Article Dans Une Revue International Journal of Systematic and Evolutionary Microbiology Année : 2025

Faecalibacterium langellae sp. nov. isolated from human faeces

Adeline Ang Li Xuan
  • Fonction : Auteur
Véronique Robert
Atsushi Hisatomi
  • Fonction : Auteur
Masahiro Hirasaki
  • Fonction : Auteur
Shintaro Maeno
  • Fonction : Auteur
Moriya Ohkuma
Mitsuo Sakamoto
Akihito Endo

Résumé

The genus Faecalibacterium is one of the major butyrate-producing bacteria in the human gut. Due to its production of beneficial metabolites and reduced populations in diseased patients, it is regarded as a potential biomarker of healthy gut microbiota. Strains Collection Nationale de Cultures de Microorganismes (CNCM) I-4540 and CNCM I-4541 were isolated from faeces of a healthy elderly and a healthy adult respectively. In this study, we conducted a taxonomic analysis of these strains. Phylogenetic analyses based on 16S rRNA gene and rpoA gene sequences revealed that the two strains belong to the genus Faecalibacterium . A core gene phylogenetic tree further supported their phylogenetic placement. CNCM I-4540 shared an average nucleotide identity (ANI) value of 96.7% and a digital DNA–DNA hybridization (dDDH) value of 74.3% with Faecalibacterium taiwanense HLW78 T , indicating that CNCM I-4540 should be classified as F. taiwanense . In contrast, CNCM I-4541 did not exhibit ANI or dDDH values above the species threshold for any known species within the genus Faecalibacterium . These findings indicate that CNCM I-4541 represents a novel species within the genus Faecalibacterium , for which the name Faecalibacterium langellae sp. nov. is proposed. The type strain is CNCM I-4541 T (=CIP 112513 T =JCM 39552 T ).

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hal-05106084 , version 1 (10-07-2025)

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Adeline Ang Li Xuan, Véronique Robert, Atsushi Hisatomi, Masahiro Hirasaki, Shintaro Maeno, et al.. Faecalibacterium langellae sp. nov. isolated from human faeces. International Journal of Systematic and Evolutionary Microbiology, 2025, 75 (6), ⟨10.1099/ijsem.0.006804⟩. ⟨hal-05106084⟩
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