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            <title xml:lang="en">Ecotoxicological effects and bioconcentration of a dissolved Organophosphate Ester's mixture in the marine flagellate Isochrysis galbana</title>
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                <title xml:lang="en">Ecotoxicological effects and bioconcentration of a dissolved Organophosphate Ester's mixture in the marine flagellate Isochrysis galbana</title>
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              <p>Organophosphate esters (OPEs) are emerging organic contaminants due to their widespread use, environmental persistence and bioaccumulation potential. They are released into the environment and may affect the physiology of various marine organisms. To evaluate the effects of OPEs on marine microalgae, the phytoplankton species Isochrysis galbana was exposed to a mixture of 11 OPEs, and their impacts on growth, reactive oxygen species (ROS) production, lipid content, and their bioconcentration in cells were assessed. Results showed that after 11 days of exposure, growth was significantly inhibited (p&amp;lt;0.05) at elevated OPE concentrations (5 and 10 µg L-1 of each OPE). For 10 µg L-1 of each OPE, cell densities decreased by 76% and growth rates were 23% below those measured in the control. A stimulation of ROS production was observed even at environmentally relevant OPE concentrations (0.5 µg L-1 for each OPE), and the increase reached up to 3.6 times the ROS production of the control (p &amp;lt; 0.05) after 8 days of exposure to the highest tested concentration (10 µg L-1 of each OPE). Moreover, a positive correlation (r2 = 0.85, p &amp;lt; 0.05) was observed between bioconcentration factor (BCF) and log Kow. Interestingly, 3 out of the 11 OPEs: ethylhexyldiphenyl phosphate -EHDP-, tris(2-ethylhexyl) phosphate -TEHP-, and tritolyl phosphate -TMPP-, exceeded the BCF threshold values of 2000 L kg-1, considered to be bioacumulative in aquatic species according to European Union legislation. Together our results suggest that 1) OPEs affect I. galbana cells, mainly at high concentrations but to a certain extend at environmentally relevant levels, and 2) This species can bioconcentrate OPEs and represents a potential pathway through which these contaminants enter marine food webs. This study provides the first assessment of OPE accumulation in a microalgae frequently used in aquaculture.</p>
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