version 1 (28-06-2025)

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  • HAL Id : hal-05133795 , version 1

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El Filali El Mehdi, Farah Benelkadri, Houssaine Ait Lhaj, Mohamed Kriet, Fouad El Asri. Ciclosporin Eye Drops in Ocular Graft-Versus-Host Disease: A Case Report. Asian Journal of Research and Reports in Ophthalmology, 2024, 7 (1), pp.102-106. ⟨hal-05133795⟩
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