<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05050023</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T01:01:51+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Effects of chronic hypergravity: from adaptive to deleterious responses in growing mouse skeleton</title>
            <author role="aut">
              <persName>
                <forename type="first">Vasily</forename>
                <surname>Gnyubkin</surname>
              </persName>
              <idno type="halauthorid">1144159-0</idno>
              <affiliation ref="#struct-139834"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Guignandon</surname>
              </persName>
              <email type="md5">bbff6e201d83f53f2bdae7a95ccf785e</email>
              <email type="domain">univ-st-etienne.fr</email>
              <idno type="idhal" notation="string">alain-guignandon</idno>
              <idno type="idhal" notation="numeric">1389646</idno>
              <idno type="halauthorid" notation="string">186869-1389646</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0745-5417</idno>
              <idno type="IDREF">https://www.idref.fr/151343381</idno>
              <idno type="VIAF">https://viaf.org/viaf/283296408</idno>
              <affiliation ref="#struct-55679"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Norbert</forename>
                <surname>Laroche</surname>
              </persName>
              <idno type="idhal" notation="numeric">1499981</idno>
              <idno type="halauthorid" notation="string">246410-1499981</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9324-966X</idno>
              <affiliation ref="#struct-139834"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Vanden-Bossche</surname>
              </persName>
              <idno type="halauthorid">723840-0</idno>
              <affiliation ref="#struct-139834"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Myriam</forename>
                <surname>Normand</surname>
              </persName>
              <idno type="halauthorid">387288-0</idno>
              <affiliation ref="#struct-521755"/>
              <affiliation ref="#struct-193738"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Hélène</forename>
                <surname>Lafage-Proust</surname>
              </persName>
              <email type="md5">71447090831ca434283531417b22a769</email>
              <email type="domain">univ-st-etienne.fr</email>
              <idno type="idhal" notation="string">marie-helene-lafage-proust</idno>
              <idno type="idhal" notation="numeric">1514127</idno>
              <idno type="halauthorid" notation="string">186873-1514127</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2091-3961</idno>
              <affiliation ref="#struct-453061"/>
              <affiliation ref="#struct-51335"/>
              <affiliation ref="#struct-300284"/>
              <affiliation ref="#struct-224911"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurence</forename>
                <surname>Vico</surname>
              </persName>
              <idno type="halauthorid">186872-0</idno>
              <affiliation ref="#struct-139834"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Marie-Hélène</forename>
                <surname>Lafage-proust</surname>
              </persName>
              <email type="md5">71447090831ca434283531417b22a769</email>
              <email type="domain">univ-st-etienne.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-04-28 18:00:55</date>
              <date type="whenModified">2026-04-28 09:18:03</date>
              <date type="whenReleased">2025-04-28 18:00:55</date>
              <date type="whenProduced">2015-10-15</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="548634">
                <persName>
                  <forename>Marie-Hélène</forename>
                  <surname>Lafage-proust</surname>
                </persName>
                <email type="md5">71447090831ca434283531417b22a769</email>
                <email type="domain">univ-st-etienne.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05050023</idno>
            <idno type="halUri">https://hal.science/hal-05050023</idno>
            <idno type="halBibtex">gnyubkin:hal-05050023</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Applied Physiology&lt;/i&gt;, 2015, 119 (8), pp.908-917. &lt;a target="_blank" href="https://dx.doi.org/10.1152/japplphysiol.00364.2015"&gt;&amp;#x27E8;10.1152/japplphysiol.00364.2015&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Applied Physiology, 2015, 119 (8), pp.908-917. &amp;#x27E8;10.1152/japplphysiol.00364.2015&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="ICJ" corresp="UNIV-LYON1">Institut Camille Jordan</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="INSA-LYON">Institut National des Sciences Appliquées de Lyon</idno>
            <idno type="stamp" n="EC-LYON">Ecole Centrale de Lyon</idno>
            <idno type="stamp" n="INSMI">CNRS-INSMI - INstitut des Sciences Mathématiques et de leurs Interactions</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INSTITUTS-TELECOM">composantes instituts telecom </idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Effects of chronic hypergravity: from adaptive to deleterious responses in growing mouse skeleton</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Vasily</forename>
                    <surname>Gnyubkin</surname>
                  </persName>
                  <idno type="halauthorid">1144159-0</idno>
                  <affiliation ref="#struct-139834"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Guignandon</surname>
                  </persName>
                  <email type="md5">bbff6e201d83f53f2bdae7a95ccf785e</email>
                  <email type="domain">univ-st-etienne.fr</email>
                  <idno type="idhal" notation="string">alain-guignandon</idno>
                  <idno type="idhal" notation="numeric">1389646</idno>
                  <idno type="halauthorid" notation="string">186869-1389646</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0745-5417</idno>
                  <idno type="IDREF">https://www.idref.fr/151343381</idno>
                  <idno type="VIAF">https://viaf.org/viaf/283296408</idno>
                  <affiliation ref="#struct-55679"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Norbert</forename>
                    <surname>Laroche</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1499981</idno>
                  <idno type="halauthorid" notation="string">246410-1499981</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9324-966X</idno>
                  <affiliation ref="#struct-139834"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Vanden-Bossche</surname>
                  </persName>
                  <idno type="halauthorid">723840-0</idno>
                  <affiliation ref="#struct-139834"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Myriam</forename>
                    <surname>Normand</surname>
                  </persName>
                  <idno type="halauthorid">387288-0</idno>
                  <affiliation ref="#struct-521755"/>
                  <affiliation ref="#struct-193738"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Hélène</forename>
                    <surname>Lafage-Proust</surname>
                  </persName>
                  <email type="md5">71447090831ca434283531417b22a769</email>
                  <email type="domain">univ-st-etienne.fr</email>
                  <idno type="idhal" notation="string">marie-helene-lafage-proust</idno>
                  <idno type="idhal" notation="numeric">1514127</idno>
                  <idno type="halauthorid" notation="string">186873-1514127</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2091-3961</idno>
                  <affiliation ref="#struct-453061"/>
                  <affiliation ref="#struct-51335"/>
                  <affiliation ref="#struct-300284"/>
                  <affiliation ref="#struct-224911"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurence</forename>
                    <surname>Vico</surname>
                  </persName>
                  <idno type="halauthorid">186872-0</idno>
                  <affiliation ref="#struct-139834"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">5854</idno>
                <idno type="issn">8750-7587</idno>
                <idno type="eissn">1522-1601</idno>
                <title level="j">Journal of Applied Physiology</title>
                <imprint>
                  <publisher>American Physiological Society</publisher>
                  <biblScope unit="volume">119</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">908-917</biblScope>
                  <date type="datePub">2015-10-15</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1152/japplphysiol.00364.2015</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>One of the most important but least studied environmental factors playing a major role in bone physiology is gravity. While the knowledge of deleterious effects of microgravity on the skeleton is expanding, little is known about hypergravity and its osteogenic potential. Centrifugation was used to assess effects of 21-day continuous 2- or 3- g acceleration on femur and L2-vertebra of 7-wk-old male C57BL/6 mice. Under 3 g, body mass growth slowed down, and deleterious skeletal effects were found ( P &lt; 0.05 compared with control): cortical thinning, osteoclasts surface increase (+41% in femur, +20% in vertebra), and bone formation rate decrease (−34% in femur, −38% in vertebra). A 2- g centrifugation did not reduce body mass and improved trabecular volume (+18% in femur, +13% in vertebra) and microarchitecture (+32% connectivity density in femur, +9% trabecular thickness in vertebra, P &lt; 0.05 compared with control). Centrifugation at 2 g also decreased osteoclast surfaces (−36% in femur, −16% in vertebra) and increased the extent of mineralized surfaces (+31% in femur, +48% in vertebra, P &lt; 0.05 compare to control). Quantitative immunohistochemistry revealed an increase of dentin matrix acidic phosphoprotein 1 (DMP1) and decrease of sclerostin (+60% and −35% respectively, P &lt; 0.001 compared with control) in the femur cortex of 2- g mice. In the distal femur metaphysis, the number and volume of blood vessels increased by 22 and 44%, respectively ( P &lt; 0.05 compared with control). In conclusion, the effects of continuous hypergravity were bone compartment-specific and depended on the gravity level, with a threshold between beneficial 2- g and deleterious 3- g effects.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-139834" status="VALID">
          <idno type="IdRef">187116849</idno>
          <idno type="RNSR">201119433E</idno>
          <orgName>Biologie Intégrative du Tissu Osseux</orgName>
          <orgName type="acronym">LBTO</orgName>
          <date type="start">2011-01-01</date>
          <date type="end">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine Jacques Lisfranc 15 rue Ambroise Paré 42023 CEDEX 2 ST ETIENNE</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1059" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-55679" status="OLD">
          <orgName>Contraintes mécaniques et tissu osseux</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U890" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-521755" status="VALID">
          <orgName>Probabilités, statistique, physique mathématique</orgName>
          <orgName type="acronym">PSPM</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://math.univ-lyon1.fr/spip.php?article12</ref>
          </desc>
          <listRelation>
            <relation active="#struct-193738" type="direct"/>
            <relation active="#struct-126765" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-219748" type="indirect"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-300284" type="indirect"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="UMR5208" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-193738" status="VALID">
          <idno type="IdRef">111872227</idno>
          <idno type="ISNI">0000000403832988</idno>
          <idno type="RNSR">200511878U</idno>
          <idno type="ROR">https://ror.org/01ekw7f87</idno>
          <orgName>Institut Camille Jordan</orgName>
          <orgName type="acronym">ICJ</orgName>
          <date type="start">2005-01-01</date>
          <desc>
            <address>
              <addrLine>Bât. Jean Braconnier 43 bd du 11 novembre 1918 69622 VILLEURBANNE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://math.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-126765" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-219748" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="UMR5208" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-453061" status="VALID">
          <idno type="IdRef">234812249</idno>
          <idno type="RNSR">201622149K</idno>
          <orgName>Santé Ingénierie Biologie Saint-Etienne</orgName>
          <orgName type="acronym">SAINBIOSE</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - campus Santé Innovations10 rue de la Marandinière 42270 Saint Priest-en-Jarez</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://sainbiose.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-22135" type="direct"/>
            <relation active="#struct-29212" type="indirect"/>
            <relation active="#struct-302102" type="indirect"/>
            <relation active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1059" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51335" status="VALID">
          <idno type="IdRef">250789094</idno>
          <idno type="ROR">https://ror.org/04pn6vp43</idno>
          <orgName>Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]</orgName>
          <orgName type="acronym">CHU ST-E</orgName>
          <date type="start">1972-10-30</date>
          <desc>
            <address>
              <addrLine>42055 Saint Etienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300284" status="VALID">
          <idno type="IdRef">028209966</idno>
          <idno type="ISNI">0000 0001 2158 1682</idno>
          <idno type="ROR">https://ror.org/04yznqr36</idno>
          <idno type="Wikidata">Q623154</idno>
          <orgName>Université Jean Monnet - Saint-Étienne</orgName>
          <orgName type="acronym">UJM</orgName>
          <date type="start">1969-03-27</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10, Rue Tréfilerie – CS 8230142023 Saint-Étienne Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-224911" status="VALID">
          <orgName>Service de Rhumatologie [CHU Saint-Etienne]</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire de Saint-Étienne - 42055 SAINT-ÉTIENNE Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-st-etienne.fr/Offre_De_Soins/Rhumatologie/Presentation</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51335" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation active="#struct-300284" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1327915" status="VALID">
          <idno type="IdRef">285395831</idno>
          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-126765" status="VALID">
          <idno type="ROR">https://ror.org/05s6rge65</idno>
          <orgName>École Centrale de Lyon</orgName>
          <orgName type="acronym">ECL</orgName>
          <desc>
            <address>
              <addrLine>36 avenue Guy de Collongue - 69134 Ecully cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ec-lyon.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-219748" status="VALID">
          <idno type="IdRef">052444724</idno>
          <idno type="ISNI">0000 0001 2292 0228</idno>
          <orgName>Institut National des Sciences Appliquées de Lyon</orgName>
          <orgName type="acronym">INSA Lyon</orgName>
          <date type="start">1957-03-18</date>
          <desc>
            <address>
              <addrLine>20 Avenue Albert Einstein, 69621 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-22135" status="VALID">
          <orgName>Centre Ingénierie et Santé</orgName>
          <orgName type="acronym">CIS-ENSMSE</orgName>
          <desc>
            <address>
              <addrLine>158, cours Fauriel F-42023 Saint-Étienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.emse.fr/spip/-CIS-.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-29212" type="direct"/>
            <relation active="#struct-302102" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-29212" status="VALID">
          <orgName>École des Mines de Saint-Étienne</orgName>
          <orgName type="acronym">Mines Saint-Étienne MSE</orgName>
          <desc>
            <address>
              <addrLine>158, Cours Fauriel - 42023 Saint Étienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.mines-stetienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-302102" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-302102" status="VALID">
          <idno type="IdRef">192427156</idno>
          <idno type="ISNI">000000012202567X</idno>
          <idno type="ROR">https://ror.org/025vp2923</idno>
          <idno type="Wikidata">Q27962533</idno>
          <orgName>Institut Mines-Télécom [Paris]</orgName>
          <orgName type="acronym">IMT</orgName>
          <date type="start">2012-03-01</date>
          <desc>
            <address>
              <addrLine>19 Place Marguerite Perey, 91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.imt.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>