<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05097744</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T04:05:23+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Staphylococcus aureus Genomic Analysis and Outcomes in Patients with Bone and Joint Infections: A Systematic Review</title>
            <author role="aut">
              <persName>
                <forename type="first">Kevin</forename>
                <surname>Bouiller</surname>
              </persName>
              <email type="md5">b653912b33fe1da4f4e7b6efcf0b6b82</email>
              <email type="domain">chu-besancon.fr</email>
              <idno type="idhal" notation="string">kevin-bouiller</idno>
              <idno type="idhal" notation="numeric">785201</idno>
              <idno type="halauthorid" notation="string">2093579-785201</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2177-4318</idno>
              <affiliation ref="#struct-300165"/>
              <affiliation ref="#struct-57629"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>David</surname>
              </persName>
              <idno type="idhal" notation="numeric">1548439</idno>
              <idno type="halauthorid" notation="string">161261-1548439</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1926-7800</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Kevin</forename>
                <surname>Bouiller</surname>
              </persName>
              <email type="md5">b653912b33fe1da4f4e7b6efcf0b6b82</email>
              <email type="domain">chu-besancon.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-06-04 16:35:27</date>
              <date type="whenModified">2025-09-22 12:10:07</date>
              <date type="whenReleased">2025-06-04 16:35:27</date>
              <date type="whenProduced">2023-02-06</date>
              <ref type="externalLink" target="https://www.mdpi.com/1422-0067/24/4/3234/pdf?version=1676963493"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1087362">
                <persName>
                  <forename>Kevin</forename>
                  <surname>Bouiller</surname>
                </persName>
                <email type="md5">b653912b33fe1da4f4e7b6efcf0b6b82</email>
                <email type="domain">chu-besancon.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05097744</idno>
            <idno type="halUri">https://hal.science/hal-05097744</idno>
            <idno type="halBibtex">bouiller:hal-05097744</idno>
            <idno type="halRefHtml">&lt;i&gt;International Journal of Molecular Sciences&lt;/i&gt;, 2023, 24 (4), pp.3234. &lt;a target="_blank" href="https://dx.doi.org/10.3390/ijms24043234"&gt;&amp;#x27E8;10.3390/ijms24043234&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">International Journal of Molecular Sciences, 2023, 24 (4), pp.3234. &amp;#x27E8;10.3390/ijms24043234&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-FCOMTE">Université de Franche-Comté</idno>
            <idno type="stamp" n="CHRONO-ENVIRONNEMENT" corresp="UNIV-FCOMTE">Laboratoire Chrono Environnement (UMR 6249)</idno>
            <idno type="stamp" n="TEST4-HALCNRS">collection test</idno>
            <idno type="stamp" n="INEE-CNRS">Institut écologie et environnement du CNRS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Staphylococcus aureus Genomic Analysis and Outcomes in Patients with Bone and Joint Infections: A Systematic Review</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Kevin</forename>
                    <surname>Bouiller</surname>
                  </persName>
                  <email type="md5">b653912b33fe1da4f4e7b6efcf0b6b82</email>
                  <email type="domain">chu-besancon.fr</email>
                  <idno type="idhal" notation="string">kevin-bouiller</idno>
                  <idno type="idhal" notation="numeric">785201</idno>
                  <idno type="halauthorid" notation="string">2093579-785201</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2177-4318</idno>
                  <affiliation ref="#struct-300165"/>
                  <affiliation ref="#struct-57629"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>David</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1548439</idno>
                  <idno type="halauthorid" notation="string">161261-1548439</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1926-7800</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">877092</idno>
                <idno type="issn">1661-6596</idno>
                <idno type="eissn">1422-0067</idno>
                <title level="j">International Journal of Molecular Sciences</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">24</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">3234</biblScope>
                  <date type="datePub">2023-02-06</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/ijms24043234</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Many studies have been published assessing the association between the presence of S. aureus genes and outcomes in patients with bone and joint infections (BJI), but it is not known if they have had similar findings. A systematic literature review was performed. All available data on studies in Pubmed between January 2000 to October 2022 reporting the genetic characteristics of S. aureus and the outcomes of BJIs were analyzed. BJI included prosthetic joint infection (PJI), osteomyelitis (OM), diabetic foot infection (DFI), and septic arthritis. Because of the heterogeneity of studies and outcomes, no meta-analysis was performed. With the search strategy, 34 articles were included: 15 articles on children and 19 articles on adults. In children, most BJI studied were OM (n = 13) and septic arthritis (n = 9). Panton Valentine leucocidin (PVL) genes were associated with higher biological inflammatory markers at presentation (n = 4 studies), more febrile days (n = 3), and more complicated/severe infection (n = 4). Other genes were reported anecdotally associated with poor outcomes. In adults, six studies reported outcomes in patients with PJI, 2 with DFI, 3 with OM, and 3 with various BJI. Several genes were associated with a variety of poor outcomes in adults, but studies found contradictory results. Whereas PVL genes were associated with poor outcomes in children, no specific genes were reported similarly in adults. Additional studies with homogenous BJI and larger sample sizes are needed.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-300165" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Besançon</orgName>
          <orgName type="acronym">CHRU Besançon</orgName>
          <desc>
            <address>
              <addrLine>3, boulevard A. Fleming - 25030 Besançon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-besancon.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-57629" status="VALID">
          <idno type="IdRef">166212377</idno>
          <idno type="ISNI">0000000103609610</idno>
          <idno type="RNSR">200812285Y</idno>
          <idno type="ROR">https://ror.org/028cef883</idno>
          <orgName>Laboratoire Chrono-environnement (UMR 6249)</orgName>
          <orgName type="acronym">LCE</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>16, route de Gray - 25030 Besançon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://chrono-environnement.univ-fcomte.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR6249" active="#struct-441569" type="direct"/>
            <relation active="#struct-458810" type="direct"/>
            <relation active="#struct-426438" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-458810" status="VALID">
          <idno type="IdRef">026403188</idno>
          <idno type="ISNI">0000000121883779</idno>
          <idno type="ROR">https://ror.org/03pcc9z86</idno>
          <orgName>Université de Franche-Comté</orgName>
          <orgName type="acronym">UFC</orgName>
          <desc>
            <address>
              <addrLine>1 rue Goudimel25030 Besançon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-fcomte.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-426438" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-426438" status="VALID">
          <idno type="IdRef">200716271</idno>
          <idno type="ISNI">0000 0004 4910 6615</idno>
          <idno type="ROR">https://ror.org/02dn7x778</idno>
          <orgName>Université Bourgogne Franche-Comté [COMUE]</orgName>
          <orgName type="acronym">UBFC</orgName>
          <date type="start">2015-04-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>32, avenue de l’observatoire25000 BESANCON</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ubfc.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>