<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05037752</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T23:08:10+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System</title>
            <author role="aut">
              <persName>
                <forename type="first">Nicholas</forename>
                <surname>George</surname>
              </persName>
              <idno type="halauthorid">3485354-0</idno>
              <affiliation ref="#struct-342556"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arianna</forename>
                <surname>Gentile Polese</surname>
              </persName>
              <idno type="halauthorid">3325839-0</idno>
              <affiliation ref="#struct-342556"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laetitia</forename>
                <surname>Merle</surname>
              </persName>
              <email type="md5">bfc984a737d430e70890030f50e6bd46</email>
              <email type="domain">u-bourgogne.fr</email>
              <idno type="idhal" notation="string">laetitia-merle</idno>
              <idno type="idhal" notation="numeric">1383902</idno>
              <idno type="halauthorid" notation="string">1119195-1383902</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5496-9253</idno>
              <affiliation ref="#struct-342556"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Wendy</forename>
                <surname>Macklin</surname>
              </persName>
              <idno type="halauthorid">2449314-0</idno>
              <affiliation ref="#struct-342556"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Diego</forename>
                <surname>Restrepo</surname>
              </persName>
              <idno type="halauthorid">1837458-0</idno>
              <affiliation ref="#struct-342556"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laetitia</forename>
                <surname>Merle</surname>
              </persName>
              <email type="md5">bfc984a737d430e70890030f50e6bd46</email>
              <email type="domain">u-bourgogne.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-05-19 16:23:27</date>
              <date type="whenModified">2025-05-19 16:23:27</date>
              <date type="whenReleased">2025-05-19 16:23:27</date>
              <date type="whenProduced">2022</date>
              <fs>
                <f name="inra_etatDocument_local" notation="string" n="VE">
                  <string>inra_etatDocument_local_VE</string>
                </f>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1545364">
                <persName>
                  <forename>Laetitia</forename>
                  <surname>Merle</surname>
                </persName>
                <email type="md5">bfc984a737d430e70890030f50e6bd46</email>
                <email type="domain">u-bourgogne.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05037752</idno>
            <idno type="halUri">https://hal.science/hal-05037752</idno>
            <idno type="halBibtex">george:hal-05037752</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Neuroscience&lt;/i&gt;, 2022, 42 (8), pp.1491-1509. &lt;a target="_blank" href="https://dx.doi.org/10.1523/JNEUROSCI.0305-21.2021"&gt;&amp;#x27E8;10.1523/JNEUROSCI.0305-21.2021&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Neuroscience, 2022, 42 (8), pp.1491-1509. &amp;#x27E8;10.1523/JNEUROSCI.0305-21.2021&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt/>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicholas</forename>
                    <surname>George</surname>
                  </persName>
                  <idno type="halauthorid">3485354-0</idno>
                  <affiliation ref="#struct-342556"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arianna</forename>
                    <surname>Gentile Polese</surname>
                  </persName>
                  <idno type="halauthorid">3325839-0</idno>
                  <affiliation ref="#struct-342556"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laetitia</forename>
                    <surname>Merle</surname>
                  </persName>
                  <email type="md5">bfc984a737d430e70890030f50e6bd46</email>
                  <email type="domain">u-bourgogne.fr</email>
                  <idno type="idhal" notation="string">laetitia-merle</idno>
                  <idno type="idhal" notation="numeric">1383902</idno>
                  <idno type="halauthorid" notation="string">1119195-1383902</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5496-9253</idno>
                  <affiliation ref="#struct-342556"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Wendy</forename>
                    <surname>Macklin</surname>
                  </persName>
                  <idno type="halauthorid">2449314-0</idno>
                  <affiliation ref="#struct-342556"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Diego</forename>
                    <surname>Restrepo</surname>
                  </persName>
                  <idno type="halauthorid">1837458-0</idno>
                  <affiliation ref="#struct-342556"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">PERIMETRE AUTRE</idno>
                <idno type="halJournalId" status="VALID">6330</idno>
                <idno type="issn">0270-6474</idno>
                <idno type="eissn">1529-2401</idno>
                <title level="j">Journal of Neuroscience</title>
                <imprint>
                  <publisher>Society for Neuroscience</publisher>
                  <biblScope unit="volume">42</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">1491-1509</biblScope>
                  <date type="datePub">2022</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1523/JNEUROSCI.0305-21.2021</idno>
              <idno type="pubmed">35022219</idno>
              <idno type="wos">000761258000003</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">axon initial segment</term>
                <term xml:lang="en">lateral olfactory tract</term>
                <term xml:lang="en">mitral cell</term>
                <term xml:lang="en">myelin</term>
                <term xml:lang="en">node of Ranvier</term>
                <term xml:lang="en">olfactory bulb</term>
              </keywords>
              <classCode scheme="halDomain" n="scco.neur">Cognitive science/Neuroscience</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The axon initial segment (AIS), nodes of Ranvier, and the oligodendrocyte-derived myelin sheath have significant influence on the firing patterns of neurons and the faithful, coordinated transmission of action potentials (APs) to downstream brain regions. In the olfactory bulb (OB), olfactory discrimination tasks lead to adaptive changes in cell firing patterns, and the output signals must reliably travel large distances to other brain regions along highly myelinated tracts. Whether myelinated axons adapt to facilitate olfactory sensory processing is unknown. Here, we investigate the morphology and physiology of mitral cell (MC) axons in the olfactory system of adult male and female mice and show that unilateral sensory deprivation causes system-wide adaptations in axonal morphology and myelin thickness. MC spiking patterns and APs also adapted to sensory deprivation. Strikingly, myelination and MC physiology were altered on both the deprived and nondeprived sides, indicating system level adaptations to reduced sensory input. Our work demonstrates a previously unstudied mechanism of plasticity in the olfactory system. SIGNIFICANCE STATEMENT Successful transmission of information from the olfactory bulb (OB) to piriform cortex through the lateral olfactory tract (LOT) relies on synchronized arrival of action potentials (APs). The coincident arrival of APs is dependent on reliable generation of APs in the axon initial segment (AIS) and fast conduction mediated by axon myelination. Here, we studied changes in mitral cell (MC) firing and AIS structure as well as changes in myelination of the LOT on unilateral olfactory deprivation in the adult mouse. Strikingly, myelination and MC physiology were altered on both the deprived and nondeprived sides, indicating system level adaptations to reduced sensory input. Our work demonstrates a previously unstudied mechanism of plasticity in the olfactory system.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-342556" status="VALID">
          <orgName>University of Colorado [Colorado Springs]</orgName>
          <desc>
            <address>
              <country key="US"/>
            </address>
            <ref type="url">https://www.uccs.edu/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>