<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05098483</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-09T18:14:47+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells</title>
            <author role="aut">
              <persName>
                <forename type="first">Carolina</forename>
                <surname>Duarte Hospital</surname>
              </persName>
              <idno type="idhal" notation="numeric">1413212</idno>
              <idno type="halauthorid" notation="string">3183606-1413212</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6781-1903</idno>
              <affiliation ref="#struct-1226652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Tête</surname>
              </persName>
              <email type="md5">ab108aa67448075b246f31282c5bd05c</email>
              <email type="domain">u-paris.fr</email>
              <idno type="idhal" notation="string">tete-arnaud</idno>
              <idno type="idhal" notation="numeric">1395999</idno>
              <idno type="halauthorid" notation="string">1172401-1395999</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1097-3944</idno>
              <affiliation ref="#struct-1226652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kloé</forename>
                <surname>Debizet</surname>
              </persName>
              <idno type="halauthorid">2876165-0</idno>
              <affiliation ref="#struct-1226652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clémence</forename>
                <surname>Rives</surname>
              </persName>
              <email type="md5">0eec421a6afb85d2d7d813bbf0a9e3c0</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="numeric">1087721</idno>
              <idno type="halauthorid" notation="string">2124518-1087721</idno>
              <idno type="IDREF">https://www.idref.fr/284489077</idno>
              <affiliation ref="#struct-1612996"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jules</forename>
                <surname>Imler</surname>
              </persName>
              <idno type="idhal" notation="numeric">1539163</idno>
              <idno type="halauthorid" notation="string">3183607-1539163</idno>
              <idno type="ORCID">https://orcid.org/0009-0009-0309-3410</idno>
              <affiliation ref="#struct-1226652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sofiane</forename>
                <surname>Safi-Stibler</surname>
              </persName>
              <idno type="halauthorid">1239246-0</idno>
              <affiliation ref="#struct-1004693"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lara</forename>
                <surname>Gales</surname>
              </persName>
              <email type="md5">a8adba861f5f1041c795f950426387a9</email>
              <email type="domain">insa-toulouse.fr</email>
              <idno type="idhal" notation="numeric">976067</idno>
              <idno type="halauthorid" notation="string">992781-976067</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1233-2032</idno>
              <affiliation ref="#struct-1612938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Floriant</forename>
                <surname>Bellvert</surname>
              </persName>
              <email type="md5">d208c171f8b7e9ef67bcb7b8e097469c</email>
              <email type="domain">insa-toulouse.fr</email>
              <idno type="idhal" notation="string">floriant-bellvert</idno>
              <idno type="idhal" notation="numeric">763226</idno>
              <idno type="halauthorid" notation="string">497013-763226</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3259-8655</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=N7KaQ-4AAAAJ</idno>
              <affiliation ref="#struct-1612938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julien</forename>
                <surname>Dairou</surname>
              </persName>
              <email type="md5">5b0869c2fec6b1ee159463b66a0e6b03</email>
              <email type="domain">u-paris.fr</email>
              <idno type="idhal" notation="string">julien-dairou</idno>
              <idno type="idhal" notation="numeric">1153917</idno>
              <idno type="halauthorid" notation="string">249383-1153917</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1767-0572</idno>
              <idno type="IDREF">https://www.idref.fr/089054989</idno>
              <affiliation ref="#struct-1004771"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Auriane</forename>
                <surname>Hagimont</surname>
              </persName>
              <idno type="halauthorid">3561703-0</idno>
              <affiliation ref="#struct-1612816"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Agnès</forename>
                <surname>Burel</surname>
              </persName>
              <idno type="idhal" notation="numeric">1421056</idno>
              <idno type="halauthorid" notation="string">415849-1421056</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2990-3345</idno>
              <affiliation ref="#struct-441367"/>
              <affiliation ref="#struct-544521"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dominique</forename>
                <surname>Lagadic-Gossmann</surname>
              </persName>
              <email type="md5">c91db502a37324930f9b7236f65b701a</email>
              <email type="domain">univ-rennes1.fr</email>
              <idno type="idhal" notation="numeric">838095</idno>
              <idno type="halauthorid" notation="string">193094-838095</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4888-236X</idno>
              <affiliation ref="#struct-182194"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Robert</forename>
                <surname>Barouki</surname>
              </persName>
              <email type="md5">3738f3ce7cf366090fac6973dfbb3f44</email>
              <email type="domain">parisdescartes.fr</email>
              <idno type="idhal" notation="numeric">1183338</idno>
              <idno type="halauthorid" notation="string">359128-1183338</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9471-399X</idno>
              <idno type="IDREF">https://www.idref.fr/061063266</idno>
              <idno type="VIAF">https://viaf.org/viaf/211852213</idno>
              <idno type="ISNI">http://isni.org/isni/0000000432133932</idno>
              <affiliation ref="#struct-1226652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jerry</forename>
                <surname>W Shay</surname>
              </persName>
              <idno type="idhal" notation="numeric">1413215</idno>
              <idno type="halauthorid" notation="string">3561702-1413215</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5052-0627</idno>
              <affiliation ref="#struct-545073"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean</forename>
                <surname>Bastin</surname>
              </persName>
              <email type="md5">a0fef7a4f469ae3ceb67f14fe066d605</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">1026749</idno>
              <idno type="halauthorid" notation="string">1299163-1026749</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8350-8667</idno>
              <affiliation ref="#struct-1004777"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Mouillet-Richard</surname>
              </persName>
              <email type="md5">042cea28530d0813e5c21be4673699f1</email>
              <email type="domain">parisdescartes.fr</email>
              <idno type="idhal" notation="numeric">800781</idno>
              <idno type="halauthorid" notation="string">939289-800781</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8950-1949</idno>
              <idno type="IDREF">https://www.idref.fr/171682475</idno>
              <affiliation ref="#struct-1004777"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anthony</forename>
                <surname>Lemarié</surname>
              </persName>
              <email type="md5">d093fdb1cf2d06f9da4af02184045a20</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">anthony-lemarie</idno>
              <idno type="idhal" notation="numeric">1223931</idno>
              <idno type="halauthorid" notation="string">800641-1223931</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6523-4962</idno>
              <idno type="IDREF">https://www.idref.fr/06999031X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-4018-2017</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=BVpVNskAAAAJ</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-4018-2017</idno>
              <affiliation ref="#struct-1612816"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fatima</forename>
                <surname>Djouadi</surname>
              </persName>
              <idno type="idhal" notation="numeric">801814</idno>
              <idno type="halauthorid" notation="string">1299162-801814</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0350-0935</idno>
              <idno type="IDREF">https://www.idref.fr/176485961</idno>
              <affiliation ref="#struct-1004777"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sandrine</forename>
                <surname>Ellero-Simatos</surname>
              </persName>
              <email type="md5">5480f0ea2d38e588588da6a10ecd9c9f</email>
              <email type="domain">inra.fr</email>
              <idno type="idhal" notation="string">sandrine-ellero-simatos</idno>
              <idno type="idhal" notation="numeric">1236764</idno>
              <idno type="halauthorid" notation="string">1833643-1236764</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=axLWPQQAAAAJ</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9282-1804</idno>
              <affiliation ref="#struct-1612996"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xavier</forename>
                <surname>Coumoul</surname>
              </persName>
              <email type="md5">5694c1fb05470336a431371310e4cb1d</email>
              <email type="domain">univ-paris5.fr</email>
              <idno type="idhal" notation="string">xavier-coumoul</idno>
              <idno type="idhal" notation="numeric">176060</idno>
              <idno type="halauthorid" notation="string">16147-176060</idno>
              <idno type="IDREF">https://www.idref.fr/150232683</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2928-9648</idno>
              <affiliation ref="#struct-1226652"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Judith</forename>
                <surname>Favier</surname>
              </persName>
              <email type="md5">4554dc04ec1a1efe4ef31f99e37e7598</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">1179111</idno>
              <idno type="halauthorid" notation="string">615553-1179111</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8190-5853</idno>
              <affiliation ref="#struct-1004777"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Sylvie</forename>
                <surname>Bortoli</surname>
              </persName>
              <email type="md5">a9f7923018d12a2ed903d389f6272b2f</email>
              <email type="domain">u-paris.fr</email>
              <idno type="idhal" notation="numeric">1396000</idno>
              <idno type="halauthorid" notation="string">1055517-1396000</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1008-1241</idno>
              <affiliation ref="#struct-1226652"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
            <funder ref="#projanses-ANSES-19-EST-186"/>
            <funder>this work was supported by INSERM, Université Paris Cité, The French National Research Program for Environmental and Occupational Health of Anses (2019/1/186) (SB, JF), the AFB-EcoPhyto plan II of the French Ministry of Agriculture (SB, JF), the SIRIC CARPEM (grant 2020 “Emergence and Innovation, FD) and the Ligue Nationale contre le Cancer (JF). CDH was financed by the Paraguayan Don Carlos Antonio Lopez National Scholarship Program for Higher Education Abroad (BECAL). The authors warmly acknowledge Dr Stéphanie Dupuy and the cytometry platform of BioMedTech Facilities (INSERM US36, CNRS UMS2009, Université Paris Cité) for her assistance in cytometry protocols and analysis. AL and AH acknowledge Fondation pour la Recherche Médicale and Holimitox network for supporting.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-06-05 09:39:16</date>
              <date type="whenModified">2026-04-23 15:38:40</date>
              <date type="whenReleased">2025-06-05 09:39:19</date>
              <date type="whenProduced">2025</date>
              <date type="whenEndEmbargoed">2025-06-05</date>
              <ref type="file" target="https://hal.science/hal-05098483v1/document">
                <date notBefore="2025-06-05"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-05098483v1/file/1-s2.0-S0160412025002545-main.pdf" id="file-5098487-4409845">
                <date notBefore="2025-06-05"/>
              </ref>
              <ref type="annex" n="0" target="https://hal.science/hal-05098483v1/file/ScienceDirect_files_05Jun2025_07-38-50.210.zip" id="file-5098487-4409846">
                <date notBefore="2025-06-05"/>
              </ref>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05098483</idno>
            <idno type="halUri">https://hal.science/hal-05098483</idno>
            <idno type="halBibtex">duartehospital:hal-05098483</idno>
            <idno type="halRefHtml">&lt;i&gt;Environment International&lt;/i&gt;, 2025, 199, pp.109503. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.envint.2025.109503"&gt;&amp;#x27E8;10.1016/j.envint.2025.109503&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Environment International, 2025, 199, pp.109503. &amp;#x27E8;10.1016/j.envint.2025.109503&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC 4.0 - Attribution - Non-commercial use<ref corresp="#file-5098487-4409845"/><ref corresp="#file-5098487-4409846"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="EPHE">École Pratique des Hautes Études</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="IRSET">Institut de Recherche en Santé, Environnement et Travail</idno>
            <idno type="stamp" n="CORDELIERS" corresp="SORBONNE-UNIVERSITE">Centre de recherche des Cordeliers</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="IRSET-TREC" corresp="IRSET">TRANSCRIPTION, ENVIRONMENT and CANCER (TREC)</idno>
            <idno type="stamp" n="IRSET-NEED" corresp="IRSET">NEUROENDOCRINE EFFECTS OF ENDOCRINE DISRUPTORS</idno>
            <idno type="stamp" n="IRSET-TNGC" corresp="IRSET">Recherches épidémiologiques sur l'environnement, la reproduction et le développement</idno>
            <idno type="stamp" n="BIOSIT">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="IRSET-3" corresp="IRSET">SPARFEL - PODECHARD - Stress, membrane et signalisation (SMS)</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="TEST-DEV">TEST-DEV</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="UP-SCIENCES">Université Paris Cité - Faculté des Sciences</idno>
            <idno type="stamp" n="EPHE-PSL" corresp="PSL">École Pratique des Hautes Études - PSL</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="TOXALIM" corresp="INRAE">ToxAlim</idno>
            <idno type="stamp" n="INRAEOCCITANIETOULOUSE" corresp="INRAE">INRAE Occitanie Toulouse</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="METABOHUB">Metabohub : Infrastructure nationale en métabolomique et fluxomique </idno>
            <idno type="stamp" n="CRCT">CRCT</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="RESEAU-EAU">Réseau "Systèmes Agricoles et Eau"</idno>
            <idno type="stamp" n="ENVT">École Nationale Vétérinaire de Toulouse </idno>
            <idno type="stamp" n="SUPRA_BIOLOGIE">Biologie hors MNHN &amp; stations</idno>
            <idno type="stamp" n="LCBPT">Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques - UMR 8601</idno>
            <idno type="stamp" n="ANSES-PNREST">Anses – Programme national de recherche Environnement-Santé-Travail</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Carolina</forename>
                    <surname>Duarte Hospital</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1413212</idno>
                  <idno type="halauthorid" notation="string">3183606-1413212</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6781-1903</idno>
                  <affiliation ref="#struct-1226652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Tête</surname>
                  </persName>
                  <email type="md5">ab108aa67448075b246f31282c5bd05c</email>
                  <email type="domain">u-paris.fr</email>
                  <idno type="idhal" notation="string">tete-arnaud</idno>
                  <idno type="idhal" notation="numeric">1395999</idno>
                  <idno type="halauthorid" notation="string">1172401-1395999</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1097-3944</idno>
                  <affiliation ref="#struct-1226652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kloé</forename>
                    <surname>Debizet</surname>
                  </persName>
                  <idno type="halauthorid">2876165-0</idno>
                  <affiliation ref="#struct-1226652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clémence</forename>
                    <surname>Rives</surname>
                  </persName>
                  <email type="md5">0eec421a6afb85d2d7d813bbf0a9e3c0</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="numeric">1087721</idno>
                  <idno type="halauthorid" notation="string">2124518-1087721</idno>
                  <idno type="IDREF">https://www.idref.fr/284489077</idno>
                  <affiliation ref="#struct-1612996"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jules</forename>
                    <surname>Imler</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1539163</idno>
                  <idno type="halauthorid" notation="string">3183607-1539163</idno>
                  <idno type="ORCID">https://orcid.org/0009-0009-0309-3410</idno>
                  <affiliation ref="#struct-1226652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sofiane</forename>
                    <surname>Safi-Stibler</surname>
                  </persName>
                  <idno type="halauthorid">1239246-0</idno>
                  <affiliation ref="#struct-1004693"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lara</forename>
                    <surname>Gales</surname>
                  </persName>
                  <email type="md5">a8adba861f5f1041c795f950426387a9</email>
                  <email type="domain">insa-toulouse.fr</email>
                  <idno type="idhal" notation="numeric">976067</idno>
                  <idno type="halauthorid" notation="string">992781-976067</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1233-2032</idno>
                  <affiliation ref="#struct-1612938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Floriant</forename>
                    <surname>Bellvert</surname>
                  </persName>
                  <email type="md5">d208c171f8b7e9ef67bcb7b8e097469c</email>
                  <email type="domain">insa-toulouse.fr</email>
                  <idno type="idhal" notation="string">floriant-bellvert</idno>
                  <idno type="idhal" notation="numeric">763226</idno>
                  <idno type="halauthorid" notation="string">497013-763226</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3259-8655</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=N7KaQ-4AAAAJ</idno>
                  <affiliation ref="#struct-1612938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julien</forename>
                    <surname>Dairou</surname>
                  </persName>
                  <email type="md5">5b0869c2fec6b1ee159463b66a0e6b03</email>
                  <email type="domain">u-paris.fr</email>
                  <idno type="idhal" notation="string">julien-dairou</idno>
                  <idno type="idhal" notation="numeric">1153917</idno>
                  <idno type="halauthorid" notation="string">249383-1153917</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1767-0572</idno>
                  <idno type="IDREF">https://www.idref.fr/089054989</idno>
                  <affiliation ref="#struct-1004771"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Auriane</forename>
                    <surname>Hagimont</surname>
                  </persName>
                  <idno type="halauthorid">3561703-0</idno>
                  <affiliation ref="#struct-1612816"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Agnès</forename>
                    <surname>Burel</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1421056</idno>
                  <idno type="halauthorid" notation="string">415849-1421056</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2990-3345</idno>
                  <affiliation ref="#struct-441367"/>
                  <affiliation ref="#struct-544521"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dominique</forename>
                    <surname>Lagadic-Gossmann</surname>
                  </persName>
                  <email type="md5">c91db502a37324930f9b7236f65b701a</email>
                  <email type="domain">univ-rennes1.fr</email>
                  <idno type="idhal" notation="numeric">838095</idno>
                  <idno type="halauthorid" notation="string">193094-838095</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4888-236X</idno>
                  <affiliation ref="#struct-182194"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Robert</forename>
                    <surname>Barouki</surname>
                  </persName>
                  <email type="md5">3738f3ce7cf366090fac6973dfbb3f44</email>
                  <email type="domain">parisdescartes.fr</email>
                  <idno type="idhal" notation="numeric">1183338</idno>
                  <idno type="halauthorid" notation="string">359128-1183338</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9471-399X</idno>
                  <idno type="IDREF">https://www.idref.fr/061063266</idno>
                  <idno type="VIAF">https://viaf.org/viaf/211852213</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000432133932</idno>
                  <affiliation ref="#struct-1226652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jerry</forename>
                    <surname>W Shay</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1413215</idno>
                  <idno type="halauthorid" notation="string">3561702-1413215</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5052-0627</idno>
                  <affiliation ref="#struct-545073"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean</forename>
                    <surname>Bastin</surname>
                  </persName>
                  <email type="md5">a0fef7a4f469ae3ceb67f14fe066d605</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">1026749</idno>
                  <idno type="halauthorid" notation="string">1299163-1026749</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8350-8667</idno>
                  <affiliation ref="#struct-1004777"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Mouillet-Richard</surname>
                  </persName>
                  <email type="md5">042cea28530d0813e5c21be4673699f1</email>
                  <email type="domain">parisdescartes.fr</email>
                  <idno type="idhal" notation="numeric">800781</idno>
                  <idno type="halauthorid" notation="string">939289-800781</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8950-1949</idno>
                  <idno type="IDREF">https://www.idref.fr/171682475</idno>
                  <affiliation ref="#struct-1004777"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anthony</forename>
                    <surname>Lemarié</surname>
                  </persName>
                  <email type="md5">d093fdb1cf2d06f9da4af02184045a20</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">anthony-lemarie</idno>
                  <idno type="idhal" notation="numeric">1223931</idno>
                  <idno type="halauthorid" notation="string">800641-1223931</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6523-4962</idno>
                  <idno type="IDREF">https://www.idref.fr/06999031X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-4018-2017</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=BVpVNskAAAAJ</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-4018-2017</idno>
                  <affiliation ref="#struct-1612816"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fatima</forename>
                    <surname>Djouadi</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">801814</idno>
                  <idno type="halauthorid" notation="string">1299162-801814</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0350-0935</idno>
                  <idno type="IDREF">https://www.idref.fr/176485961</idno>
                  <affiliation ref="#struct-1004777"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sandrine</forename>
                    <surname>Ellero-Simatos</surname>
                  </persName>
                  <email type="md5">5480f0ea2d38e588588da6a10ecd9c9f</email>
                  <email type="domain">inra.fr</email>
                  <idno type="idhal" notation="string">sandrine-ellero-simatos</idno>
                  <idno type="idhal" notation="numeric">1236764</idno>
                  <idno type="halauthorid" notation="string">1833643-1236764</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=axLWPQQAAAAJ</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9282-1804</idno>
                  <affiliation ref="#struct-1612996"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xavier</forename>
                    <surname>Coumoul</surname>
                  </persName>
                  <email type="md5">5694c1fb05470336a431371310e4cb1d</email>
                  <email type="domain">univ-paris5.fr</email>
                  <idno type="idhal" notation="string">xavier-coumoul</idno>
                  <idno type="idhal" notation="numeric">176060</idno>
                  <idno type="halauthorid" notation="string">16147-176060</idno>
                  <idno type="IDREF">https://www.idref.fr/150232683</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2928-9648</idno>
                  <affiliation ref="#struct-1226652"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Judith</forename>
                    <surname>Favier</surname>
                  </persName>
                  <email type="md5">4554dc04ec1a1efe4ef31f99e37e7598</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">1179111</idno>
                  <idno type="halauthorid" notation="string">615553-1179111</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8190-5853</idno>
                  <affiliation ref="#struct-1004777"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Sylvie</forename>
                    <surname>Bortoli</surname>
                  </persName>
                  <email type="md5">a9f7923018d12a2ed903d389f6272b2f</email>
                  <email type="domain">u-paris.fr</email>
                  <idno type="idhal" notation="numeric">1396000</idno>
                  <idno type="halauthorid" notation="string">1055517-1396000</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1008-1241</idno>
                  <affiliation ref="#struct-1226652"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22299</idno>
                <idno type="issn">0160-4120</idno>
                <title level="j">Environment International</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">199</biblScope>
                  <biblScope unit="pp">109503</biblScope>
                  <date type="datePub">2025</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.envint.2025.109503</idno>
              <idno type="pubmed">40359599</idno>
              <idno type="wos">001491632300001</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Cancer</term>
                <term xml:lang="en">Metabolic reprogramming</term>
                <term xml:lang="en">Mitochondria</term>
                <term xml:lang="en">Oncometabolite</term>
                <term xml:lang="en">Pesticides</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
              <classCode scheme="https://namespace.ccsd.cnrs.fr/hal/metadata/afssa_thematique" n="1">Affaires internationales</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Succinate dehydrogenase inhibitors (SDHi) are fungicides used worldwide to control the proliferation of fungi in crops. They act by blocking the activity of succinate dehydrogenase (SDH), a universal enzyme involved in mitochondrial functions and metabolism. While SDH-encoding genes are tumour suppressors, which loss-of-function mutations predispose to different types of rare tumors in humans, the consequences of chemical inactivation of SDH by SDHi remain largely unknown, particularly regarding their carcinogenic potential. Here, we investigated the metabolic and cellular impact of SDHi on human non-cancer and transformed colon cells. We show that SDHi inhibit SDH activity and increase the level of succinate, known to act as an oncometabolite in SDH-deficient cancers. SDHi exposure also induces a Warburg-like metabolic reprogramming typical of cancer cells, associated with transcriptomic and morphological changes promoting cell migration and invasion. These effects are enhanced in transformed colon cells carrying mutations in colorectal cancer (CRC) driver genes. These findings provide the first evidence that SDHi-mediated chemical inactivation of SDH mimics some metabolic and phenotypic features previously described in human tumors with SDH genetic deficiencies. Given that loss of SDH expression in CRC patients correlates with a poor prognosis, these patients could represent a population sensitive to SDHi exposure. Therefore, it would be wise to include them in biomonitoring programs. Finally, our work highlights the need to improve regulatory assessment procedures to take better account of SDHi mode of action, by developing relevant tests to cover the multiple key events linked to SDH inactivation and assess the resulting mitochondrial toxicity.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1226652" status="VALID">
          <idno type="IdRef">174964552</idno>
          <idno type="RNSR">200616420B</idno>
          <orgName>Health and Functional Exposomics</orgName>
          <orgName type="acronym">HealthFex | U1124</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Campus Saint-Germain-des-Prés - 45 rue des Saints-Pères, 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://healthfex-1124.u-paris-sciences.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1124" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 1124" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1612996" status="VALID">
          <idno type="IdRef">168079968</idno>
          <idno type="RNSR">201119649P</idno>
          <orgName>ToxAlim</orgName>
          <orgName type="acronym">ToxAlim</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>23 ch. Capelles 31076 TOULOUSE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www4.toulouse.inra.fr/toxalim</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR1331" active="#struct-577435" type="direct"/>
            <relation active="#struct-1574795" type="direct"/>
            <relation active="#struct-1602955" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1004693" status="VALID">
          <idno type="IdRef">166439185</idno>
          <idno type="ISNI">0000 0004 0495 1460</idno>
          <idno type="RNSR">201019165T</idno>
          <idno type="ROR">https://ror.org/03gvnh520</idno>
          <orgName>Paris-Centre de Recherche Cardiovasculaire</orgName>
          <orgName type="acronym">PARCC (UMR_S 970/ U970)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>56 rue Leblanc75015 PARISFRANCE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://parcc.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U970" active="#struct-300119" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation active="#struct-353414" type="indirect"/>
            <relation name="U970" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 970" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-1612938" status="VALID">
          <orgName>MetaboHUB-MetaToul</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Regroupement de 4 plateformes technologiques et d’expertises Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www6.toulouse.inrae.fr/metatoul/Presentation</ref>
          </desc>
          <listRelation>
            <relation active="#struct-414014" type="direct"/>
            <relation active="#struct-1612931" type="direct"/>
            <relation active="#struct-300421" type="indirect"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-303623" type="indirect"/>
            <relation name="UAR2039" active="#struct-441569" type="indirect"/>
            <relation active="#struct-577435" type="indirect"/>
            <relation active="#struct-1574795" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1004771" status="VALID">
          <idno type="ISNI">0000 0004 0368 8680</idno>
          <idno type="RNSR">199812928R</idno>
          <idno type="ROR">https://ror.org/028qedy27</idno>
          <orgName>Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques</orgName>
          <orgName type="acronym">LCBPT - UMR 8601</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>45 Rue des Saints-Pères 75270 PARIS CEDEX 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.biomedicale.univ-paris5.fr/umr8601/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR8601" active="#struct-441569" type="direct"/>
            <relation name="UMR 8601" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1612816" status="VALID">
          <idno type="IdRef">168095661</idno>
          <idno type="ISNI">0000 0004 7773 3907</idno>
          <idno type="RNSR">201119444S</idno>
          <idno type="ROR">https://ror.org/003412r28</idno>
          <idno type="Wikidata">Q30264420</idno>
          <orgName>Centre de Recherches en Cancérologie de Toulouse</orgName>
          <orgName type="acronym">CRCT</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Centre de Recherches en Cancérologie de Toulouse2 Avenue Hubert Curien31037 Toulouse Cedex 1FRANCE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.crct-inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1037" active="#struct-303623" type="direct"/>
            <relation name="UMR5071" active="#struct-441569" type="direct"/>
            <relation active="#struct-1574795" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-441367" status="VALID">
          <orgName>Centre de Microscopie de Rennes</orgName>
          <orgName type="acronym">MRic</orgName>
          <desc>
            <address>
              <addrLine>Biosit - Université de Rennes 1 - Campus de Villejean  -  Bât. 8 - 2 avenue du Professeur Léon Bernard - 35043 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-544521" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Biosit : biologie, santé, innovation technologique</orgName>
          <orgName type="acronym">SFR UMS CNRS 3480 - INSERM 018</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Campus de Villejean - Santé - Bâtiment 82 rue du Professeur Léon Bernard35043 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation name="US_S 018" active="#struct-303623" type="direct"/>
            <relation name="UAR3480 / UMS3480" active="#struct-441569" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-182194" status="VALID">
          <idno type="IdRef">177984775</idno>
          <idno type="RNSR">201722263E</idno>
          <idno type="ROR">https://ror.org/01p178v10</idno>
          <idno type="Wikidata">Q30261433</idno>
          <orgName>Institut de recherche en santé, environnement et travail</orgName>
          <orgName type="acronym">Irset</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>263 avenue Général Leclerc 35042 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.irset.org</ref>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-301986" type="direct"/>
            <relation name="U1085" active="#struct-303623" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-545073" status="VALID">
          <idno type="ISNI">0000 0000 9482 7121</idno>
          <idno type="ROR">https://ror.org/05byvp690</idno>
          <orgName>University of Texas Southwestern Medical Center</orgName>
          <desc>
            <address>
              <addrLine>5323 Harry Hines Blvd., Dallas, Texas, TX 75390</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.utsouthwestern.edu/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1004777" status="VALID">
          <idno type="IdRef">158039203</idno>
          <idno type="ISNI">0000 0004 0620 5824 </idno>
          <idno type="RNSR">200716512X</idno>
          <orgName>Centre de Recherche des Cordeliers</orgName>
          <orgName type="acronym">CRC (UMR_S_1138 / U1138)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>15 rue de l'Ecole de Médecine - Bâtiment B - 75270 Paris Cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crc.jussieu.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-110691" type="direct"/>
            <relation active="#struct-564132" type="indirect"/>
            <relation name="U1138" active="#struct-303623" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR_S_1138" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-300421" status="VALID">
          <idno type="ROR">https://ror.org/03m3gzv89</idno>
          <orgName>École nationale vétérinaire de Toulouse</orgName>
          <orgName type="acronym">ENVT</orgName>
          <desc>
            <address>
              <addrLine>23 chemin des Capelles - 31076 Toulouse Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://envt.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1574795" status="VALID">
          <orgName>Université de Toulouse</orgName>
          <orgName type="acronym">EPE UT</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 toute de Narbonne, 31062 Toulouse cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1602955" status="VALID">
          <orgName>Ecole d'Ingénieurs de Purpan</orgName>
          <orgName type="acronym">EI Purpan</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>75, voie du TOEC - BP 5761131076 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.purpan.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300119" status="VALID">
          <idno type="IdRef">052497380</idno>
          <idno type="ROR">https://ror.org/016vx5156</idno>
          <orgName>Hôpital Européen Georges Pompidou [APHP]</orgName>
          <orgName type="acronym">HEGP</orgName>
          <desc>
            <address>
              <addrLine>20, rue Leblanc, 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopital-georgespompidou.aphp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-353414" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-353414" status="VALID">
          <orgName>Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest</orgName>
          <orgName type="acronym">HUPO</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopitaux-parisouest.aphp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-414014" status="VALID">
          <idno type="ROR">https://ror.org/039gscz82</idno>
          <idno type="Wikidata">Q107518509</idno>
          <orgName>MetaboHUB</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>135 Avenue de Rangueil,31400 Toulouse, FRANCE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.metabohub.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1612931" status="VALID">
          <idno type="RNSR">202424518A</idno>
          <orgName>Génopole Toulouse Midi-Pyrénées [Auzeville]</orgName>
          <orgName type="acronym">GENOTOUL</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Chemin de Borde-Rouge Auzeville</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-303623" type="direct"/>
            <relation name="UAR2039" active="#struct-441569" type="direct"/>
            <relation active="#struct-577435" type="direct"/>
            <relation active="#struct-1574795" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-453207" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes</orgName>
          <orgName type="acronym">Biosit : Biologie - Santé - Innovation Technologique</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rennes - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301986" status="VALID">
          <idno type="IdRef">161356915</idno>
          <idno type="ISNI">0000 0001 1943 5037</idno>
          <idno type="ROR">https://ror.org/01sc83v92</idno>
          <orgName>École des Hautes Études en Santé Publique</orgName>
          <orgName type="acronym">EHESP</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ehesp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-110691" status="VALID">
          <idno type="IdRef">026375478</idno>
          <idno type="ISNI">0000000121955365</idno>
          <idno type="ROR">https://ror.org/046b3cj80</idno>
          <orgName>École Pratique des Hautes Études</orgName>
          <orgName type="acronym">EPHE</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ephe.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="ansesProject" xml:id="projanses-ANSES-19-EST-186">
          <idno type="anses">ANSES-19-EST-186</idno>
          <orgName>EpiMetCanSOHO</orgName>
          <desc>Impact de l’utilisation des fongicides SDHi : évaluation épidémiologique,épigénétique et métabolique en lien avec le cancer / Impact of the use of SDHi : Epidemiological, epigenetic and metabolic evaluation in relation to cancer</desc>
          <date type="start">2019-11-22</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>