Article Dans Une Revue eLife Année : 2025

In vivo targeted and deterministic single-cell malignant transformation

Résumé

This important study employs an optogenetics approach aimed at activating oncogene (KRASG12V) expression in a single somatic cell, with a focus on following the progression of activated cell to examine tumourigenesis probabilities under altered tissue environments. Although the description of the methodologies applied is incomplete, the authors propose a mechanism whereby reactivation of re-programming factors correlates with the increased likelihood of a mutant cell undergoing malignant transformation. This work will be of interest to developmental and cancer biologists, especially in relation to the genetic tools described.

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hal-05031119 , version 1 (11-04-2025)

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Pierluigi Scerbo, Benjamin Tisserand, Marine Delagrange, Héloise Debare, David Bensimon, et al.. In vivo targeted and deterministic single-cell malignant transformation. eLife, 2025, 13, pp.97650. ⟨10.7554/elife.97650⟩. ⟨hal-05031119⟩
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