Age-adapted percentiles of measured glomerular filtration in healthy individuals: extrapolation to living kidney donors over 65 years
2 CHU Nîmes - Hôpital Universitaire Carémeau [Nîmes]
3 Hôpital Edouard Herriot [CHU - HCL]
4 University of Groningen [Groningen]
5 Oslo University Hospital [Oslo]
6 Karolinska University Hospital [Stockholm]
7 Métabolomique et maladies métaboliques
8 Charité - UniversitätsMedizin = Berlin University Medicine
9 Uppsala University Hospital
10 UZ Leuven - Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain
11 Hôpital Pellegrin
12 CHELTER - Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias
13 Service Néphrologie, Hémodialyses [CHU Clermont-Ferrand]
14 CHUGA - CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble
15 HEGP - Hôpital Européen Georges Pompidou [APHP]
16 UFR Médecine UPCité - UFR Médecine [Santé] - Université Paris Cité
17 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades
18 ITERT - Institut de Transplantation et de Recherche en Transplantation [CHU Nantes]
19 U1064 Inserm - CR2TI - Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology
20 Infinity - Institut Toulousain des Maladies Infectieuses et Inflammatoires
21 Département de Néphrologie et Transplantation d'organes [CHU Toulouse]
22 CHU-Liège - Centre Hospitalier Universitaire de Liège
23 UMCG - University Medical Center Groningen [Groningen]
24 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
25 VIB-KU Leuven | CFM - VIB-KU Leuven Center for Microbiology
- Fonction : Auteur
- PersonId : 761576
- IdHAL : cyril-garrouste
- ORCID : 0000-0001-5166-5617
- Fonction : Auteur
- PersonId : 1254869
- ORCID : 0000-0001-7897-0806
- Fonction : Auteur
- PersonId : 1359472
- ORCID : 0000-0003-0947-2226
- Fonction : Auteur
- PersonId : 1132275
- ORCID : 0000-0001-6651-6390
- IdRef : 115875298
Résumé
Objectives Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we calculated percentiles of measured GFR (mGFR) in donors <65 years old and extrapolated these to donors ≥65 years old. Methods mGFR percentiles were calculated from a development cohort of French/Belgian living kidney donors <65 years (n=1,983), using quantiles modeled as cubic splines (two linear parts joining at 40 years). Percentiles were extrapolated and validated in an internal cohort of donors ≥65 years (n=147, France) and external cohort of donors and healthy subjects ≥65 years (n=329, Germany, Sweden, Norway, France, The Netherlands) by calculating percentages within the extrapolated 5th–95th percentile (P5–P95). Results Individuals in the development cohort had a higher mGFR (99.9 ± 16.4 vs. 86.4 ± 14 and 82.7 ± 15.5 mL/min/1.73 m 2 ) compared to the individuals in the validation cohorts. In the internal validation cohort, none (0%) had mGFR below the extrapolated P5, 12 (8.2%) above P95 and 135 (91.8%) between P5–P95. In the external validation cohort, five subjects had mGFR below the extrapolated P5 (1.5%), 25 above P95 (7.6%) and 299 (90.9%) between P5–P95. Conclusions We demonstrate that extrapolation of mGFR from younger donors is possible and might aid with decision-making in elderly donors.