<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05048495</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T05:36:59+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Curcumin prevents dexamethasone-induced activation of the pseudorabies virus in rat pheochromocytoma cells through the miR-155-5p-Aak1-Numb/Notch2 signalling axis</title>
            <author role="aut">
              <persName>
                <forename type="first">Naixiu</forename>
                <surname>Wang</surname>
              </persName>
              <idno type="halauthorid">3499324-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fan</forename>
                <surname>Yang</surname>
              </persName>
              <idno type="halauthorid">2522661-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Zhiyun</forename>
                <surname>Qiu</surname>
              </persName>
              <idno type="halauthorid">3499325-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lin</forename>
                <surname>Zhang</surname>
              </persName>
              <idno type="halauthorid">350377-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dingqiu</forename>
                <surname>Zou</surname>
              </persName>
              <idno type="halauthorid">3499326-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yanru</forename>
                <surname>Tang</surname>
              </persName>
              <idno type="halauthorid">3499327-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ruihan</forename>
                <surname>Zhang</surname>
              </persName>
              <idno type="halauthorid">2231012-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chenlu</forename>
                <surname>Sun</surname>
              </persName>
              <idno type="halauthorid">3499328-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pei</forename>
                <surname>Liu</surname>
              </persName>
              <idno type="halauthorid">339749-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kexin</forename>
                <surname>Qi</surname>
              </persName>
              <idno type="halauthorid">3499329-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jingyi</forename>
                <surname>Wang</surname>
              </persName>
              <idno type="halauthorid">1289396-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hua</forename>
                <surname>He</surname>
              </persName>
              <idno type="halauthorid">1601737-0</idno>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Ling</forename>
                <surname>Gan</surname>
              </persName>
              <email type="md5">00cef3b6a0ce6e121c07c837daa78ca7</email>
              <email type="domain">swu.edu.cn</email>
              <idno type="idhal" notation="numeric">1364510</idno>
              <idno type="halauthorid" notation="string">3088340-1364510</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8228-2782</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>BMC</forename>
                <surname>BMC</surname>
              </persName>
              <email type="md5">750df22138c3a8cb85044e5ee79ee867</email>
              <email type="domain">biomedcentral.com</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-04-28 05:11:15</date>
              <date type="whenModified">2025-04-29 03:25:35</date>
              <date type="whenReleased">2025-04-28 08:32:26</date>
              <date type="whenProduced">2025-12</date>
              <date type="whenEndEmbargoed">2025-04-28</date>
              <ref type="file" target="https://hal.science/hal-05048495v1/document">
                <date notBefore="2025-04-28"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-05048495v1/file/13567_2025_Article_1509.pdf" id="file-5048495-4370850">
                <date notBefore="2025-04-28"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="326461">
                <persName>
                  <forename>BMC</forename>
                  <surname>BMC</surname>
                </persName>
                <email type="md5">750df22138c3a8cb85044e5ee79ee867</email>
                <email type="domain">biomedcentral.com</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05048495</idno>
            <idno type="halUri">https://hal.science/hal-05048495</idno>
            <idno type="halBibtex">wang:hal-05048495</idno>
            <idno type="halRefHtml">&lt;i&gt;Veterinary Research&lt;/i&gt;, 2025, 56 (1), pp.86. &lt;a target="_blank" href="https://dx.doi.org/10.1186/s13567-025-01509-9"&gt;&amp;#x27E8;10.1186/s13567-025-01509-9&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Veterinary Research, 2025, 56 (1), pp.86. &amp;#x27E8;10.1186/s13567-025-01509-9&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-5048495-4370850"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="ARINRAE-VR" corresp="ARINRAE">Veterinary Research</idno>
            <idno type="stamp" n="ARINRAE">Archives ouvertes des revues d'INRAE</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Curcumin prevents dexamethasone-induced activation of the pseudorabies virus in rat pheochromocytoma cells through the miR-155-5p-Aak1-Numb/Notch2 signalling axis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Naixiu</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="halauthorid">3499324-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fan</forename>
                    <surname>Yang</surname>
                  </persName>
                  <idno type="halauthorid">2522661-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Zhiyun</forename>
                    <surname>Qiu</surname>
                  </persName>
                  <idno type="halauthorid">3499325-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lin</forename>
                    <surname>Zhang</surname>
                  </persName>
                  <idno type="halauthorid">350377-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dingqiu</forename>
                    <surname>Zou</surname>
                  </persName>
                  <idno type="halauthorid">3499326-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yanru</forename>
                    <surname>Tang</surname>
                  </persName>
                  <idno type="halauthorid">3499327-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ruihan</forename>
                    <surname>Zhang</surname>
                  </persName>
                  <idno type="halauthorid">2231012-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chenlu</forename>
                    <surname>Sun</surname>
                  </persName>
                  <idno type="halauthorid">3499328-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pei</forename>
                    <surname>Liu</surname>
                  </persName>
                  <idno type="halauthorid">339749-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kexin</forename>
                    <surname>Qi</surname>
                  </persName>
                  <idno type="halauthorid">3499329-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jingyi</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="halauthorid">1289396-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hua</forename>
                    <surname>He</surname>
                  </persName>
                  <idno type="halauthorid">1601737-0</idno>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Ling</forename>
                    <surname>Gan</surname>
                  </persName>
                  <email type="md5">00cef3b6a0ce6e121c07c837daa78ca7</email>
                  <email type="domain">swu.edu.cn</email>
                  <idno type="idhal" notation="numeric">1364510</idno>
                  <idno type="halauthorid" notation="string">3088340-1364510</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8228-2782</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">19840</idno>
                <idno type="issn">0928-4249</idno>
                <idno type="eissn">1297-9716</idno>
                <title level="j">Veterinary Research</title>
                <imprint>
                  <publisher>BioMed Central</publisher>
                  <biblScope unit="volume">56</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">86</biblScope>
                  <date type="datePub">2025-12</date>
                  <date type="dateEpub">2025</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1186/s13567-025-01509-9</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">curcumin</term>
                <term xml:lang="en">pseudorabies virus</term>
                <term xml:lang="en">miR-155-5p/Aak1</term>
                <term xml:lang="en">DEX</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>AbstractPseudorabies virus (PRV) causes neurological disorders and organ damage in diseased animals. After initial infection, PRV activity is gradually inhibited; however, stress stimulation increases the host’s glucocorticoid levels, which overcomes the inhibition of PRV activity. Curcumin (Cur) helps maintain the inhibitory state of the Epstein-Barr virus, although further research is needed to establish whether Cur can prevent PRV activation triggered by stress hormones. In this study, we used PC-12 cells to determine the effects of Cur on PRV activation. The cells were successfully infected with PRV at a multiplicity of infection of 1 for 24 h, resulting in the inhibition of PRV activity. Following incubation with 0.5 µM dexamethasone (DEX) for 4 h, the inhibition of PRV activity was blocked. Further mechanistic analyses using a dual-luciferase assay revealed that miR-155-5p directly targets and regulates Aak1 and its downstream signalling molecules, Numb and Notch2, in maintaining and disrupting PRV inhibition. Moreover, in vitro experiments using miR-155-5p mimics and inhibitors, combined with Aak1 overexpression and interference, confirmed that the miR-155-5p-Aak1-Numb/Notch2 axis prevented DEX-induced disruption of PRV inhibition by Cur. These findings provide a novel regulatory target for preventing stress-activated PRV and provide evidence for the potential use of Cur as a stress modulator in practical applications.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
  </text>
</TEI>