Article Dans Une Revue ACS Omega Année : 2025

New Cyclopeptide and γ-Butyrolactone Derivatives from an Endophytic Strain of Cophinforma mamane

Résumé

From an endophytic strain of Cophinforma mamane isolated from the leaves of Bixa orellana, a previously undescribed γ-butyrolactone compound (2) and three new cyclopentapeptides (3-5) have been isolated from the same strain, along with the known (4R)-striatisporolide A (1). Their structures were elucidated through extensive spectral analysis and DP4+ calculations. The two γ-butyrolactone derivatives (1, 2) exhibited moderate inhibitory activity against axenic Leishmania infantum amastigotes (IC50 = 13.33 and 4.43 μM, respectively), while only compound 2 displayed cytotoxic activity on Jurkat cells (17% growth inhibition at 1 μg/mL) and weak antibacterial activity against Enterococcus faecalis (MIC = 64 μg/mL).

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hal-05121071 , version 1 (19-06-2025)

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Clara Litot, Marieke Vansteelandt, Sergio Ortiz, Fatima Barakat, Elise Crossay, et al.. New Cyclopeptide and γ-Butyrolactone Derivatives from an Endophytic Strain of Cophinforma mamane. ACS Omega, 2025, 10 (21), pp.21738-21746. ⟨10.1021/acsomega.5c01292⟩. ⟨hal-05121071⟩
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