Article Dans Une Revue European Journal of Endocrinology Année : 2025

Descriptive analysis and outcomes of PitNETs treated surgically during pregnancy and postpartum

Philippe Caron
  • Fonction : Auteur
Yves Reznik
  • Fonction : Auteur
Anne Rod
  • Fonction : Auteur

Résumé

Objective Data on pituitary neuroendocrine tumours (PitNETs) surgically treated during pregnancy are limited, and no studies have compared these cases to those treated in non-pregnant women. This study aimed to describe the clinical, radiological, and histological profiles of patients treated surgically for PitNETs during pregnancy and evaluate long-term prognosis. Design This study was multicentric, observational, and retrospective. Methods We included 10 patients from 5 university hospitals who underwent surgical treatment for PitNETs during pregnancy or within 12 months postpartum, along with 30 matched non-pregnant controls treated surgically for PitNETs. Clinical and histological data, as well as progression-free survival without additional treatment, were compared between pregnant and non-pregnant patients. Results and conclusions Among the 10 PitNETs, 4 were corticotropic, 2 gonadotropic, 2 lactotropic, and 2 somatotropic. The primary surgical indication (tumour syndrome with or without failure of medical treatment) was similar between the two groups: 7/10 vs 19/30 (P = 1.00). There was no statistically significant difference in volume (P = .072) or radiological invasion markers (optic chiasm compression, P = .059, and cavernous sinus invasion, P = .274). However, PitNETs in pregnant women showed higher mitotic activity (P = .038) and were more frequently classified as grade 2b (Trouillas clinicopathological classification; P = .049). The need for second-line treatment was also more frequent (P = .005). PitNETs requiring surgical treatment during pregnancy are characterized by increased proliferative activity and progression after surgery. Despite this, the long-term prognosis remains favourable. These results need confirmation in a larger study.

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hal-05029199 , version 1 (07-07-2025)

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Cindy Odot, Mathilde Brière, Marie Laure Raffin-Sanson, Mirella Hage, Chiara Villa, et al.. Descriptive analysis and outcomes of PitNETs treated surgically during pregnancy and postpartum. European Journal of Endocrinology, 2025, 192 (2), pp.150-158. ⟨10.1093/ejendo/lvaf018⟩. ⟨hal-05029199⟩
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