Unveiling Pathological Insights and Accelerating Antiviral Drug Discovery in Respiratory Viral Infections with Polarized Organoids
Résumé
Over the past decade, organoid models have not only emerged as an innovative research model but also as a valuable tool in precision medicine, particularly in the field of respiratory diseases. These three-dimensional in vitro models can replicate the complex architecture of human tissues, providing opportunities to predict drug response. This is especially critical in the context of respiratory viruses for which effective antiviral treatments are often lacking. Moreover, respiratory organoids generated from individual human primary cells could revolutionize our understanding of pulmonary diseases like asthma, chronic obstructive pulmonary disease (COPD), or cystic fibrosis (CF). This work aims to explore the role of respiratory organoids in precision medicine, focusing on their application in studying viral respiratory infection and their potential to personalize treatment approaches for patients.
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